Investigators introduced a natural bed-receptor surface as Microparticle Vesicle-Galactins1 (MV-gal1) with the ability of glycan binding to screen every spiked virus.
Researchers suggested that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.
Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO™ for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.
Using stable isotope labeling and mass spectrometry, research determine the in vivo turnover rates of thousands of proteins—including those of the extracellular matrix—in a set of biologically important mouse tissues.
Using breast cancer as a model of solid tumor metastasis to the bone marrow, we applied large-scale quantitative 3D imaging to characterize temporal changes in the bone marrow microenvironment during disease progression.
Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
Investigators presented the development of a 2D MXene-based hydrogel system for highly efficient photo- and magnetic-responsive drug delivery oriented to deep chronic wounds repair.
A higher matrix stiffness equipped tumor cells with enhanced stemness and proliferative characteristics, which was dependent on the activation of integrin β1/FAK/ERK1/2/NF-κB signaling pathway.
The authors identified a lncRNA, HOMER3-AS1, which was over-expressed in hepatocellular carcinoma (HCC) and correlated with poor survival of HCC patients. HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis.
RNA sequencing of liver tissue showed that the expression of SCD1 increased significantly in chronic periodontitis rats compared to controls. KEGG enrichment analysis showed that the AMPK signalling pathway may have been involved in liver steatosis.
Investigators showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.
