Keep Current with the Latest in Cell Biology Research
Epithelial Nlrp10 Inflammasome Mediates Protection against Intestinal Autoinflammation
[Nature Immunology] Scientists showed that mouse Nlrp10 was expressed in distal colonic intestinal epithelial cells and modulated by the intestinal microbiome.
Blocking Dectin-1 Prevents Colorectal Tumorigenesis by Suppressing Prostaglandin E2 Production in Myeloid-Derived Suppressor Cells and Enhancing IL-22 Binding Protein Expression
[Nature Communications] Investigators found that azoxymethane-dextran-sodium-sulfate-induced and ApcMin-induced intestinal tumorigenesis were suppressed in Clec7a−/− mice independently from commensal microbiota.
Tumor Suppressive Role of the Musculoaponeurotic Fibrosarcoma Gene in Colorectal Cancer
[iScience] Researchers investigated whether microRNAs miR-200c, miR-302s, and miR-369s inhibited colorectal tumorigenesis in CPC;Apc mice, which were prone to colon and rectal polyps.
MORC4 Plays a Tumor-Promoting Role in Colorectal Cancer via Regulating PCGF1/CDKN1A Axis In Vitro and In Vivo
[Cancer Gene Therapy] The authors investigated the role of MORC family CW-type zinc finger 4 (MORC4) in colorectal cancer malignant behaviors, with an emphasis on polycomb group ring finger 1 (PCGF1)/cyclin-dependent kinase inhibitor 1A (CDKN1A) axis.
NR3C2 Inhibits the Proliferation of Colorectal Cancer via Regulating Glucose Metabolism and Phosphorylating AMPK
[Journal of Cellular and Molecular Medicine] Scientists investigated the roles and mechanisms of NR3C2 in colorectal cancer (CRC). The expression of NR3C2 in CRC tumors and paired paracancerous tissues of 71 CRC patients and five CRC cell lines was detected by western blotting, immunohistochemistry, and real-time reverse-transcription PCR.
Long Non-Coding RNA CR46040 Is Essential for Injury-Stimulated Regeneration of Intestinal Stem Cells in Drosophila
[Genetics] Investigators identified a long non-coding RNA, CR46040, that was essential for the injury-induced intestinal stem cell (ISC) regeneration in Drosophila. Loss of CR46040 greatly impaired ISCs proliferation in response to tissue damage caused by dextran sulfate sodium treatment.
PHKG2 Regulates RSL3-Induced Ferroptosis in Helicobacter pylori Related Gastric Cancer
[Archives of Biochemistry and Biophysics] The authors demonstrated that Helicobacter pylori infection increased the sensitivity of gastric cancer cells to RAS-selective lethal3 (RSL3) -induced ferroptosis. The molecular subtypes mediated by ferroptosis-related genes were associated with tumor microenvironment cell infiltration and patient survival.
LncRNA HOXB-AS4 Promotes Proliferation and Migration of Colorectal Cancer via the miR-140-5p/hdac7 Axis
[Biotechnology and Genetic Engineering Reviews] Researchers found that HOXB-AS4 was markedly upregulated in tumor tissues compared to precancerous tissues. Loss-of-function assays in HT29 and SW480 cells confirmed that knockdown of HOXB-AS4 inhibited proliferation, migration, and promoted apoptosis.
Noncoding RNAs as Regulators of STAT3 Pathway in Gastrointestinal Cancers: Roles in Cancer Progression and Therapeutic Response
[Medicinal Research Reviews] The authors elaborate on the tumor-promoting role of STAT3 signaling in gastrointestinal (GI) tumors. Subsequently, they discuss the oncogenic as well as tumor suppressor functions and mechanism of action of noncoding RNAs that are known to modulate STAT3 signaling in GI cancers.
The Emerging Roles of the Cytoskeleton in Intestinal Epithelium Homeostasis
[Seminars in Cell & Developmental Biology] Scientists highlight the contribution of the cell cytoskeleton- actin, microtubules, and intermediate filaments- to intestinal epithelium homeostasis. With a focus on enterocytes, they discuss the role of these networks in the formation and maintenance of cell-cell and cell-matrix junctions.
Goldenring’s Gastrointestinal Research Contributions Lauded
[Vanderbilt University Medical Center] James Goldenring, MD, PhD, the Paul W. Sanger Professor of Experimental Surgery at Vanderbilt University Medical Center, will receive the American Gastroenterological Association's Distinguished Achievement Award in Basic Science for making significant contributions to understanding gastrointestinal disease.
A Stimulus-Contingent Positive Feedback Loop Enables IFN-β Dose-Dependent Activation of Pro-Inflammatory Genes
[Molecular Systems Biology] Investigators showed that a high dose of IFN-β activated an inflammatory gene expression program in contrast to IFN-λ3, a type III IFN, which elicits only the common antiviral gene program.