[Arteriosclerosis Thrombosis and Vascular Biology] The authors introduced a novel mechanism driving monocyte-mediated ECM remodeling in procalcific inflammatory responses through Wnt5a-CaMKII–activated secretion of MMP7⁺S100A8⁺ calcifying extracellular vesicle by CXCL4-induced proinflammatory monocytes.

[Cell Death & Disease] Researchers demonstrated that embryos apply forces remodeling the matrix with species-specific displacement amplitudes and distinct radial patterns: principal displacement directions for mouse embryos, expanding on the surface, while human embryos insert in the matrix, generating multiple traction foci.

[Biomaterials Science] Scientists optimized optical imaging and analysis protocols to overcome imaging challenges and enable quantitative assessments of decellularized ECM models, demonstrating a use case in engineered in vitro cancer microenvironments.

[Chinese Medical Journal] Investigators revealed that temozolomide exposure significantly elevated collagen type I expression in both glioblastoma patients and murine models.

[Cancer & Metabolism] Researchers emphasized the importance of glutamine metabolism inhibition in suppressing tumor growth and disrupting cancer-associated fibroblast-mediated crosstalk.

[Scientific Reports] Scientists showed that ECM stiffness induces changes in mammary epithelial cell metabolism which drive DNA damage.

[Journal of Leukocyte Biology] The authors review the potential utilization of matrix metalloproteinases (MMPs) as biomarkers for inflammatory bowel disease (IBD)/colorectal cancer (CRC) diagnosis, prognosis and treatment response. MMPs remain central to both IBD and CRC biology and present both challenges and opportunities for therapeutic intervention and disease monitoring.

[Gerogian Public Broadcaster] Georgia's Rare Disease Treatment Programme is being expanded. According to the Ministry of Health, the state will purchase inhalation preparations, antibiotics, vitamins and other medications for patients with cystic fibrosis.

[Cell Death Discovery] The authors review the emerging roles of N6-methyladenosine (m6A) regulators, including readers, writers, and erasers, and the downstream m6A-modified mRNA and noncoding RNA in prostate cancer.

[Molecular Oncology] Using prostate cancer cells overexpressing ETS variant 1 (ETV1) or ETS related gene, researchers unveiled a positive feedback loop between ETV1 and epidermal growth factor receptor (EGFR), with STAT3 acting as a downstream effector of ETV1–EGFR signaling.

[Apoptosis] Investigators synthesized advanced nanocapsules embedded with indocyanine green and conjugated with the Anti-hPSMA^{EC domain} to improve specificity towards prostate cancer cells.

[Cancer Research] Scientists functionally characterized the role of prospero-homeobox 1 (PROX1) in neuroendocrine prostate cancer (NEPC). An unbiased CRISPR screen in two NEPC patient-derived organoid models demonstrated high cellular dependency for PROX1.