Keep Current with the Latest in Cell Biology Research

Angiogenic Effects of Cell Therapy within a Biomaterial Scaffold in a Rat Hind Limb Ischemia Model

Researchers evaluated the ability of mast cells and MSCs to induce angiogenesis in a rat model of ischemic hind limb injury on a background of a tissue engineered hydrogel scaffold.
[Scientific Reports]
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Upregulation of CPNE7 in Mesenchymal Stromal Cells Promotes Oral Squamous Cell Carcinoma Metastasis through the NF-κB Pathway

Scientists demonstrated that MSCs derived from oral squamous cell carcinoma (OSCC) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition.
[Cell Death Discovery]
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Multiple Channels with Interconnected Pores in a Bioceramic Scaffold Promote Bone Tissue Formation

The authors developed a cell- and growth factor-free approach to induce bone formation in a critical-size bone defect by using an interconnected porous beta-tricalcium phosphate scaffold with multiple channels.
[Scientific Reports]
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PARK7 Promotes Repair in Early Steroid-Induced Osteonecrosis of the Femoral Head by Enhancing Resistance to Stress-Induced Apoptosis in Bone Marrow Mesenchymal Stem Cells via Regulation of the Nrf2 Signaling Pathway

Researchers investigated the mechanism driving a PARK7-mediated resistance to apoptosis in bone marrow MSCs and indicated that PARK7 promoted the disintegration of nuclear factor–like 2 (Nrf2)/Kelch-like echinacoside–associated protein 1 complex.
[Cell Death & Disease]
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Safety and Efficacy of Human Juvenile Chondrocyte-Derived Cell Sheets for Osteochondral Defect Treatment

Investigators demonstrated preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte sheets produced from routine surgical discards using thermo-responsive cultureware.
[NPJ Regenerative Medicine]
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Human Mesenchymal Stem Cells Derived Exosomes Inhibit the Growth of Acute Myeloid Leukemia Cells via Regulating miR-23b-5p/TRIM14 Pathway

TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.
[Molecular Medicine]
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Biomimetic Mechanically Strong One-Dimensional Hydroxyapatite/Poly(d,l-lactide) Composite Inducing Formation of Anisotropic Collagen Matrix

Inspired by the composition and microstructure of natural bone, researchers developed a biphasic composite consisting of highly aligned strontium/copper-doped one-dimensional hydroxyapatite and poly(d,l-lactide).
[ACS Nano]
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Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

DNA supramolecular hydrogel was applied as delivering material for MSCs to treat a severe osteoarthritis model, which performed extraordinary protection in MSCs against shear force both in vitro and in vivo.
[Advanced Materials]
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Autophagy in Mesenchymal Progenitors Protects Mice against Bone Marrow Failure after Severe Intermittent Stress

Researchers identified Wnt5a in Osterix+ mesenchymal progenitor and stem cells as a critical factor for niche-dependent hematopoiesis.
[Blood]
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Mutations and Variants of ONECUT1 in Diabetes

Directed differentiation of human PSCs revealed that loss of One Cut Homeobox 1 (ONECUT1) impaired pancreatic progenitor formation and a subsequent endocrine program.
[Nature Medicine]
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Microtubules Tune Mechanosensitive Cell Responses

Researchers show that talin- and actomyosin-dependent mechanosensing of substrate rigidity controls microtubule acetylation by promoting the recruitment of α-tubulin acetyltransferase 1 to focal adhesions.
[Nature Materials]
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