Keep Current with the Latest in Cell Biology Research

Truqap Plus Faslodex Approved in the EU for Patients with Advanced ER-Positive Breast Cancer

[AstraZeneca] AstraZeneca’s Truqap (capivasertib) in combination with Faslodex (fulvestrant) has been approved in the European Union (EU) for the treatment of adult patients with ER-positive, HER2‑negative locally advanced or metastatic breast cancer with one or more PIK3CA, AKT1, or PTEN-alterations following recurrence or progression on or after an endocrine-based regimen.

Breast Cancer Exploits Neural Signaling Pathways for Bone-to-Meninges Metastasis

[Science] Scientists applied a combination of intravital and ex vivo three-dimensional confocal microscopy, micro–computed tomography, and histologic analyses to mouse models of bone-metastatic breast cancer and leptomeninges (LM) metastasis,. They demonstrated that breast cancer cells could traffic to the LM from the bone marrow through abluminal emissary vein migration.

RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis

[Cancer Research] Investigators employed a CRISPR/Cas9 screening strategy that revealed RUVBL1 and RUVBL2 as putative targets. Loss of RUVBL1/2 preferentially impaired the growth of YTHDF1-high colorectal cancer (CRC) cells, patient-derived primary CRC organoids, and subcutaneous xenografts.

Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer

[Cancer Research] The authors applied a mass spectrometry-based proteomic approach to characterize human serum extracellular vesicles (EV) derived from patients with breast cancer (BC). TALDO1 was found to be an EV biomarker of distant metastasis of BC. In vitro and in vivo analysis confirmed the role of TALDO1 in stimulating BC invasion and metastasis.

Neoadjuvant Pembrolizumab, Dabrafenib, and Trametinib in BRAFV600-Mutant Resectable Melanoma: The Randomized Phase II NeoTrio Trial

[Nature Medicine] In the non-comparative, randomized, phase II NeoTrio trial, scientists investigated whether targeted therapy could boost the proportion of patients achieving long-term recurrence-free survival with neoadjuvant immunotherapy in resectable stage III BRAFV600-mutant melanoma.

QL1209 (Pertuzumab Biosimilar) versus Reference Pertuzumab plus Trastuzumab and Docetaxel in Neoadjuvant Treatment for HER2-Positive, ER/PR-Negative, Early or Locally Advanced Breast Cancer: A Multicenter,...

[British Journal of Cancer] This randomized, parallel-controlled, double-blinded, phase III equivalence study evaluated the equivalence of a proposed pertuzumab biosimilar QL1209 to the pertuzumab (Perjeta®) each with trastuzumab and docetaxel in neoadjuvant treatment of early or locally advanced breast cancer patients with HER2-positive, ER/PR-negative.

Lipid Nanoparticle (LNP) Mediated mRNA Delivery in Cardiovascular Diseases: Advances in Genome Editing and CAR T Cell Therapy

[Journal of Controlled Release] Investigators conclude that the strategies to facilitate the extra-hepatic delivery and targeted organ tropism of mRNA-lipid nanoparticles (LNPs) hold great prospects to accelerate the development and translation of mRNA-LNPs in cardiovascular disease treatment.

The Effect of Mesenchymal Stem Cell Conditioned Medium Incorporated Within Chitosan Nanostructure in Clearance of Common Gastroenteritis Bacteria In Vitro and In Vivo

[Scientific Reports] The antimicrobial and antibiofilm activity of human mesenchymal stem cell-derived conditioned medium encapsulated in chitosan nanoparticles was studied in vitro and in vivo against common gastroenteritis bacteria.

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT

[Cancer Research] Using a kinome-wide CRISPR screen, the authors identified PRKDC as a critical determinant of doxorubicin sensitivity in osteosarcoma.

CircMALAT1 Promotes Cancer Stem-Like Properties and Chemoresistance via Regulating Musashi-2/C-myc Axis in Esophageal Squamous Cell Carcinoma

[MedComm] The authors reported that circMALAT1 was significantly upregulated in esophageal squamous cell carcinoma (ESCC) CSC-like cells and primary tumors from ESCC patients.

Targeted Silencing of SOCS1 by DNMT1 Promotes Stemness of Human Liver Cancer Stem-Like Cells

[Cancer Cell International] Researchers elucidated the stemness-maintaining mechanism of human liver cancer stem-like cells (HLCSLCs) and provided a novel idea for the clearance of HLCSLCs.

T Cells Use Focal Adhesions to Pull Themselves Through Confined Environments

[Journal of Cell Biology] The authors showed that activated primary Th1 T cells required both confinement and extracellular matrix proteins to migrate efficiently.

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