[Scientific Reports] Scientists characterized the effect of C-type lectin domain family 12 member A (CLEC12A) signaling on virus control and neuropathology in Theiler’s murine encephalomyelitis virus infection.

[Cell Death & Disease] The authors identified promoter of tumor immune resistance 1 (PTIR1), a primate-specific splice variant of DDX58 lacking exon 4 and encoding a truncated RIG-I isoform, as a negative regulator of innate immune signaling.

[Blood] Scientists explored the molecular mechanisms underlying chronic active Epstein-Barr virus (EBV) infection (CAEBV) by performing a comprehensive multiomics analysis, including genome, transcriptome, epigenome, and single-cell transcriptome and surface proteome analyses, of 65 patients with CAEBV.

[Nature Communications] The authors investigated the role of HIV-1-specific CD8⁺ T cells and NK cells recognizing superimposed Pol peptides in selection and control of HIV-1 mutant virus.

[Communications Biology] Molecular and cellular experiments demonstrated that CAPRIN1 regulates the m6A modification of RIG-I RNA through direct interaction with METTL3, further influencing downstream interferon-associated gene networks and modulating Mycobacterium tuberculosis infection.

[Nature Microbiology] Investigators presented preclinical evidence of a safe and effective respiratory-delivered vaccine platform for inducing T cell-mediated sterilizing immunity against a respiratory pathogen.

[Experimental & Molecular Medicine] The authors offer an overview of the current knowledge on autoreactive T cells and autoantibodies identified in primary systemic lupus erythematosusor autoimmune myocarditis conditions from both clinical and preclinical studies.

[Cell Death & Disease] Scientists review the KRAS mutation-associated immune microenvironment features and discuss how KRAS remodels the immune microenvironment by regulating immune-related molecules, inflammatory factors, and multiple metabolic pathways.

[Nature Reviews Microbiology] The authors describe the origins and evolution of SARS-CoV-2, and outline variant and subvariant-specific characteristics.

[Scientific Reports] Investigators utilized siRNAs for Piwil-2 knock-down in Merkel cell carcinoma cells. Downregulation of Piwil-2 caused a significant change of 202 different PIWI-interacting RNAs and 419 proteins.

[Cell Death & Differentiation] Scientists observed that the expression of the deubiquitinating enzyme USP13 was significantly downregulated in diabetic cardiomyopathy mouse heart tissues.

[Cell Death Discovery] The authors employed mechanical actuation as a proxy reproducing extracellular matrix remodelling in vitro to trigger YAP1 nuclear shuttling in contractile cardiomyocytes derived from hESCs and iPSCs.