Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.
The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponds to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
Murine adipose-derived MSC line m17.ASC was cultured in agarose-based microwell plates to obtain size-controlled m17.ASC spheroids of an average diameter and cell number of approximately 170 μm and 1100 cells/spheroid, respectively.
A researcher at the University of Kansas has earned a five-year, $1.25 million Maximizing Investigators’ Research Award from the National Institutes of Health to study how estrogen interacts with the body at the level of the cell microenvironment.
The authors summarize current knowledge on how stem cell-derived nanovesicles regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process.
Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.
A Phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product to preserve cell activity in patients with severe acute kidney injury.
MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.
To determine how a prolonged treatment could impair their functional characteristics, scientists exposed human MSCs to increasing morphine concentrations respectively for nine and eighteen days, evaluating in particular the fibrogenic potential exerted by the long-term exposition.
Isolated cells retain key in vivo self-renewal properties and their cell-type profile reflects the cell composition of their source area, while the function of the niche is sustained even eight months post-milking.
The authors review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. They highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei.
