Keep Current with the Latest in Cell Biology Research

Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.
[Neurology-Neuroimmunology & Neuroinflammation]
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Myeloid Ikaros–SIRT1 Signaling Axis Regulates Hepatic Inflammation and Pyroptosis in Ischemia-Stressed Mouse and Human Liver

Investigators undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.
[Journal of Hepatology]
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PDS Biotech Provides Recruitment update for National Cancer Institute-Led Phase 2 Clinical Trial of PDS0101-Based Combination

PDS Biotechnology Corporation announced the reopening of recruitment in the National Cancer Institute-led Phase II clinical trial evaluating PDS0101 in combination with two investigational immune-modulating agents in advanced HPV cancers.
[PDS Biotechnology Corporation]
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Cytokine-Induced Memory-Like Natural Killer Cells for Cancer Immunotherapy

NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data supports the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections.
[Stem Cell Research & Therapy]
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Diversity of Human NK Cell Developmental Pathways Defined by Single-Cell Analyses

Investigators offer a brief review of new insights into human NK cell diversity specifically defined by next generation sequencing and single-cell transcriptomic studies.
[Current Opinion in Immunology]
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Single-Cell Transcriptomic Identified HIF1A as a Target for Attenuating Acute Rejection after Heart Transplantation

A Total of 20 immune cell subtypes were identified among 46,040 cells. The function of immune cells in acute rejection were illustrated simultaneously.
[Basic Research in Cardiology]
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APOBEC3, TRIM5α, and BST2 Polymorphisms in Healthy Individuals of Various Populations with Special References to Its Impact on HIV Transmission

A brief account of the polymorphism in the APOBEC3G, TRIM5α, and BST2 genes are explored among different populations along with the interaction of APOBEC3G with Vif protein.
[Microbial Pathogenesis]
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Nonmuscle Myosin Heavy Chain IIA Facilitates SARS-CoV-2 Infection in Human Pulmonary Cells

The authors identified nonmuscle myosin heavy chain IIA as an important host factor for SARS-CoV-2 infection of human pulmonary cells by using APEX2 proximity-labeling techniques.
[Proceedings of the National Academy of Sciences of the United States of America]
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Delayed Induction of Type I and III Interferons Mediates Nasal Epithelial Cell Permissiveness to SARS-CoV-2

Scientists applied single-cell RNA sequencing and proteomics to a primary cell model of human nasal epithelium differentiated at air-liquid interface.
[Nature Communications]
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Genetic Mapping Reveals Nfkbid as a Central Regulator of Humoral Immunity to Toxoplasma gondii

The authors reported that unlike susceptible C57BL/6J mice, A/J mice were highly resistant to secondary infection.
[PLoS Pathogens]
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Robust Immune Responses Are Observed after One Dose of BNT162b2 mRNA Vaccine Dose in SARS-CoV-2 Experienced Individuals

Scientists evaluated longitudinal immune responses to two-dose BNT162b2 mRNA vaccination in 15 adults who had experienced COVID-19, compared to 21 adults who did not have prior COVID-19.
[Science Translational Medicine]
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