[Oncogenesis] By using both mouse and human TNBC cell lines, investigators found that diltiazem decreased colony formation and cell migration in breast cancer cells.

[Nature Cell Biology] Researchers discovered that a C2H2 zinc finger protein, ZNF827, is strongly induced during various contexts of epithelial-to-mesenchymal transition (EMT), including in brain development and breast cancer metastasis.

[Molecular Therapy Oncolytics] In an ex vivoassay, the size of freshly isolated human breast cancer tissues, including ER-positive & negative as well as HER2-positive & negative, was reduced by YS49-treated mesenchymal stem cell (MSC) derived conditioned medium.

[Molecular Therapy] Mechanistically, radiation significantly increased Icam1 expression on TNBC cells via activating nuclear factor κB (NF-κB) signaling, thereby promoting chimeric antigen receptor T cell infiltration and killing.

[Current Opinion in Genetics & Development] The author discusses the plasticity and function of adipocytes to tissue repair and fibrosis in four tissues: skin, heart, skeletal muscle, and mammary gland.

[Business Wire] Propanc Biopharma, Inc. today announced that a Notice of Allowance has been received from the European Patent Office for claims involving compositions of proenzymes to treat cancer.

[Reuters] Sanofi has stopped further work on amcenestrant, a treatment once seen to have strong commercial potential in breast cancer, after a second trial failure.

[Laboratory Investigation] Scientists explored the role of Kelch-like 17 (KLHL17) in the development and progression of NSCLC.

[International Immunology] Scientists examined whether short-chain fatty acids had protective effects against ischemia-reperfusion-induced acute lung injury and explored possible protective mechanisms.

[Cell Reports] Researchers confirmed findings through bioinformatic, tissue, and in vitro analyses, identifying that loss of NFKB inhibitor zeta in alveolar epithelial cells dysregulated the TGFβ/IL-6 signaling axis, which may impair homeostatic responses to environmental stress.

[Clinical and Translational Oncology] The authors investigated the effect of cancer cell-derived exosomal LINC00313 on the M2 macrophage differentiation in NSCLC and clarified its underlying mechanism.

[Cell Death Discovery] Investigators analyzed putative anti-pyroptosis effects of puerarin as mediated by the PP2A-HDAC1-NLRP3 pathway in acute lung injury.