Keep Current with the Latest in Cell Biology Research

Bellerophon Announces FDA Acceptance of Change to Ongoing Phase III REBUILD Study of INOpulse® for Treatment of Fibrotic Interstitial Lung Disease

[Bellerophon Therapeutics, Inc.] Bellerophon Therapeutics, Inc. announced that the FDA has accepted the company’s proposal to reduce the study size for its ongoing registrational REBUILD Phase III trial of INOpulse® for the treatment of fibrotic interstitial lung disease.

Airway Basal Cells Show a Dedifferentiated KRT17high Phenotype and Promote Fibrosis in Idiopathic Pulmonary Fibrosis

[Nature Communications] Researchers determined transcriptional changes of idiopathic pulmonary fibrosis-airway basal cells and their potential profibrotic properties using a 3D culture system and novel mouse xenograft models.

Liposomal UHRF1 siRNA Shows Lung Fibrosis Treatment Potential by Regulating Fibroblast Activation

[JCI Insight] Investigators found that growth factor–β1-mediated upregulation of UHRF1 repressed Beclin1 via promoter methylation induction which resulted in fibroblast activation and lung fibrosis both in vitro and in vivo.

Lung Fibrosis Finds an Unsung Hero in Neuropeptide Y

[American Journal of Respiratory Cell and Molecular Biology] Scientists studied neuropeptide Y, a small peptide normally synthesized in the central and peripheral nervous system and implicated in inflammatory airway diseases including asthma and COPD.

miR-31/QKI-5 Axis Facilitates Cell Cycle Progression of Non-Small-Cell Lung Cancer Cells by Interacting and Regulating p21 and CDK4/6 Expressions

[Cancer Medicine] Investigators demonstrated that RNA-binding protein Quaking-5 suppressed NSCLC cell proliferation both in vitro and in vivo by inhibiting cell cycle progression by regulating cell cycle G1 phase-related proteins.

Inhibiting ALK-TOPK Signaling Pathway Promotes Cell Apoptosis of ALK-Positive NSCLC

[Cell Death & Disease] Researchers discovered that T-LAK cell-oriented protein kinase (TOPK) was highly expressed in anaplastic lymphoma kinase (ALK)-positive NSCLC. Phosphorylation of TOPK by ALK was found to inhibit enhanced apoptosis of ALK-positive NSCLC cells, providing novel treatment strategies.

DDX17 Modulates the Expression and Alternative Splicing of Genes Involved in Apoptosis and Proliferation in Lung Adenocarcinoma Cells

[Peerj Life & Environment] Scientists explored the functions of DDX17 as an oncogene by regulating both the expression and alternative splicing of proliferation- and apoptosis-associated genes in lung adenocarcinoma cells.

Circular RNA hsa_circ_0018189 Drives Non-Small Cell Lung Cancer Growth by Sequestering miR-656-3p and Enhancing xCT Expression

[Journal of Clinical Laboratory Analysis] While identifying the relationship and functions of CircRNAs in NSCLC, researchers discovered that Hsa_circ_0018189 drove NSCLC growth by interacting with miR-656-3p and upregulating xCT.

CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

[International Journal of Inflammation] The authors review the roles of CXC ligands and their cognate receptors in the pathogenesis of several lung diseases such as allergic rhinitis, COPD, lung fibrosis, lung cancer, pneumonia, and tuberculosis.

Tissue- and Cell-Type-Specific Molecular and Functional Signatures of 16p11.2 Reciprocal Genomic Disorder Across Mouse Brain and Human Neuronal Models

[American Journal of Human Genetics] Researchers performed transcriptome profiling of 350 libraries from six tissues in mouse models harboring copy-number variants (CNVs) of the syntenic 7qF3 region, as well as cellular, transcriptional, and single-cell analyses in 54 isogenic neural stem cell, induced neuron, and cerebral organoid models of CRISPR-engineered 16p11.2 CNVs.

The Alternative Splicing of Intersectin 1 Regulated by PTBP1 Promotes Human Glioma Progression

[Cell Death & Disease] Transcriptome analysis using a large glioma cohort indicated that the ratio of ITSN1-S/ITSN1-L was positively correlated with glioma grading and poor prognosis.

Establishment of a Humanized Animal Model of Systemic Sclerosis in Which T Helper-17 Cells From Patients With Systemic Sclerosis Infiltrate and Cause Fibrosis in...

[Experimental & Molecular Medicine] Researchers introduced a novel animal model for systemic sclerosis (SSc) using immunodeficient mice injected with peripheral blood mononuclear cells from SSc patients.

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