[Nature Cell Biology] Using intracranial injections in mice and assembloids between small-cell lung cancer (SCLC) aggregates and human cortical organoids in culture, the authors found that SCLC cells recruited reactive astrocytes to the tumor microenvironment.

[Neuro-Oncology] Infant medulloblastoma-bearing Math1-cre::Ptch1 Fl/Fl mice were treated with intraventricular Vismodegib in order to evaluate efficacy on tumor growth and systemic side effects.

[Experimental & Molecular Medicine] Investigators developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult mouse NSCs.

[British Journal of Cancer] Investigators used patient-derived, typically resistant, glioma stem-like cells in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DNA damage response inhibitors.

[iScience] The authors demonstrated CD141+ dermal dendritic cells (DCs) and CD141hiVitD3 monocyte-derived DCs shared key immunological features including cell surface markers, reduced T cell stimulation, IL-10 production, and a common transcriptomic signature.

[Immunity] Scientists investigated whether disruption of the co-inhibitory receptors CTLA4 or PD-1 could restore CART function. CRISPR-Cas9-mediated deletion of CTLA4 in preclinical models of leukemia and myeloma improved CAR T cell proliferation and anti-tumor efficacy.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers found that CD8 tumor-infiltrating lymphocytes in both murine and human tumors exhibited overall similar phenotypic and transcriptional characteristics compared to corresponding subsets in the spleen of chronically infected mice.

[Nature Communications] Investigators explored, using live single-cell imaging, the cytotoxic functions of γδ T cells upon interactions with tumor target cells with high temporal and spatial resolution.

[Cell Reports] By analyzing >1,000 publicly available antibody-antigen structures, investigators showed that many V-gene allelic polymorphisms in antibody paratopes were determinants for antibody binding activity.

[Science Signaling] Different chemoattractants can drive qualitatively different modes of migration even though their receptors couple to the same Gαi family of G proteins. Th authors used live-cell imaging to demonstrate that the responses differed in their signaling dynamics.

[Signal Transduction And Targeted Therapy] The authors discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

[Nature Reviews Immunology] Scientists focus on the key obstacles pertaining to vaccine design and tumor environment that remain to be overcome in order to unleash the true potential of neoantigen vaccines in cancer therapy.