Keep Current with the Latest in Cell Biology Research
Block title
The MLL3/GRHL2 Complex Regulates Malignant Transformation and Anti-Tumor Immunity in Squamous Cancer
[Journal of Experimental Medicine] Utilizing CRISPR-edited, cross-species organoid modeling, researchers demonstrated that loss of MLL3 contributes to early squamous neoplastic evolution.
Mapping of the T-cell Landscape of Biliary Tract Cancer Unravels Anatomic Subtype-Specific Heterogeneity
[Cancer Research] Scientists conducted single-cell RNA sequencing and T-cell receptor sequencing on CD3+ T cells from 36 samples from 16 patients with biliary tract cancer across all subtypes and analyzed 355 pathologic slides to examine the spatial distribution of T cells and tertiary lymphoid structures.
Dasatinib-Resistant Universal CAR-T Cells Proliferate in the Presence of Host Immune Cells and Exhibit Antitumor Activity
[Molecular Therapy] Researchers introduced a T316I mutation in the leukocyte-specific protein tyrosine kinase (LCK) locus in CAR-T cells using the cytosine base editor (CBE) system.
CD4 T Cell Depletion Increases Memory Differentiation of Endogenous and CAR T Cells and Enhances the Efficacy of Super2 and IL-33-Armored CAR T Cells...
[Journal For Immunotherapy of Cancer] Investigators describe the intrinsic ability of CAR T cells to differentiate into memory T cells, the effect of cytokine armoring, and neoadjuvant CD4 depletion therapy on CAR and tumor-specific endogenous memory T cells.
The CD64/CD28/CD3ζ Chimeric Receptor Reprograms T-Cell Metabolism and Promotes T-Cell Persistence and Immune Functions While Triggering Antibody-Independent and Antibody-Dependent Cytotoxicity
[Experimental Hematology & Oncology] The CD64/CD28/CD3ζ -SFG retroviral vector was used to produce viruses for T-cell transduction. T-cell expansion and differentiation were monitored via flow cytometry. Gene expression was assessed by RNA-seq.
Long-Term Outcomes of GD2-Directed CAR-T Cell Therapy in Patients with Neuroblastoma
[Nature Medicine] Investigators describe the longest reported survival after CAR T therapy for active malignancy, demonstrating that GD2 CAR-ATC/VST therapy could safely produce up to more than 18 years of complete remission in children with refractory/relapsed neuroblastoma.
Blood–Brain-Barrier-Crossing Lipid Nanoparticles for mRNA Delivery to the Central Nervous System
[Nature Materials] The authors designed and synthesized 72 blood–brain barrier (BBB)-crossing lipids fabricated by conjugating BBB-crossing modules and amino lipids, and used them to assemble BBB-crossing lipid nanoparticles for mRNA delivery.
Allogeneic Chimeric Antigen Receptors (CARs) as an “Off-the-Shelf” Therapy in Multiple Myeloma
[Immunotherapy] Scientists investigate the current landscape and future perspectives of allogeneic CAR research in multiple myeloma, exploring both pre-clinical research and active clinical trials.
Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes
[Journal of Molecular Neuroscience] The authors suggested that irradiation activated astrocytes with altered polarity, generating both cellular and mitochondrial reactive oxygen species.
Tropisetron Attenuates High-Glucose-Induced Vascular Endothelial Dysfunction via Inhibition of Calcineurin/NFAT Signaling
[European Journal of Pharmacology] Researchers investigated the effects of tropisetron, a calcineurin inhibitor, on high glucose-induced hypertrophy and apoptosis in HUVECs.
NPRL2 Gene Therapy Induces Effective Antitumor Immunity in KRAS/STK11 Mutant Anti-PD1 Resistant Metastatic Non-Small Cell Lung Cancer (NSCLC) in a Humanized Mouse Model
[eLife] Researchers investigated NPRL2 antitumor immune responses in aPD1R/KRAS/STK11mt NSCLC in humanized-mice. Humanized-mice were generated by transplanting fresh human cord blood-derived CD34 stem cells into sub-lethally irradiated NSG mice.
Long Non-Coding RNAs (lncRNAs) in Cancer Development: New Insight from STAT3 Signaling Pathway to Immune Evasion
[Clinical and Experimental Medicine] Scientists comprehensively reviewed the regulatory roles of different lncRNAs on STAT3 and the mutual effects of this pathway in various aspects of carcinogenesis, including proliferation, apoptosis, metastasis, drug resistance, and angiogenesis.