Keep Current with the Latest in Cell Biology Research

Monovalent Ions and Stress-Induced Senescence in Human Mesenchymal Endometrial Stem/Stromal Cells

[Scientific Reports] Human mesenchymal endometrium stem/stromal cells subjected to oxidative stress entered into premature senescence accompanied by persistent DNA damage, irreversible cell cycle arrest, increased expression of the cell cycle inhibitors cell hypertrophy, and enhanced β-galactosidase activity.

MiR-29a-3p Inhibits Proliferation and Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells via Targeting FOXO3 and Repressing Wnt/β-Catenin Signaling in Steroid-Associated Osteonecrosis

[International Journal of Stem Cells] Researchers investigated the role of miRNA-29a-3p (miR-29a-3p) in human bone marrow mesenchymal stem cells (hBMSCs), and its relationship with steroid-associated osteonecrosis.

Modulation of Osteogenic Differentiation of Adipose-Derived Stromal Cells by Co-Treatment with 3, 4’-Dihydroxyflavone, U0126, and N-Acetyl Cysteine

[International Journal of Stem Cells] Scientists investigated the effect of a flavonoid, 3, 4’-dihydroxyflavone on osteogenic differentiation of equine adipose-derived stromal cells .

Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids

[Advanced Science] Investigators found that overexpression of farnesoid X receptor (FXR), a main receptor for bile acids, improved the retention and cardioprotection of adipose tissue-derived MSC administered by intramyocardial injection in mice with myocardial infarction.

Translating MSC Therapy in the Age of Obesity

[Frontiers in Immunology] Investigators look to cancer immunotherapy as a model for the challenges MSCs may face in obese environments.

Hypoxic Condition Induced H3K27me3 Modification of the LncRNA Tmem235 Promoter Thus Supporting Apoptosis of BMSCs

[Apoptosis] H3K27me3 cooperated with LncRNA Tmem235 promoter DNA methylation to inhibit the expression of LncRNA Tmem235 and promoted the apoptosis of bone marrow MSCs.

Generation of Hyaline-Like Cartilage Tissue from Human Mesenchymal Stromal Cells within the Self-Generated Extracellular Matrix

[Acta Biomaterialia] Results indicated that human MSC-derived cartilage formed in hypoxic culture displayed a significantly reduced hypertrophy level than normoxic culture.

MicroRNA-25-3p Suppresses Osteogenic Differentiation of BMSCs in Patients with Osteoporosis by Targeting ITGB3

[Acta Histochemica] The authors investigated the impact of the miR-25–3p/integrin beta-3 (ITGB3) axis on the osteogenic differentiation of bone marrow MSCs from patients with osteoporosis.

EMF Promote BMSCs Differentiation and Functional Recovery in Hemiparkinsonian Rats

[Neuroscience Letters] Scientists focused on the EMF exposed multi-potential BMSCs which differentiated and successfully implanted in the substantia nigra pars compacta of Parkinson's disease rat model.

Researchers Pioneer a New Way to Detect Microbial Contamination in Cell Cultures

[Singapore-MIT Alliance for Research and Technology] Researchers from the Critical Analytics For Manufacturing Personalized-Medicine have developed a new method of detecting adventitious microbial contamination in MSC cultures, ensuring the rapid and accurate testing of cell therapy products intended for use in patients.

Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations

[Annual Review of Medicine] Mutations in the genes encoding erythropoietin (EPO), EPO receptor, HIF-2α, prolyl hydroxylase domain protein 2, or von Hippel–Lindau protein caused familial erythrocytosis.

Extramedullary Relapse of Acute Myeloid Leukemia in Brachial Plexus after Allogeneic Stem Cell Transplantation: A Case Report

[BMC Neurology] Scientists reported a case of extramedullary relapse of acute myeloid leukemia in the brachial plexus of a 41-year-old woman treated with allogeneic hematopoietic stem cell transplantation.

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