Keep Current with the Latest in Cell Biology Research

NALCN-Mediated Sodium Influx Confers Metastatic Prostate Cancer Cell Invasiveness

[EMBO Journal] Using a variety of in vitro and in vivo techniques, researchers showed that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion.

Minor Intron Splicing Is Critical for Survival of Lethal Prostate Cancer

[Molecular Cell] Investigators explored the role of minor intron-containing genes and minor spliceosome in cancer, taking prostate cancer as an exemplar.

Histone H2A Lys130 Acetylation Epigenetically Regulates Androgen Production in Prostate Cancer

[Nature Communications] The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.

3D Bioprinting of Multi-Cellular Tumor Microenvironment for Prostate Cancer Metastasis

[Biofabrication] Scientists developed a novel bioink for the three-dimensional bioprinting of a coculture model that could be used to investigate the effect of hyaluronic acid on prostate cancer (PCa) behaviors and the mechanism underlying PCa-fibroblasts interaction.

Apoptotic and Anti-Warburg Effect of Morusin via ROS Mediated Inhibition of FOXM1/C-myc Signaling in Prostate Cancer Cells

[Phytotherapy Research] To elucidate antitumor mechanism of Morusin, cytotoxicity assay, cell cycle analysis, Western blotting, TUNEL assay, RNA interference, immunofluorescense, immunoprecipitation, reactive oxygen species measurement, and inhibitor study were applied.

Bromocriptine Monotherapy Overcomes Prostate Cancer Chemoresistance in Preclinical Models

[Translational Oncology] Using a two-tier phenotypic screening platform, researchers identified bromocriptine mesylate as a potent and selective inhibitor of chemoresistant prostate cancer cells.

Triiodothyronine Positively Regulates Endoplasmic Reticulum-Associated Degradation (ERAD) and Promotes Androgenic Signaling in Androgen-Dependent Prostate Cancer Cells

[Cellular Signalling] Scientists investigated the molecular action of triiodothyronine (T3) on the ERAD mechanism and unfolded protein response signaling in prostate cancer cells and also extensively examined the effect of T3 on androgenic signaling.

Investigation of Enzalutamide, Docetaxel, and Cabazitaxel Resistance in the Castration Resistant Prostate Cancer Cell Line C4 Using Genome-Wide CRISPR/Cas9 Screening

[Scientific Reports] To identify genes that modulated treatment response to these drugs, the authors performed three genome-wide CRISPR/Cas9 knockout screens in the metastatic CRPC cell line C4.

Autocrine Proteinase-Activated Receptor (PAR) Signaling in PC3 Prostate Cancer Cells

[American Journal Of Physiology-Cell Physiology] Investigators examined the androgen independent human prostatic cancer cell line PC3 and find functional expression of proteinase-activated receptor 1 (PAR1) and PAR2 but not PAR4.

A Combined In Vitro and Molecular Dynamics Simulation Studies Unveil the Molecular Basis of the Anticancer Potential of Piperine Targeting AKT1 against Prostate Cancer

[Journal Of Biomolecular Structure & Dynamics] Researchers investigated the activity of the natural compound piperine on prostate cancer cell line, followed by exploring its mechanistic inhibition on the RAC-alpha serine/threonine-protein kinase (AKT1) protein.

Therapeutic Implications of Cancer Stem Cells in Prostate Cancer

[Cancer Biology & Medicine] The authors discuss the origin, hierarchy, and plasticity of prostate cancer stem cells (PCSCs) and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance.

World Leading Cancer Trials in Birmingham Get £10 Million Boost

[University of Birmingham] Adults and children with cancer will continue to benefit from world-class clinical trials led by the University of Birmingham thanks to a new £10 million grant from Cancer Research UK.

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