Keep Current with the Latest in Cell Biology Research

Appendage-Resident Epithelial Cells Expedite Wound Healing Response in Adult Zebrafish

[Current Biology] Scientists reported an unexpected role of adult zebrafish appendages (fins) in accelerating the re-epithelialization process. Through whole-body monitoring of single-cell dynamics in live animals, they found that fin-resident epithelial cells (FECs) were highly mobile and migrated to cover wounds in nearby body regions.

Determinants of Resistance and Response to Melanoma Therapy

[Nature Cancer] The authors discuss the determinants of melanoma tumor heterogeneity, mechanisms of therapy resistance and effective therapy regimens that hold curative promise.

Inhibition of PERK Mediated UPR Acts as a Switch for Reversal of Residual Senescence and as Senolytic Therapy in Glioblastoma

[Neuro-Oncology] Researchers delineated therapy induced senescence reversal mechanisms for potential therapeutic intervention to prevent glioblastoma recurrence.

N6-Methyladenosine Modified circPAK2 Promotes Lymph Node Metastasis via Targeting IGF2BPs/VEGFA Signaling in Gastric Cancer

[Oncogene] Researchers identified a novel N6-methyladenosine modified circRNA, circPAK2, which was significantly upregulated in gastric cancer tissues and metastatic lymph node tissues. CircPAK2 enhanced the migration, invasion, lymphangiogenesis, angiogenesis, epithelial-mesenchymal transitionm, and metastasis of gastric cancer in vitro and in vivo.

Eli Lilly Spends $3.2 Billion on Morphic’s Oral Integrin Inhibitor for Inflammatory Bowel Disease

[Nature Reviews Drug Discovery] Eli Lilly will acquire Morphic Therapeutic and a portfolio of integrin inhibitors for US$3.2 billion. Morphic’s lead candidate MORF-057, a selective oral small-molecule inhibitor of α4β7 integrin, is in Phase II trials for the treatment of inflammatory bowel disease (IBD).

GDNF-Induced Phosphorylation of MUC21 Promotes Pancreatic Cancer Perineural Invasion and Metastasis by Activating RAC2 GTPase

[Oncogene] Researchers demonstrated that MUC21 promoted the metastasis and perineural invasion of PDAC cells by activating JNK and inducing epithelial-mesenchymal transition (EMT).

Replication Timing Alterations Are Associated with Mutation Acquisition during Breast and Lung Cancer Evolution

[Nature Communications] Investigators assessed the impact of altered replication timing on cancer evolution by analyzing replication-timing sequencing of cancer and normal cell lines and 952 whole-genome sequenced lung and breast tumours.

MAZ-Mediated Up-Regulation of BCKDK Reprograms Glucose Metabolism and Promotes Growth by Regulating Glucose-6-Phosphate Dehydrogenase Stability in Triple-Negative Breast Cancer

[Cell Death & Disease] Researchers analyzed The Cancer Genome Atlas dataset and immunohistochemically stained surgical specimens to investigate branched-chain α-keto acid dehydrogenase kinase (BCKDK) expression and its prognostic implications in TNBC. The effects of BCKDK on tumorigenesis were assessed using cell viability, colony formation, apoptosis, and cell cycle assays, and subsequently validated in vivo.

Necroptosis Enhances ‘Don’t Eat Me’ Signal and Induces Macrophage Extracellular Traps to Promote Pancreatic Cancer Liver Metastasis

[Cell Death & Disease] Using RNA sequencing and multiplex immunofluorescence, investigators reported elevated expression of mixed lineage kinase domain-like pseudo-kinase (MLKL) and enhanced necroptosis pathway in PDAC from early liver metastasis T-stage patients comparing with non-metastatic patients.

Building a Human Lung from Pluripotent Stem Cells to Model Respiratory Viral Infections

[Respiratory Research] The authors propose a guideline using iPSCs to create all the disease-relevant cell types. iPSCs can be differentiated into lung epithelium, innate immune cells, endothelial cells, and fibroblasts at a large scale, recapitulating in vivo functions and providing genetic tractability.

Mendoza, Weiss Receive $2.6 Million Grant to Study Biomechanics of Lung Tumors

[Huntsman Cancer Institute] Dr. Michelle Mendoza and Dr. Jeffrey Weissare the recipients of a $2.6 million grant from the National Institutes of Health to research how tension in lung tissue affects the growth and distribution of tumors.

Novel Combinations of Immunotherapies or DNA Damage Repair Inhibitors in Platinum-Refractory Extensive-Stage Small-Cell Lung Cancer: The Phase II Baltic Study

[Clinical Cancer Research] The Phase II, multiarm, signal-searching BALTIC study assessed novel treatment combinations for platinum-refractory/resistant extensive-stage small-cell lung cancer.

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