It was widely assumed that SMAD4-mutant (SMAD4mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). Researchers scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4mut colorectal cancer cell lines.
The composition of the intestinal microbiota is associated with both the development of tumors and the efficacy of anti-tumor immunity. Researchers examined the impact of microbiota-specific T cells in anti-colorectal cancer immunity.
Researchers studied IL-8 secretion, as a marker of pro-inflammatory response through the Toll-like receptor (TLR) pathway, in a Caco-2 monoculture, Caco-2/HT29-MTX di-culture, Caco-2/HT29-MTX/HMVEC-d tri-culture and in a HT29-p monoculture in response to exposure to various TLR agonists.
Valerate, a short-chain fatty acids mainly converted from proteins or amino acids, was demonstrated to promote intestinal barrier function at its physiological concentrations of 0–4 mM in the Caco-2 cell monolayer model of intestinal barrier.
Scientists found that both Sirtuin 1 (SIRT1) and SIRT1 phosphorylated on serine 27 were coordinately upregulated in colon cancer patients’ tissues and human colon cancer cell lines.
Researchers outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment.
Researchers investigated the regulatory function of microRNA miR-145-5p in colon cancer (CC) cells. Bioinformatics analysis was used to screen key genes in CC.
Medtronic Canada ULC, announced that it has received a Health Canada licence for the GI Genius™ intelligent endoscopy module. GI Genius is a computer-aided detection system that uses artificial intelligence to highlight regions of the colon suspected to have visual characteristics consistent with different types of mucosal abnormalities.
Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.
