Keep Current with the Latest in Cell Biology Research

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

[Cancer Research] Molecular, genetic, or pharmacological inhibition of adipose triglyceride lipase impaired human and murine prostate cancer growth in vivo and in cell culture or organoids under conditions mimicking the tumor microenvironment.

Targeting Tumor and Bone Microenvironment: Novel Therapeutic Opportunities for Castration-Resistant Prostate Cancer Patients with Bone Metastasis

[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize the recent studies which mainly focused on the role of tumor microenvironment or bone microenvironment in the CRPC patients with bone metastasis, and discussed the underlying mechanisms.

Understanding the Pathogenesis of Engineered Stone-Associated Silicosis: The Effect of Particle Chemistry on the Lung Cell Response

[Respirology] Human alveolar epithelial cells and macrophages were exposed in vitro to dust and assessed for cytotoxicity and inflammation.

Oncogenic KRAS Effector USP13 Promotes Metastasis in Non-Small Cell Lung Cancer through Deubiquitinating β-Catenin

[Cell Reports] Elevated USP13 promoted KRAS-mutant NSCLC metastasis, which was associated with poor prognosis in NSCLC patients.

MiR-1246b, a Novel miRNA Molecule of Extracellular Vesicles in Bronchoalveolar Lavage Fluid, Promotes Nodule Growth through FGF14 in Patients with Lung Cancer

[Cell Death & Disease] The binding targets and underlying mechanisms of the differentially expressed miRNAs were verified by in vitro and in vivo experiments

Harnessing T Cell Exhaustion and Trogocytosis to Isolate Patient-Derived Tumor-Specific TCR

[Science Advances] Investigators typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens in 39 consecutive transplanted patients, for 1 year after transplant.

Pathobiology of Nodal Peripheral T-Cell Lymphomas: Current Understanding and Future Directions

[Haematologica] The authors summarize current knowledge of the pathology and biology of nodal-based peripheral T- and NK- cell lymphomasentities, with an emphasis on recent findings and underlying oncogenic mechanisms.

FDA Investigating Serious Risk of T-cell Malignancy Following BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T Cell Immunotherapies

[FDA] The FDA has received reports of T cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies.

Modular Chimeric Cytokine Receptors with Leucine Zippers Enhance the Antitumour Activity of CAR T Cells via JAK/STAT Signaling

[Nature Biomedical Engineering] Investigators showed that replacement of the extracellular domains of heterodimeric cytokine receptors in T cells with two leucine zipper motifs provided optimal Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling.

CAR+ T Cell Lymphoma Post Ciltacabtagene Autoleucel Therapy for Relapsed Refractory Multiple Myeloma

[blood] The authors presented the clinicogenomic characterization of a CARTITUDE-4 patient who developed a CAR+ T cell lymphoma post cilta-cel. Diagnostic and staging workup included biopsy analyses and FDG-PET scan.

Phase I Clinical Trial of Intracerebroventricular Transplantation of Allogeneic Neural Stem Cells in People with Progressive Multiple Sclerosis

[Cell Stem Cell] Scientists reported the analysis of one year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation Phase I study to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells for the treatment of secondary progressive multiple sclerosis.

EpCAM-Targeting CAR-T Cell Immunotherapy Is Safe and Efficacious for Epithelial Tumors

[Science Advances] Researchers demonstrated that EpCAM–CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice.

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