Keep Current with the Latest in Cell Biology Research

Defining Mesenchymal Stem/Stromal Cell-Induced Myeloid-Derived Suppressor Cells Using Single-Cell Transcriptomics

[Molecular Therapy] The authors revealed seven distinct immune cell types including myeloid-derived suppressor cells in the CD11bmidLy6Cmid cells, while CD11bhiLy6Chi cells included mostly monocytes/macrophages with a small cluster of neutrophils.

Anti-Tumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD-1 to Treat Collagen-Rich Solid Tumors

[Molecular Cancer Therapeutics] Investigators reported leukocyte-associated immunoglobulin-like receptor 1 was associated with tumor stroma and was highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer.

Lactobacillus reuteri Vesicles Regulate Mitochondrial Function of Macrophages to Promote Mucosal and Cutaneous Wound Healing

[Advanced Science] Researchers revealed, for the initial time, the significant enhancement of mucosal and cutaneous wound healing by membrane vesicles secreted by the human commensal Lactobacillus reuteri through modulation of the inflammatory environment in wound tissue.

The CD318/CD6 Axis Limits Type 1 Diabetes Islet Autoantigen-Specific Human T Cell Activation

[Journal Of Autoimmunity] Scientists reported CD318 expression in a subpopulation of CD318+ myeloid dendritic, whereas the other peripheral blood populations were CD318 negative.

HERV-W Upregulation Expression in Bipolar Disorder and Schizophrenia: Unraveling Potential Links to Systemic Immune/Inflammation Status

[Retrovirology] Investigators assessed the level of human endogenous retrovirus W (HERV-W)-env expression and the systemic inflammatory profile through the concentration of IL-2, IL-4, IL-6, IL-10, TNF-α and INF-γ cytokines in bipolar disorder and schizophrenia patients.

HLA Reduction of Human T Cells Facilitates Generation of Immunologically Multi-compatible Cellular Products

[Blood Advances] Researchers showed that human leukocyte antigen knockout (HLA KO) does not alter T-cell functionality in vitro and in vivo. While HLA KO abrogated allogeneic T-cell responses, it elicited NK-cell recognition. To circumvent this problem, they demonstrated that selective editing of individual HLA class I molecules in primary human T cells was possible.

Bone Marrow CD8+ Trm Cells Induced by IL-15 and CD16+ Monocytes Contribute to HSPC Destruction in Human Severe Aplastic Anemia

[Clinical Immunology] Scientists performed single-cell RNA sequencing of peripheral blood and bone marrows and bone marrow mononuclear cells from severe aplastic anemia patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibited high IFN-γ and FasL expression and have a higher ability to induce apoptosis in hematopoietic stem and progenitor cells in vitro through FasL expression.

Systemic Lupus Erythematosus

[Lancet] The authors discuss a diagnostic approach to symptoms in light of the latest classification criteria, which include a systematic evaluation of clinical manifestations and autoantibody profiles.

Sandoz Confirms European Commission Approval of Pyzchiva® (Ustekinumab), Further Strengthening Immunology Offering

[Sandoz] Sandoz announces that the European Commission has granted marketing authorization for Pyzchiva® (biosimilar ustekinumab), developed and registered by Samsung Bioepis.

PAFAH1B3 Is a KLF9 Target Gene that Promotes Proliferation and Metastasis in Pancreatic Cancer

[Scientific Reports] Researchers found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) was highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes.

The Clinical Significance and Oncogenic Function of LRRFIP1 in Pancreatic Cancer

[Discover Oncology] Investigators explored the roles and mechanisms of leucine rich repeat of flightless-1 interacting protein 1 (LRRFIP1) in pancreatic cancer. The influences of LRRFIP1 on the proliferation and migration of pancreatic cancer cells were assessed in vitro.

MIF/NR3C2 Axis Regulates Glucose Metabolism Reprogramming in Pancreatic Cancer Through MAPK-ERK and AP-1 Pathways Get Access Arrow

[Carcinogenesis] Scientists provided evidence that migration inhibitory factor (MIF) and nuclear receptor subfamily 3 group C member 2 (NR3C2) interactively regulated metabolic reprogramming, resulting in MIF-induced cancer growth and progression in PDAC.

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