Keep Current with the Latest in Cell Biology Research
Dynamic Regulatory Elements in Single-Cell Multimodal Data Implicate Key Immune Cell States Enriched for Autoimmune Disease Heritability
[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.
[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.
[Nature Reviews Drug Discovery] Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.
[Nature Communications] Researchers found that excitatory and inhibitory synapses in the male Mus musculus and Rhesus macaque cortex form at similar rates, at similar times after birth.
Meningeal Interleukin-17-Producing T Cells Mediate Cognitive Impairment in a Mouse Model of Salt-Sensitive Hypertension
[Nature Neuroscience] In a mouse model of hypertension (HTN), scientists found that the neurovascular and cognitive dysfunction depended on interleukin-17, a cytokine elevated in individuals with HTN.
Interaction Dynamics between Innate and Adaptive Immune Cells Responding to SARS-CoV-2 Vaccination in Non-Human Primates
[Nature Communications] Scientists sorted innate immune cells from a pre-vaccine time point, as well as innate immune cells and antigen-specific peripheral B and T cells two weeks after each of two vaccine doses and used single-cell sequencing to assess the transcriptomes and adaptive immune receptors of each cell.
[Nature Communications] A cohousing experiment between type 1 diabetes (T1D) compared to non-obese diabetic (NOD) models revealed lower T1D incidence in NOD mice cohoused with 116C-NOD, associated with gut microbiota changes, reduced intestinal permeability, shifts in T and B cell subsets, and a transition from Th1 to Th17 responses.
The Tumor-Derived Cytokine Chi3l1 Induces Neutrophil Extracellular Traps That Promote T Cell Exclusion in Triple-Negative Breast Cancer
[Immunity] To identify mediators of T cell stromal restriction, researchers profiled murine breast tumors lacking the transcription factor Stat3, which is commonly hyperactive in breast cancers and promotes an immunosuppressive tumor microenvironment.
[Journal of Experimental Medicine] Through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ T follicular helper (Tfh) cells generated under different conditions, scientists discovered, in addition to PD-1hi effector Tfh cells, a CD62L+PD1low subpopulation.
[Heliyon] The authors summarize the roles of mechanosensitive ion channels in immune cells.
Interleukin-9 Production by Type 2 Innate Lymphoid Cells Induces Paneth Cell Metaplasia and Small Intestinal Remodeling
[Nature Communications] Investigators described the development of Paneth cell metaplasia in a murine model of chronic myelogenous leukemia that was driven by an inducible bcr-abl oncogene.
Bile Acid Metabolomics Identifies Chenodeoxycholic Acid as a Therapeutic Agent for Pancreatic Necrosis
[Cell Reports Medicine] Investigators conducted targeted metabolomic analyses to detect bile acids changes in patients during the acute and the recovery phases of acute pancreatitis, as well as in healthy controls.