Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. The authors discuss the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration.
Avidity Biosciences, Inc. announced that the US FDA has granted Fast Track Designation to its lead program, AOC 1001, for the treatment of myotonic dystrophy type 1.
Scientists found that localized injuries, as experienced through exercise, activated a myofiber self-repair mechanism that was independent of satellite cells in mice and humans.
Using human airway smooth muscle cells in culture as a model, the authors reported that activation of the cell surface β2-adrenoceptor, a Gs-coupled G protein-coupled receptor, evoked cAMP egress to the extracellular space.
[American Journal of Respiratory and Critical Care Medicine]
Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.
The genes mutated in primary hereditary microcephaly are ubiquitously expressed in proliferating cells, but under normal conditions are selectively required during brain development, in neural progenitors.
The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.
Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease.
The author summarizes key recent developments relevant to the pathologic diagnosis of lung neuroendocrine neoplasms, including carcinoids, small cell lung carcinoma, and large cell neuroendocrine carcinoma.
