Researchers evaluated the ability of mast cells and MSCs to induce angiogenesis in a rat model of ischemic hind limb injury on a background of a tissue engineered hydrogel scaffold.
Scientists demonstrated that MSCs derived from oral squamous cell carcinoma (OSCC) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition.
The authors developed a cell- and growth factor-free approach to induce bone formation in a critical-size bone defect by using an interconnected porous beta-tricalcium phosphate scaffold with multiple channels.
Researchers investigated the mechanism driving a PARK7-mediated resistance to apoptosis in bone marrow MSCs and indicated that PARK7 promoted the disintegration of nuclear factor–like 2 (Nrf2)/Kelch-like echinacoside–associated protein 1 complex.
Investigators demonstrated preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte sheets produced from routine surgical discards using thermo-responsive cultureware.
TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.
Inspired by the composition and microstructure of natural bone, researchers developed a biphasic composite consisting of highly aligned strontium/copper-doped one-dimensional hydroxyapatite and poly(d,l-lactide).
DNA supramolecular hydrogel was applied as delivering material for MSCs to treat a severe osteoarthritis model, which performed extraordinary protection in MSCs against shear force both in vitro and in vivo.
Directed differentiation of human PSCs revealed that loss of One Cut Homeobox 1 (ONECUT1) impaired pancreatic progenitor formation and a subsequent endocrine program.
Researchers show that talin- and actomyosin-dependent mechanosensing of substrate rigidity controls microtubule acetylation by promoting the recruitment of α-tubulin acetyltransferase 1 to focal adhesions.
