Keep Current with the Latest in Cell Biology Research
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Inhibition of Stemness and PD-L1 Expression by Pien Tze Huang Enhances T Cell-Mediated Killing of Colorectal Cancer
[Journal of Ethnopharmacology] Investigators assessed the impact of Pien Tze Huang on colorectal cancer stem cells (CSCs), and evaluate the coordination effect of PZH on T cell-mediated anti-colorectal cancer with patient-derived autologous T cell co-culture.
Hydrogel PCDME Creates Pancreatic Cancer Stem Cells in OXPHOS Metabolic State with TXNIP Elevation
[Biochemical and Biophysical Research Communications] Researchers demonstrated that hydrogel PCDME could rapidly induce pancreatic cancer cell spheroids with elevated levels of stem cell markers including Sox2, Oct3/4, and Nanog, and the growth rate was reduced.
The Molecular Impact of miR-326 in Acute Lymphoblastic Leukemia and Its Cross Talk with P53
[Annals of Hematology] Scientists revealed that miR-326 exhibited a multifunctional anti-tumor behavior, affecting various aspects of drug resistance, stemness, and apoptosis in cancer, particularly in the context of acute lymphoblastic leukemia.
CREB1-BCL2 Drives Mitochondrial Resilience in RAS GAP-Dependent Breast Cancer Chemoresistance
[Oncogene] Researchers showed that RASAL2 was enriched following neoadjuvant chemotherapy in triple-negative breast cancer patients. This enrichment was specific to the tumor compartment compared to adjacent normal tissues, suggesting that RASAL2 upregulation is tumor-selective.
Triethylamine-Mediated Protonation–Deprotonation Unlocks Dual-Drug Self Assembly to Suppress Breast Cancer Progression and Metastasis
[Proceedings of The National Academy of Sciences of The United States of America] Scientists emphasized the significant clinical potential of DT as an innovative carrier-free nanomedicine and provided profound insights into the design of nanomedicines for cancer therapy.
Exosome Platform with Three-in-One Functionality of mRNA Therapy, Immune Checkpoint Blockade, and Mild Photothermal Therapy for the Treatment of Triple-Negative Breast Cancer
[ACS Applied Materials & Interfaces] Investigators presented a multifunctional nanotherapeutic platform designed to combine cytokine-sensitized mild photothermal therapy, immune checkpoint blockade (ICB), and interleukin-2 mRNA therapy to reprogram the tumor microenvironment, thereby improving the efficacy of ICB therapy in TNBC.
Genetic Advancements in Breast Cancer Treatment: A Review
[Discover Oncology] Personalized medicine, guided by genomic profiling, enhances treatment precision by identifying patient-specific mutations, such as BRCA1 and BRCA2, allowing for more tailored and effective interventions.
Kindlin-2-Mediated Hematopoiesis Remodeling Regulates Triple-Negative Breast Cancer Immune Evasion
[Molecular Cancer Research] Investigators focused on Kindlin-2, an adaptor protein, and its role in triple-negative breast cancer progression, particularly in hematopoiesis-mediated immune evasion.
ROS-Induced Cytosolic Release of Mitochondrial PGAM5 Promotes Colorectal Cancer Progression by Interacting with MST3
[Nature Communications] Using colorectal cancer models, investigators showed that upon sensing excessive mitochondrial reactive oxygen species, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein, becoming released into the cytoplasm.
Identification of the Immune Infiltration and Biomarkers in Ulcerative Colitis Based on Liquid–Liquid Phase Separation-Related Genes
[Scientific Reports] Researchers determined the seven high accuracy diagnostic genes of ulcerative colitis (UC) patients and provided a new perspective on immunoregulation in UC pathogenesis.
Oxidative Stress Caused by 3-Monochloro-1,2-Propanediol Provokes Intestinal Stem Cell Hyperproliferation and the Protective Role of Quercetin
[Ecotoxicology and Environmental Safety] Scientists revealed that exposure to 3-MCPD led to a decrease in the number of enterocyte cells and an elevation in apoptosis levels, ultimately disrupting the intestinal epithelial barrier and its function.
Akkermansia muciniphila Identified as Key Strain to Alleviate Gut Barrier Injury through Wnt Signaling Pathway
[eLife] Researchers showed that fecal microbiota transplantation regulated gut microbiota and enhanced the protection of AIMD piglets against Escherichia coli K88 challenge, as demonstrated by reduced intestinal pathogen colonization and alleviated gut barrier injury.