Keep Current with the Latest in Cell Biology Research

UNF Faculty Receive Patent for Discovering Cancer-Fighting Compound That Could ‘Turn Off’ Cancer

[University of North Florida] Three University of North Florida (UNF) researchers have been awarded a US patent for a targeted cancer-fighting compound, or peptoid, that the team has discovered targets certain breast, colon and lung cancers and stops them from progressing. This promising discovery could lead to significantly better patient outcomes for difficult to treat cancers.

Genetically Programmable Cell Membrane-Camouflaged Nanoparticles for Targeted Combination Therapy of Colorectal Cancer

[Signal Transduction and Targeted Therapy] Scientists introduced a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM nanoparticles (NPs). Notably, blocking CD47 with MPB-3BP@CM NPs enhanced the phagocytosis of colorectal cancer cells by macrophages.

Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

[Journal of Pharmaceutical Sciences] Researchers investigated the effects of passage and cryopreservation of enteroids, organoids derived from intestine. They focused on P-glycoprotein (p-gp) and compared the transfer rates of rhodamine 123 into the lumen of enteroids with and without a P-gp inhibitor.

ACLS4 Could Be a Potential Therapeutic Target for Severe Acute Pancreatitis

[Scientific Reports] The authors conducted a comprehensive transcriptomic analysis of peripheral blood from patients with acute pancreatitis (AP) and the pancreatic tissue from a mouse model of AP. In mouse models of severe AP, ACSL4 was significantly upregulated in the pancreas, whereas GALNT3, WSB1, and IL1R1 were not.

Human Gastric Cancer Progression and Stabilization of ATG2B through RNF5 Binding Facilitated by Autophagy-Associated CircDHX8

[Cell Death & Disease] Researchers investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in the malignancy of gastric cancer (GC). CircDHX8 was identified as upregulated and shown to enhance the malignant progression in GC cells by promoting cellular autophagy.

The Multifaceted Role of SOX2 in Breast and Lung Cancer Dynamics

[Pathology - Research and Practice] SOX2, known for its abnormal expression in various human cancers, can either accelerate or impede cancer progression. The authors focus on examining the role of SOX2 in breast and lung cancer development.

Generation of Salivary Glands Derived from Pluripotent Stem Cells via Conditional Blastocyst Complementation

[Cell Reports] Scientists identified the Foxa2 lineage as a critical lineage for salivary gland development through conditional blastocyst complementation.

Suppression of Smooth Muscle Cell Inflammation by Myocardin-Related Transcription Factors Involves Inactivation of TANK-Binding Kinase 1

[Scientific Reports] Researchers tested if myocardin-related transcription factors suppressed inflammation also by targeting cGAS-STING signaling. Interrogation of a transcriptomic dataset where myocardin was overexpressed using a panel of 56 cGAS-STING cytokines showed the panel to be repressed.

Direct RNA Sequencing of Astronaut Blood Reveals Spaceflight-Associated m6A Increases and Hematopoietic Transcriptional Responses

[Nature Communications] Scientists reported key genetic pathways, including changes in erythrocyte regulation, stress induction, and immune changes affected by spaceflight.

An Autoinhibitory Switch of the LSD1 Disordered Region Controls Enhancer Silencing

[Molecular Cell] The authors demonstrated how the intrinsically disordered region of the corepressor LSD1 excluded transcription factor association, acting as a dynamic conformational switch that tuned repression of active cis-regulatory elements.

Optimizing In Vitro T Cell Differentiation by Using Induced Pluripotent Stem Cells with GFP-RUNX1 and McHerry-TCF7 Labeling

[Cell Proliferation] Investigators established a fluorescence reporter hiPSC line in which the endogenous expression of RUNX1 and TCF7 were illustrated by the GFP and mCherry fluorescence, respectively.

iPS Cell Generation-Associated Point Mutations Include Many C > T Substitutions via Different Cytosine Modification Mechanisms

[Nature Communications] Researchers found through WGS analysis of human and mouse iPSC lines that genomic mutations were de novo events and that, in addition to unmodified cytosine base prone to deamination, the DNA methylation sequence CpG represented a significant mutation-prone site.

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