Keep Current with the Latest in Cell Biology Research

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2-SLC7A11 Signaling Pathway

[Advanced Science] Scientists observed that Gaudichaudione H enhanced the sensitivity of HCC cells to disulfidptosis, which was dependent on the activation of NRF2-SLC7A11 pathway.

Masquelet Inspired in Vivo Engineered Extracellular Matrix as Functional Periosteum for Bone Defect Repair and Reconstruction

[Advanced Healthcare Materials] Inspired by Masquelet's technique, here a novel approach was devised to create periosteum mimetics from decellularized ECM, engineered in vivo through foreign body reaction, for reconstruction of segmental bone defects.

Navigating Tumor Microenvironment Barriers with Nanotherapeutic Strategies for Targeting Metastasis

[Advanced Healthcare Materials] The authors provide insight into the mechanism of cancer metastasis involving invasion, intravasation, systemic transport of circulating tumor cells, extravasation, metastatic colonization, and angiogenesis.

The GLP-1R Agonist Semaglutide Reshapes Pancreatic Cancer Associated Fibroblasts Reducing Collagen Proline Hydroxylation and Favoring T Lymphocyte Infiltration

[Journal of Experimental & Clinical Cancer Research] Scientists investigated the effect of dysmetabolism on pancreatic ductal adenocarcinoma (PDAC) development in a pre-clinical PDAC model with a specific focus on the stromal compartment.

Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease – The Molecular Role of Fatty Acids Versus Sugars in Human Metabolism and Disease Progression

[Advances in Nutrition] The authors examine the mechanistic pathways through which dietary fatty acids and sugars contribute the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in metabolic dysfunction-associated steatotic liver disease progression.

FXa-Responsive Hydrogels to Craft Corneal Endothelial Lamellae

[Advanced Healthcare Materials] Scientists introduced a modular hydrogel system featuring a small peptide sequence that was selectively cleaved by the coagulation factor FXa. In a cell culture environment, where active FXa was absent, the hydrogel remained stable, providing a conducive matrix for the growth of tissue structures or organoid.

Metabolic Dysfunction-Associated Steatotic Liver Disease in Children

[Gut] Emerging data indicate that steatosis can be present in children under six years of age. The intricate interplay of genetics may inform future therapeutics and prognostication, with the PNPLA3 gene showing the most evidence for association with the risk and severity of steatotic liver disease and steatohepatitis.

Engineered Allogeneic Stem Cells Orchestrate T Lymphocyte Driven Immunotherapy in Immunosuppressive Leptomeningeal Brain Metastasis

[JNCI-Journal of The National Cancer Institute] A paired matched RNA expression dataset of patients with non-small cell lung cancers and brain metastases (BMs) was analyzed to idenfiy BM specific suppressive tumor microenvironment features.

Neonatal but not Juvenile Gene Therapy Reduces Seizures and Prolongs Lifespan in SCN1B-Dravet Syndrome Mice

[Journal of Clinical Investigation] The authors developed a proof-of-principle gene replacement strategy for developmental and epileptic encephalopathy (DEE) 52. They tested an adeno-associated viral vector encoding β1 subunit cDNA in Scn1b null mice.

Branched Endosomal Disruptor (BEND) Lipids Mediate Delivery of mRNA and CRISPR-Cas9 Ribonucleoprotein Complex for Hepatic Gene Editing and T Cell Engineering

[Nature Communications] Scientists developed a platform for synthesizing a class of branched ionizable lipids that improved endosomal escape.

Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia

[Circulation Research] Investigators used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific Phd2−/− preeclamptic mice.

Investigation of the Osteogenic Effects of ICA and ICSII on Rat Bone Marrow Mesenchymal Stem Cells

[Scientific Reports] Researchers compared the osteogenic effects of Icariin (ICA) and Icariside II (ICSII), along with their respective osteogenic mechanisms.

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