Keep Current with the Latest in Cell Biology Research

SMAD4 Mutations Do Not Preclude Epithelial–Mesenchymal Transition in Colorectal Cancer

It was widely assumed that SMAD4-mutant (SMAD4mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). Researchers scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4mut colorectal cancer cell lines.
[Oncogene]
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Microbiota-Specific T Follicular Helper Cells Drive Tertiary Lymphoid Structures and Anti-tumor Immunity against Colorectal Cancer

The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.
[Immunity]
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Responses of Increasingly Complex Intestinal Epithelium In Vitro Models to Bacterial Toll-Like Receptor Agonists

Researchers studied IL-8 secretion, as a marker of pro-inflammatory response through the Toll-like receptor (TLR) pathway, in a Caco-2 monoculture, Caco-2/HT29-MTX di-culture, Caco-2/HT29-MTX/HMVEC-d tri-culture and in a HT29-p monoculture in response to exposure to various TLR agonists.
[Toxicology in Vitro]
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Effects of Valerate on Intestinal Barrier Function in Cultured Caco-2 Epithelial Cell Monolayers

Valerate, a short-chain fatty acids mainly converted from proteins or amino acids, was demonstrated to promote intestinal barrier function at its physiological concentrations of 0–4 mM in the Caco-2 cell monolayer model of intestinal barrier.
[Molecular Biology Reports]
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JNK-Mediated Ser27 Phosphorylation and Stabilization of SIRT1 Promote Growth and Progression of Colon Cancer through Deacetylation-Dependent Activation of Snail

Scientists found that both Sirtuin 1 (SIRT1) and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines.
[Molecular Oncology]
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An Overview and Bibliometric Analysis on the Colorectal Cancer Therapy by Magnetic Functionalized Nanoparticles for the Responsive and Targeted Drug Delivery

Researchers outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment.
[Journal of Nanobiotechnology]
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Interaction between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

Scientists summarize the changes brought about by the changes of commensal bacteria to the inflammation of the intestines and their mutual influence.
[Frontiers in Immunology]
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MicroRNA miR-145-5p Regulates Cell Proliferation and Cell Migration in Colon Cancer by Inhibiting Chemokine (C-X-C Motif) Ligand 1 and Integrin α2

Researchers investigated the regulatory function of microRNA miR-145-5p in colon cancer (CC) cells. Bioinformatics analysis was used to screen key genes in CC.
[Bioengineered]
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Medtronic Receives Health Canada Licence for GI Genius Intelligent Endoscopy Module with Artificial Intelligence System for Colonoscopy

Medtronic Canada ULC, announced that it has received a Health Canada licence for the GI Genius intelligent endoscopy module. GI Genius is a computer-aided detection system that uses artificial intelligence to highlight regions of the colon suspected to have visual characteristics consistent with different types of mucosal abnormalities.
[Medtronic Canada ULC (BioSpace, Inc.)]
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Oncogenic Dependency on STAT3 Serine Phosphorylation in KRAS Mutant Lung Cancer

Researchers demonstrate that lung adenocarcinoma was suppressed in oncogenic KrasG12D-driven mouse models engineered for pS727-STAT3 deficiency.
[Oncogene]
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Cdk5 Drives Formation of Heterogeneous Pancreatic Neuroendocrine Tumors

Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.
[Oncogenesis]
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