Keep Current with the Latest in Cell Biology Research

Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis

[Nature Cell Biology] Using intracranial injections in mice and assembloids between small-cell lung cancer (SCLC) aggregates and human cortical organoids in culture, the authors found that SCLC cells recruited reactive astrocytes to the tumor microenvironment.

Intraventricular SHH Inhibition Proves Efficient in SHH Medulloblastoma Mouse Model and Prevents Systemic Side Effects

[Neuro-Oncology] Infant medulloblastoma-bearing Math1-cre::Ptch1 Fl/Fl mice were treated with intraventricular Vismodegib in order to evaluate efficacy on tumor growth and systemic side effects.

Trametinib Activates Endogenous Neurogenesis and Recovers Neuropathology in a Model of Alzheimer’s Disease

[Experimental & Molecular Medicine] Investigators developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult mouse NSCs.

DNA Damage Response Inhibitors Enhance Tumor Treating Fields (TTFields) Potency in Glioma Stem-Like Cells

[British Journal of Cancer] Investigators used patient-derived, typically resistant, glioma stem-like cells in combination with the previously validated preclinical Inovitro TTFields system together with a number of therapeutic DNA damage response inhibitors.

Human Skin CD141+ Dendritic Cells Regulate Cutaneous Immunity via the Neuropeptide Urocortin-2

[iScience] The authors demonstrated CD141+ dermal dendritic cells (DCs) and CD141hiVitD3 monocyte-derived DCs shared key immunological features including cell surface markers, reduced T cell stimulation, IL-10 production, and a common transcriptomic signature.

Deletion of the Inhibitory Co-receptor CTLA4 Enhances and Invigorates Chimeric Antigen Receptor T Cells

[Immunity] Scientists investigated whether disruption of the co-inhibitory receptors CTLA4 or PD-1 could restore CART function. CRISPR-Cas9-mediated deletion of CTLA4 in preclinical models of leukemia and myeloma improved CAR T cell proliferation and anti-tumor efficacy.

Characteristics and Anatomic Location of PD-1+TCF1+ Stem-Like CD8 T Cells in Chronic Viral Infection and Cancer

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers found that CD8 tumor-infiltrating lymphocytes in both murine and human tumors exhibited overall similar phenotypic and transcriptional characteristics compared to corresponding subsets in the spleen of chronically infected mice.

Modulation of Lytic Molecules Restrain Serial Killing in γδ T Lymphocytes

[Nature Communications] Investigators explored, using live single-cell imaging, the cytotoxic functions of γδ T cells upon interactions with tumor target cells with high temporal and spatial resolution.

Widespread Impact of Immunoglobulin V-Gene Allelic Polymorphisms on Antibody Reactivity

[Cell Reports] By analyzing >1,000 publicly available antibody-antigen structures, investigators showed that many V-gene allelic polymorphisms in antibody paratopes were determinants for antibody binding activity.

Signaling Dynamics Distinguish High- and Low-Priority Neutrophil Chemoattractant Receptors

[Science Signaling] Different chemoattractants can drive qualitatively different modes of migration even though their receptors couple to the same Gαi family of G proteins. Th authors used live-cell imaging to demonstrate that the responses differed in their signaling dynamics.

Multifaceted Role of mTOR (Mammalian Target of Rapamycin) Signaling Pathway in Human Health and Disease

[Signal Transduction And Targeted Therapy] The authors discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

Challenges in Developing Personalized Neoantigen Cancer Vaccines

[Nature Reviews Immunology] Scientists focus on the key obstacles pertaining to vaccine design and tumor environment that remain to be overcome in order to unleash the true potential of neoantigen vaccines in cancer therapy.

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