Keep Current with the Latest in Cell Biology Research

Dynamic Regulatory Elements in Single-Cell Multimodal Data Implicate Key Immune Cell States Enriched for Autoimmune Disease Heritability

[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.

Cellular Development and Evolution of the Mammalian Cerebellum

[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.

Targeting Synapse Function and Loss for Treatment of Neurodegenerative Diseases

[Nature Reviews Drug Discovery] Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.

Isochronic Development of Cortical Synapses in Primates and Mice

[Nature Communications] Researchers found that excitatory and inhibitory synapses in the male Mus musculus and Rhesus macaque cortex form at similar rates, at similar times after birth.

Meningeal Interleukin-17-Producing T Cells Mediate Cognitive Impairment in a Mouse Model of Salt-Sensitive Hypertension

[Nature Neuroscience] In a mouse model of hypertension (HTN), scientists found that the neurovascular and cognitive dysfunction depended on interleukin-17, a cytokine elevated in individuals with HTN.

Interaction Dynamics between Innate and Adaptive Immune Cells Responding to SARS-CoV-2 Vaccination in Non-Human Primates

[Nature Communications] Scientists sorted innate immune cells from a pre-vaccine time point, as well as innate immune cells and antigen-specific peripheral B and T cells two weeks after each of two vaccine doses and used single-cell sequencing to assess the transcriptomes and adaptive immune receptors of each cell.

Mutual Modulation of Gut Microbiota and the Immune System in Type 1 Diabetes Models

[Nature Communications] A cohousing experiment between type 1 diabetes (T1D) compared to non-obese diabetic (NOD) models revealed lower T1D incidence in NOD mice cohoused with 116C-NOD, associated with gut microbiota changes, reduced intestinal permeability, shifts in T and B cell subsets, and a transition from Th1 to Th17 responses.

The Tumor-Derived Cytokine Chi3l1 Induces Neutrophil Extracellular Traps That Promote T Cell Exclusion in Triple-Negative Breast Cancer

[Immunity] To identify mediators of T cell stromal restriction, researchers profiled murine breast tumors lacking the transcription factor Stat3, which is commonly hyperactive in breast cancers and promotes an immunosuppressive tumor microenvironment.

A Novel Memory-Like Tfh Cell Subset Is Precursor to Effector Tfh Cells in Recall Immune Responses

[Journal of Experimental Medicine] Through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ T follicular helper (Tfh) cells generated under different conditions, scientists discovered, in addition to PD-1hi effector Tfh cells, a CD62L+PD1low subpopulation.

Roles of Mechanosensitive Ion Channels in Immune Cells

[Heliyon] The authors summarize the roles of mechanosensitive ion channels in immune cells.

Interleukin-9 Production by Type 2 Innate Lymphoid Cells Induces Paneth Cell Metaplasia and Small Intestinal Remodeling

[Nature Communications] Investigators described the development of Paneth cell metaplasia in a murine model of chronic myelogenous leukemia that was driven by an inducible bcr-abl oncogene.

Bile Acid Metabolomics Identifies Chenodeoxycholic Acid as a Therapeutic Agent for Pancreatic Necrosis

[Cell Reports Medicine] Investigators conducted targeted metabolomic analyses to detect bile acids changes in patients during the acute and the recovery phases of acute pancreatitis, as well as in healthy controls.

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