Keep Current with the Latest in Cell Biology Research

The Systemic Anti-Microbiota IgG Repertoire Can Identify Gut Bacteria That Translocate across Gut Barrier Surfaces

[Science Translational Medicine] The authors presented a modified high-throughput, culture-independent approach to quantify systemic immunoglobulin G (IgG) against gut commensal bacteria in human serum samples without the need for paired stool samples.

LACC1 Bridges NOS2 and Polyamine Metabolism in Inflammatory Macrophages

[Nature] Scientists elucidated a shared biochemical function of laccase domain-containing 1 (LACC1) in mice and humans, converting L-citrulline to L-ornithine and isocyanic acid and serving as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism.

Transcription-Independent Regulation of STING Activation and Innate Immune Responses by IRF8 in Monocytes

[Nature Communications] Investigators showed that interferon regulatory factor 8 (IRF8) was essential for efficient activation of STING-mediated innate immune responses in monocytes.

Longitudinal Proteomics Study of Serum Changes after Allogeneic HSCT Reveals Potential Markers of Metabolic Complications Related to aGvHD

[Scientific Reports] The authors examined changes in serum proteome via high-performance two-dimensional gel electrophoresis during HSC transplantation (HSCT) to search for diagnostic biomarkers for post-HSCT complications.

A Lymphatic-Absorbed Multi-Targeted Kinase Inhibitor for Myelofibrosis Therapy

[Nature Communications] Researchers demonstrated selectivity and therapeutic efficacy of a potent orally bioavailable multi-functional kinase inhibitor through reduction of downstream kinase activation, amelioration of disease phenotypes, and improved survival in animal models of myelofibrosis.

Durable Protection against the SARS-CoV-2 Omicron Variant Is Induced by an Adjuvanted Subunit Vaccine

[Science Translational Medicine] The authors presented data from a study in nonhuman primates demonstrating durable protection against the Omicron BA.1 variant induced by a subunit SARS-CoV-2 vaccine comprising the receptor binding domain of the ancestral strain on the I53-50 nanoparticle adjuvanted with AS03, which was recently authorized for use in individuals 18 years or older.

The Spike of SARS-CoV-2 Promotes Metabolic Rewiring in Hepatocytes

[Communications Biology] Investigators demonstrated that hepatocytes were susceptible to infection in different models: primary hepatocytes derived from humanized angiotensin-converting enzyme-2 mice and primary human hepatocytes.

MARTX Toxin of Vibrio vulnificus Induces RBC Phosphatidylserine Exposure That Can Contribute to Thrombosis

[Nature Communications] V. vulnificus infection at the sub-hemolytic level induced shape change of human red blood cells (RBCs) accompanied by phosphatidylserine exposure, and microvesicle generation, leading to the procoagulant activation of RBCs and ultimately, acquisition of prothrombotic activity.

The Evolving Role of Tissue-Resident Memory T Cells in Infections and Cancer

[Science Advances] Investigators provide a concise review of the development and physiological role of CD8+ resident memory T cells, their involvement in diseases, and their potential therapeutic exploitation.

IGF-Binding Proteins Secreted by Cancer-Associated Fibroblasts Induce Context-Dependent Drug Sensitization of Lung Cancer Cells

[Science Signaling] Gene expression and secretome analyses of cancer-associated fibroblasts and normal lung–associated fibroblasts revealed differential abundance of insulin-like growth factors (IGFs) and IGF-binding proteins, which promoted or inhibited, respectively, signaling by the receptor IGF1R and the kinase FAK.

Histone Lysine Demethylase Inhibition Reprograms Prostate Cancer Metabolism and Mechanics

[Molecular Metabolism] We investigated LSD1/UTX inhibition, two KDMs, in prostate cancer (PCa) and castration-resistant (CRPC) using a multi-omics approach.

Substantial Somatic Genomic Variation and Selection for BCOR Mutations in Human Induced Pluripotent Stem Cells

[Nature Genetics] Researchers found ultraviolet light (UV)-related damage in ~72% of skin fibroblast-derived hiPSCs, occasionally resulting in substantial mutagenesis.

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