Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.
Investigators undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.
PDS Biotechnology Corporation announced the reopening of recruitment in the National Cancer Institute-led Phase II clinical trial evaluating PDS0101 in combination with two investigational immune-modulating agents in advanced HPV cancers.
NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data supports the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections.
Investigators offer a brief review of new insights into human NK cell diversity specifically defined by next generation sequencing and single-cell transcriptomic studies.
A Total of 20 immune cell subtypes were identified among 46,040 cells. The function of immune cells in acute rejection were illustrated simultaneously.
A brief account of the polymorphism in the APOBEC3G, TRIM5α, and BST2 genes are explored among different populations along with the interaction of APOBEC3G with Vif protein.
The authors identified nonmuscle myosin heavy chain IIA as an important host factor for SARS-CoV-2 infection of human pulmonary cells by using APEX2 proximity-labeling techniques.
[Proceedings of the National Academy of Sciences of the United States of America]
Scientists evaluated longitudinal immune responses to two-dose BNT162b2 mRNA vaccination in 15 adults who had experienced COVID-19, compared to 21 adults who did not have prior COVID-19.
