Keep Current with the Latest in Cell Biology Research

Circulating Cytokines Present in Multiple Myeloma Patients Inhibit the Osteoblastic Differentiation of Adipose Stem Cells

Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.
[Leukemia]
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Osteogenic and Angiogenic Profiles of the Palatal Process of the Maxilla and the Palatal Process of the Palatine Bone

The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponds to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
[Journal of Anatomy]
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Intravenous Injection of Mesenchymal Stem Cell Spheroids Improves the Pulmonary Delivery and Prolongs In Vivo Survival

Murine adipose-derived MSC line m17.ASC was cultured in agarose-based microwell plates to obtain size-controlled m17.ASC spheroids of an average diameter and cell number of approximately 170 μm and 1100 cells/spheroid, respectively.
[Biotechnology Journal]
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KU Researcher Wins $1.25 Million Award to Investigate the Vital Role of Sex Hormones in Tissue Repair

A researcher at the University of Kansas has earned a five-year, $1.25 million Maximizing Investigators’ Research Award from the National Institutes of Health to study how estrogen interacts with the body at the level of the cell microenvironment.
[Universityof Kansas (News-Medical.Net)]
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Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing

The authors summarize current knowledge on how stem cell-derived nanovesicles regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process.
[Stem Cells International]
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Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.
[Journal of Inflammation Research]
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Pharmacological Effects of Ex Vivo Mesenchymal Stem Cell Immunotherapy in Patients with Acute Kidney Injury and Underlying Systemic Inflammation

A Phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product to preserve cell activity in patients with severe acute kidney injury.
[Stem Cells Translational Medicine]
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Co-Delivery of Fibrin-Laminin Hydrogel with Mesenchymal Stem Cell Spheroids Supports Skeletal Muscle Regeneration Following Trauma

MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.
[Tissue Engineering and Regenerative Medicine]
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Assessment of the Structural and Functional Characteristics of Human Mesenchymal Stem Cells Associated with a Prolonged Exposure of Morphine

To determine how a prolonged treatment could impair their functional characteristics, scientists exposed human MSCs to increasing morphine concentrations respectively for nine and eighteen days, evaluating in particular the fibrogenic potential exerted by the long-term exposition.
[Scientific Reports]
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Isolation of Neural Stem and Oligodendrocyte Progenitor Cells from the Brain of Live Rats

Isolated cells retain key in vivo self-renewal properties and their cell-type profile reflects the cell composition of their source area, while the function of the niche is sustained even eight months post-milking.
[Stem Cell Reports]
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Neuronal Pericellular Baskets: Neurotransmitter Convergence and Regulation of Network Excitability

The authors review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. They highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei.
[Trends in Neurosciences]
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