Keep Current with the Latest in Cell Biology Research

Insights for Disease Modeling from Single-Cell Transcriptomics of iPSC-Derived Ngn2-Induced Neurons and Astrocytes across Differentiation Time and Co-Culture

[BMC Biology] Scientists examined the homogeneity and similarity of human-induced pluripotent stem cells (hiPSC) derived neuron (hiPSC-N) and hiPSC derived astrocyte A (hiPSC-A) to their in vivo counterparts, the impact of different lengths of time post Ngn2 induction on hiPSC-N (15 or 21 days), and the impact of hiPSC-N/hiPSC-A co-culture.

Rare Genetic Variation in Fibronectin 1 (FN1) Protects against APOEε4 in Alzheimer’s Disease

[Acta Neuropathologica] Researchers hypothesized that APOEε4 carriers without dementia might carry genetic variations that could protect them from developing APOEε4-mediated Alzheimer's Disease pathology.

Endothelial DR6 in Blood-Brain Barrier Malfunction in Alzheimer’s Disease

[Cell Death & Disease] Investigators found that brain endothelial death receptor 6 (DR6) levels were significantly reduced in a murine model of Alzheimer's disease at the onset of amyloid-β accumulation.

The Requirement of the Mitochondrial Protein NDUFS8 for Angiogenesis

[Cell Death & Disease] The authors investigated the potential involvement of NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) in angiogenesis. In HUVECs and other endothelial cell types, they employed viral shRNA to silence NDUFS8 or employed the CRISPR/Cas9 method to knock it out.

Survivors of Polymicrobial Sepsis Are Refractory to G-CSF-Induced Emergency Myelopoiesis and Hematopoietic Stem and Progenitor Cell Mobilization

[Stem Cell Reports] The authors treated recovered sham and cecal ligation and puncture mice with a mobilizing regimen of granulocyte colony-stimulating factor (G-CSF) at day 20 post-surgery.

McPh1, Mutated in Primary Microcephaly, Is Also Crucial for Erythropoiesis

[EMBO Reports] Scientists revealed that microcephalin (Mcph1)-knockout mice exhibited congenital macrocytic anemia due to impaired terminal erythroid differentiation during fetal development.

HWJMSC-EVs Promote Cartilage Regeneration and Repair via the ITGB1/TGF-β/Smad2/3 Axis Mediated by Microfractures

[Journal of Nanobiotechnology] Researchers verify whether MSC-derived extracellular vesicles (MSC-EVs) promoted cartilage damage repair mediated by microfractures and to explore the repair mechanisms.

HERC5 Downregulation in Non-Small Cell Lung Cancer Is Associated with Altered Energy Metabolism and Metastasis

[Journal of Experimental & Clinical Cancer Research] Investigators assessed cell proliferation, colony formation potential, anchorage-independent growth, migration, and wound healing in NSCLC cell line models with HERC5 overexpression or knockout.

An Orthotopic Prostate Cancer Model for New Treatment Development Using Syngeneic or Patient-Derived Tumors

[The Prostate] Scientists described a novel micro-surgical technique for orthotopically implanting intact tumors pieces from cell line derived or patient derived tumors in the mouse prostate gland and monitoring tumor growth using magnetic resonance imaging.

COL5A1 Promotes Triple-Negative Breast Cancer Progression by Activating Tumor Cell-Macrophage Crosstalk

[Oncogene] Scientists reported that upregulation of collagen type V alpha 1 (COL5A1) in TNBC tissues, particularly in chemoresistant samples, was closely linked to an unfavorable prognosis.

RUVBL1 Ubiquitination by DTL Promotes RUVBL1/2-β-Catenin-Mediated Transcriptional Regulation of NHEJ Pathway and Enhances Radiation Resistance in Breast Cancer

[Cell Death & Disease] Investigators revealed that RUVBL1 was excessively expressed in mouse models undergoing radiotherapy, which is considered a murine spontaneous breast-tumor model. RUVBL1 enhanced DNA damage repair and radioresistance in breast cancer cells both in vitro and in vivo.

USP12 Facilitates Gastric Cancer Progression via Stabilizing YAP

[Cell Death Discovery] The authors conducted a screening using a deubiquitinase small interfering RNA library, leading to the identification of USP12 as an important deubiquitinase in the context of Hippo/YAP axis and the progression of gastric cancer.

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