Keep Current with the Latest in Cell Biology Research

Smoc1 and Smoc2 Regulate Bone Formation as Downstream Molecules of Runx2

To address the roles played by Runx2-regulated genes in bone formation, investigators identified Runx2 targets by performing RNA-sequencing and found Smoc1 and Smoc2 upregulation by Runx2.
[Communications Biology]
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Dissecting the Relationship between Antimicrobial Peptides and Mesenchymal Stem Cells

The authors discuss the production of antimicrobial peptides by MSCs, revise the multiple functions of these peptides, including their influence over MSCs, and present an overview of clinical situations in which the antimicrobial properties of MSCs may be explored for therapy.
[Pharmacology & Therapeutics]
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Ambulero’s Gene Therapy Candidate AMB-301 Granted US Orphan Drug Designation for Treatment of Severe Vascular Disease

Ambulero, Inc. announced that the US FDA’s Office For Orphan Products Development granted the company’s request for orphan drug status for its gene therapy candidate, AMB-301, to treat Buerger’s Disease, also known as Thromboangiitis Obliterans.
[Ambulero, Inc.]
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A Neutralizing IL-11 Antibody Reduces Vessel Hyperplasia in a Mouse Carotid Artery Wire Injury Model

Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, researchers postulated a critical role of TRPM7 in trophectoderm cells.
[Cell Reports]
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Integrated Computational Analyses Reveal Novel Insights into the Stromal Microenvironment of SHH-Subtype Medulloblastoma

The authors elucidated the role of the stromal microenvironment in SHH-subgroup medulloblastoma and identified novel treatment possibilities for this challenging disease.
[Scientific Reports]
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Fibrinolytic Nanocages Dissolve Clots in the Tumor Microenvironment, Improving the Distribution and Therapeutic Efficacy of Anticancer Drugs

Investigators used thrombolytic nanocages with multivalent clot-targeting peptides and fibrin degradation enzymes, such as microplasmin, to dissolve fibrin in the tumor microenvironment and named them fibrinolytic nanocages.
[Experimental and Molecular Medicine]
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Platelet-Mediated Tumor Metastasis Mechanism and the Role of Cell Adhesion Molecules

Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.
[Critical Reviews in Oncology/Hematology]
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Angiogenic Effects of Cell Therapy within a Biomaterial Scaffold in a Rat Hind Limb Ischemia Model

Researchers evaluated the ability of mast cells and MSCs to induce angiogenesis in a rat model of ischemic hind limb injury on a background of a tissue engineered hydrogel scaffold.
[Scientific Reports]
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Upregulation of CPNE7 in Mesenchymal Stromal Cells Promotes Oral Squamous Cell Carcinoma Metastasis through the NF-κB Pathway

Scientists demonstrated that MSCs derived from oral squamous cell carcinoma (OSCC) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition.
[Cell Death Discovery]
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Multiple Channels with Interconnected Pores in a Bioceramic Scaffold Promote Bone Tissue Formation

The authors developed a cell- and growth factor-free approach to induce bone formation in a critical-size bone defect by using an interconnected porous beta-tricalcium phosphate scaffold with multiple channels.
[Scientific Reports]
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PARK7 Promotes Repair in Early Steroid-Induced Osteonecrosis of the Femoral Head by Enhancing Resistance to Stress-Induced Apoptosis in Bone Marrow Mesenchymal Stem Cells via Regulation of the Nrf2 Signaling Pathway

Researchers investigated the mechanism driving a PARK7-mediated resistance to apoptosis in bone marrow MSCs and indicated that PARK7 promoted the disintegration of nuclear factor–like 2 (Nrf2)/Kelch-like echinacoside–associated protein 1 complex.
[Cell Death & Disease]
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