[Nature Communications] Scientists employed a MSC specific CreERT2 line to express SS18::SSX in fibroblasts and related cell types, resulting in 100% penetrant synovial sarcoma development in mice. Murine tumours exhibited high concordance with human synovial sarcoma subtypes at the histological and molecular levels.

[Communications Biology] Investigators generated enucleated human umbilical cord-derived MSCs overexpressing CCR2 and IFN-γ, which retained essential organelles and exhibited immune regulatory, paracrine, and homing capabilities.

[Advanced Science] The authors generated a suite of genetic tools to distinguish MSCs between tissues, and to map their fate in local, proximate, and distal organ repair.

[Cell Death & Disease] The authors revealed the critical role of Fis1 in regulating mitochondrial dynamics and MSC osteogenesis in radiation-induced bone injury.

[Nature Biomedical Engineering] Researchers used mRNA engineering to create an off-the-shelf immunotherapy that they termed DC-25. DC-25 consists of a mesenchymal stem cell armed with three designed mRNA constructs.

[Advanced Healthcare Materials] Scientists demonstrated that MSCs cultured within 3D graphene foams can be transdifferentiated into Schwann cell-like phenotypes using the synergistic effects of electrical stimulation and 3D porous and conductive structure.

[Stem Cell Research & Therapy] Among the five types of stem cells that have been experimentally applied to liver diseases, MSCs have emerged as the most extensively studied, with the largest number of experimental and clinical research platforms worldwide.

[Longeveron, Inc. (The Canada Finance Journal)] Longeveron, Inc. announced that the Canadian Intellectual Property Office has granted a patent covering administration of laromestrocel for the treatment of patients with symptoms of aging-related frailty and also for the treatment of non-ischemic dilated cardiomyopathy.

[Nature] Scientists mapped and functionally profiled CD8⁺ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in broadly neutralizing anti-HIV-1 antibody (bNAb) recipients. CD8⁺ T cell stemness was further increased following bNAb administration without the emergence of new clonotypes targeting defined HLA-optimal epitopes.

[Nature Communications] Single-cell RNA-sequencing of primary human acute myeloid leukemia bone marrow identifies enrichment of leukemic stem cells within the FSC^low ALDH1A1⁺ subpopulation, which exhibits long-term stemness in functional assays.

[Advanced Science] Researchers showed that efferocytosis and associated polyamine metabolic reprogramming support the chemotherapy-induced enrichment of CSCs, providing new targets for addressing chemoresistance and recurrence of ovarian cancer.

[Advanced Science] Investigators demonstrated that CSCs play a pivotal role in suppressing CD103⁺ T cell differentiation in patients with non-small cell lung cancer.