Keep Current with the Latest in Cell Biology Research

Control of Satellite Cell Function in Muscle Regeneration and Its Disruption in Aging

Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. The authors discuss the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration.
[Nature Reviews Molecular Cell Biology]
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Gene-Editing, Immunological and iPSCs Based Therapeutics for Muscular Dystrophy

The authors summarize gene-editing, immunological and induced pluripotent stem cell based therapeutics for muscular dystrophy treatment.
[European Journal of Pharmacology]
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FDA Grants Fast Track Designation to AOC 1001 for the Treatment of Myotonic Dystrophy Type 1

Avidity Biosciences, Inc. announced that the US FDA has granted Fast Track Designation to its lead program, AOC 1001, for the treatment of myotonic dystrophy type 1.
[Avidity Biosciences, Inc. (BioSpace, Inc.)]
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Muscle Repair after Physiological Damage Relies on Nuclear Migration for Cellular Reconstruction

Scientists found that localized injuries, as experienced through exercise, activated a myofiber self-repair mechanism that was independent of satellite cells in mice and humans.
[Science]
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Inhibition of ABCC1 Decreases cAMP Egress and Promotes Human Airway Smooth Muscle Cell Relaxation

Using human airway smooth muscle cells in culture as a model, the authors reported that activation of the cell surface β2-adrenoceptor, a Gs-coupled G protein-coupled receptor, evoked cAMP egress to the extracellular space.
[American Journal of Respiratory and Critical Care Medicine]
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Loss of the Wild-Type KRAS Allele Promotes Pancreatic Cancer Progression through Functional Activation of YAP1

Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.
[Oncogene]
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Inhibiting Microcephaly Genes as Alternative to Microtubule Targeting Agents to Treat Brain Tumors

The genes mutated in primary hereditary microcephaly are ubiquitously expressed in proliferating cells, but under normal conditions are selectively required during brain development, in neural progenitors.
[Cell Death & Disease]
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The Presynaptic Glycine Transporter GlyT2 Is Regulated by the Hedgehog Pathway In Vitro and In Vivo

The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.
[Communications Biology]
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Hippocampal Disruptions of Synaptic and Astrocyte Metabolism Are Primary Events of Early Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer’s Disease

Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease.
[Cell Death & Disease]
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Cofilin1 Oxidation Links Oxidative Distress to Mitochondrial Demise and Neuronal Cell Death

Investigators presented the role of the actin-regulating protein cofilin1 in regulating mitochondrial pathways in oxidative neuronal death.
[Cell Death & Disease]
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Lung Neuroendocrine Neoplasms: Recent Progress and Persistent Challenges

The author summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma, and large cell neuroendocrine carcinoma.
[Modern Pathology]
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