[Life Science Alliance] Tracking of clonal dynamics by clonal tracing revealed that aged crypts drift into monoclonality substantially faster than young ones.

[Surrozen, Inc.] Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis.

[Nature Communications] The authors identified dysregulated RNA splicing as a key driver of tumour cell dedifferentiation in colorectal cancer.

[Molecular Therapy-Nucleic Acids] Investigators explored a gene targeting approach to deplete ephrinB2 from colorectal cancer cells using an inducible lentiviral vector.

[Cancer Science] To clarify the role of Class IIa Histone deacetylases (HDACs) in the metastasis of colon adenocarcinoma, investigators used the Class IIa HDAC inhibitor TMP269 and found that it effectively inhibited the migration ability of colon adenocarcinoma cells.

[Cancer Science] Researchers found that high neurokinin 2 receptor (NK2R) gene expression was correlated with the poor survival of colorectal cancer patients, and IFN-α/β stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a JAK1/2-dependent manner.

[Cell Death Discovery] The role of Scm-like with four malignant brain tumor domains 1 (SFMBT1) in the migration, proliferation and invasion of colorectal cancer or resistance to 5-fluorouracil was determined using scratch assay, colony formation and Transwell assay.

[BMC Microbiology] Scientists analyzed the effect of the Outer membrane protein A (OmpA) protein on the expression of the four genes related to apoptosis in the HCT116 colon cancer cell line.

[Proteome Science] Researchers determined the effect of cell-penetrable nanobody on cell viability and proteomic profile in epidermal growth factor receptor (EGFR)-positive human colorectal cancer cell lines.

[Febs Open Bio] ADP-ribosylation factor-like protein 2 (ARL2) was expressed at relatively low levels in K-RAS active colon cancer cells, but its expression was induced in cancer stem cells.

[Biochimica et Biophysica Acta-Reviews On Cancer] The authors discuss the general strategies for proteomic profiling of several key post-translational modifications (PTMs), and summarize the recent applications of these methods to explore the potential roles of the PTMs in colorectal cancer.

[Scientific Reports] To better classify the kinetics of mucosal vaccination with recombinant Lactobacillus acidophilus, investigators utilized mice harboring knockouts of NOD2 expression specifically within CD11c+ cells.