Keep Current with the Latest in Cell Biology Research

Therapeutic Potential of the Secreted Kazal-Type Serine Protease Inhibitor SPINK4 in Colitis

[Nature Communications] Using single-cell sequencing to detect critical events in mucus dysfunction, researchers discovered that the Kazal-type serine protease inhibitor SPINK4 was dynamically regulated in colitic intestine in parallel with disease activities.

EMBER Creates a Unified Space for Independent Breast Cancer Transcriptomic Datasets Enabling Precision Oncology

[NPJ Breast Cancer] The authors presented an embedding approach called EMBER that created a unified space of 11,000 breast cancer transcriptomes and predicted phenotypes of transcriptomic profiles on a single sample basis.

TRIM59 Deficiency Promotes M1 Macrophage Activation and Inhibits Colorectal Cancer through the STAT1 Signaling Pathway

[Scientific Reports] Researchers generated macrophage-specific tripartite motif 59 conditional knockout mice and utilized these mice to establish colitis-associated cancer and MC38 transplanted colorectal cancer (CRC) models for further investigation. The deficiency of TRIM59 in macrophages inhibited colorectal tumorigenesis in mice.

Fabrication of ECM Protein Coated Hollow Collagen Channels to Study Peripheral Nerve Regeneration

[Scientific Reports] Researchers developed a reproducible in vitro hollow channel collagen gel construct to investigate peripheral nerve regeneratio by exploring the influence of key ECM proteins on axonal growth and regeneration.

Metabolic Phenotyping of Patients with Advanced Chronic Liver Disease for Better Characterization of Cirrhosis Regression

[Journal of Hepatology] Investigators assessed clinical factors, perform genotyping of known variants, and comprehensive metabolic phenotyping to characterize the regression of fibrosis in patients with compensated advanced chronic liver disease.

Biological Impact and Therapeutic Implication of Tumor-Associated Macrophages in Hepatocellular Carcinoma

[Cell Death & Disease] Macrophages can provide cell–cell communication in HCC by secreting exosomes having various types of biomolecules that transfer among cells and change their activity.

FXR Activation Remodels Hepatic and Intestinal Transcriptional Landscapes in Metabolic Dysfunction-Associated Steatohepatitis

[Acta Pharmacologica Sinica] By employing integrated transcriptome profiling of diverse FXR agonists-treated mice, FXR liver-specific knockout mice, and open-source human datasets, scientists determined that hepatic FXR activation effectively ameliorated MASH by reversing the dysregulated metabolic and inflammatory networks implicated in MASH pathogenesis.

Protective Function of Sclerosing Cholangitis on IBD

[Gut] Colitis severity was analyzed in experimental mouse models of colitis and sclerosing cholangitis, and people with IBD and PSC-IBD. Foxp3+ Treg-cell infiltration was assessed by qPCR and flow cytometry.

Function of Mast Cell and Bile-Cholangiocarcinoma Interplay in Cholangiocarcinoma Microenvironment

[Gut] Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics. Biliary molecules able to induce mast cell degranulation were revealed by in vitro and in vivo experiments, including liquid chromatography-mass spectrometry (MS)/MS and bioluminescence resonance energy transfer assays.

Hepatic IL22RA1 Deficiency Promotes Hepatic Steatosis by Modulating Oxysterol in the Liver

Researchers showed hepatic IL22RA1 is vital in hepatic lipid regulation. IL22RA1 was downregulated in palmitic acid-treated mouse primary hepatocytes, as well as in the...

Alcohol Is Driving a Half-Dozen Types of Cancer in the US, Study Finds

[STAT News] Alcohol has long been classified as a cancer-causing substance, but a recent study gave a clearer sense of just how many cancer cases and deaths may be driven by drinking.

13% of Patients with Dementia May Instead Have Cognitive Decline from Cirrhosis

[VCU Health] About 13% of individuals diagnosed with dementia may suffer instead from reversible cognitive decline caused by advanced liver disease, according to researchers from the Virginia Commonwealth University’s School of Medicine and the Richmond VA Medical Center.

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