[Advanced Science] Scientists observed that Gaudichaudione H enhanced the sensitivity of HCC cells to disulfidptosis, which was dependent on the activation of NRF2-SLC7A11 pathway.

[Advanced Healthcare Materials] Inspired by Masquelet's technique, here a novel approach was devised to create periosteum mimetics from decellularized ECM, engineered in vivo through foreign body reaction, for reconstruction of segmental bone defects.

[Advanced Healthcare Materials] The authors provide insight into the mechanism of cancer metastasis involving invasion, intravasation, systemic transport of circulating tumor cells, extravasation, metastatic colonization, and angiogenesis.

[Journal of Experimental & Clinical Cancer Research] Scientists investigated the effect of dysmetabolism on pancreatic ductal adenocarcinoma (PDAC) development in a pre-clinical PDAC model with a specific focus on the stromal compartment.

[Advances in Nutrition] The authors examine the mechanistic pathways through which dietary fatty acids and sugars contribute the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in metabolic dysfunction-associated steatotic liver disease progression.

[Advanced Healthcare Materials] Scientists introduced a modular hydrogel system featuring a small peptide sequence that was selectively cleaved by the coagulation factor FXa. In a cell culture environment, where active FXa was absent, the hydrogel remained stable, providing a conducive matrix for the growth of tissue structures or organoid.

[Gut] Emerging data indicate that steatosis can be present in children under six years of age. The intricate interplay of genetics may inform future therapeutics and prognostication, with the PNPLA3 gene showing the most evidence for association with the risk and severity of steatotic liver disease and steatohepatitis.

[JNCI-Journal of The National Cancer Institute] A paired matched RNA expression dataset of patients with non-small cell lung cancers and brain metastases (BMs) was analyzed to idenfiy BM specific suppressive tumor microenvironment features.

[Journal of Clinical Investigation] The authors developed a proof-of-principle gene replacement strategy for developmental and epileptic encephalopathy (DEE) 52. They tested an adeno-associated viral vector encoding β1 subunit cDNA in Scn1b null mice.

[Nature Communications] Scientists developed a platform for synthesizing a class of branched ionizable lipids that improved endosomal escape.

[Circulation Research] Investigators used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific Phd2−/− preeclamptic mice.

[Scientific Reports] Researchers compared the osteogenic effects of Icariin (ICA) and Icariside II (ICSII), along with their respective osteogenic mechanisms.