[Nature Genetics] To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.

[Nature] The authors generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in human, mouse, and the marsupial opossum.

[Nature Reviews Drug Discovery] Investigators discuss recent advances in understanding the molecular and cellular pathways that impair synapses in neurodegenerative diseases, including the effects of protein aggregation and neuroinflammation.

[Nature Communications] Researchers found that excitatory and inhibitory synapses in the male Mus musculus and Rhesus macaque cortex form at similar rates, at similar times after birth.

[Nature Neuroscience] In a mouse model of hypertension (HTN), scientists found that the neurovascular and cognitive dysfunction depended on interleukin-17, a cytokine elevated in individuals with HTN.

[Nature Communications] Scientists sorted innate immune cells from a pre-vaccine time point, as well as innate immune cells and antigen-specific peripheral B and T cells two weeks after each of two vaccine doses and used single-cell sequencing to assess the transcriptomes and adaptive immune receptors of each cell.

[Nature Communications] A cohousing experiment between type 1 diabetes (T1D) compared to non-obese diabetic (NOD) models revealed lower T1D incidence in NOD mice cohoused with 116C-NOD, associated with gut microbiota changes, reduced intestinal permeability, shifts in T and B cell subsets, and a transition from Th1 to Th17 responses.

[Immunity] To identify mediators of T cell stromal restriction, researchers profiled murine breast tumors lacking the transcription factor Stat3, which is commonly hyperactive in breast cancers and promotes an immunosuppressive tumor microenvironment.

[Journal of Experimental Medicine] Through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ T follicular helper (Tfh) cells generated under different conditions, scientists discovered, in addition to PD-1hi effector Tfh cells, a CD62L+PD1low subpopulation.

[Heliyon] The authors summarize the roles of mechanosensitive ion channels in immune cells.

[Nature Communications] Investigators described the development of Paneth cell metaplasia in a murine model of chronic myelogenous leukemia that was driven by an inducible bcr-abl oncogene.

[Cell Reports Medicine] Investigators conducted targeted metabolomic analyses to detect bile acids changes in patients during the acute and the recovery phases of acute pancreatitis, as well as in healthy controls.