Keep Current with the Latest in Cell Biology Research

Tumor-Derived CTF1 (Cardiotrophin 1) Is a Critical Mediator of Stroma-Assisted and Autophagy-Dependent Breast Cancer Cell Migration, Invasion and Metastasis

[Autophagy] Researchers identified CTF1/CT-1 as an activator of autophagy in fibroblasts and breast cancer-derived carcinoma-associated fibroblasts and they showed that CTF1 stimulated phosphorylation and nuclear translocation of STAT3.

The SKBR3 Cell-Membrane Proteome Reveals Telltales of Aberrant Cancer Cell Proliferation and Targets for Precision Medicine Applications

[Scientific Reports] Scientists explored the cell-membrane proteome of a HER2+ breast-cancer cell line to identify triggers responsible for uncontrolled cell proliferation and intrinsic resources that enable detection and therapeutic interventions.

Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple Negative Breast Cancer

[Advanced Materials] Scientists developed walking dead TNBC cells through conjugating anti-programmed death protein 1 inhibitor and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis.

Deubiquitinase OTUD6A Promotes Breast Cancer Progression by Increasing TopBP1 Stability and Rendering Tumor Cells Resistant to DNA-Damaging Therapy

[Cell Death & Differentiation] Investigators showed that deubiquitinase OTUD6A was involved in the DDR and was important to maintaining genomic stability.

A Potent Estrogen Receptor and Microtubule Specific Purine-Benzothiazole-Based Fluorescent Molecular Probe Induces Apoptotic Death of Breast Cancer Cells

[Scientific Reports] Using 2D-QSAR approach the authors have designed library of 15 molecules containing benzothiazole analogues that can detect breast cancer cell and inhibit its proliferation.

Ceritinib Is a Novel Triple Negative Breast Cancer Therapeutic Agent

[Molecular Cancer] Combination therapy of Ceritinib and Enzalutamide were investigated using androgen receptor positive breast cancer mouse xenograft models.

The Role of Epigenetic Modifications in Drug Resistance and Treatment of Breast Cancer

[Cellular & Molecular Biology Letters] The authors discuss the molecular and epigenetic mechanisms underlying breast cancer progression and resistance as well as various aspects of epigenetic-based therapies.

Co-expression of DDR2 and IFITM1 Promotes Breast Cancer Cell Proliferation, Migration and Invasion and Inhibits Apoptosis

[Journal of Cancer Research and Clinical Oncology] DDR2 and/or IFITM1 were knocked down in BT20 and MDA-MB-231 cells, after which the viability, mobility and apoptosis of the cells were tested.

Thymoquinone Upregulates IL17RD in Controlling the Growth and Metastasis of Triple Negative Breast Cancer Cells In Vitro

[BMC Cancer] Thymoquinone (TQ), a natural compound, has been found to be effective against TNBC cells, and scientists identified IL17RD as a novel target of TQ in TNBC cells.

MY11 Exerts Antitumor Effects through Activation of the NF-κB/PUMA Signaling Pathway in Breast Cancer

[Investigational New Drugs] MY11 inhibited the growth of MDA-MB-231 and MCF-7 breast cancer cells by arresting the cell cycle and promoting apoptosis, through regulation of the cell cycle and apoptosis-related proteins.

UBC Faculty of Medicine Honours Canadian Leading Researchers in Cancer, Heart and Brain Disorders

[UBC Faculty of Medicine] Three Canadian scientists have been recognized by UBC’s Faculty of Medicine for their outstanding scientific accomplishments, and for their potential to make further contributions in their fields.

An Optimized Method for Obtaining Clinical-Grade Specific Cell Subpopulations from Human Umbilical Cord-Derived Mesenchymal Stem Cells

[Cell Proliferation] Scientists established a general operation process for obtaining high-quality clinical-grade cell subpopulations from human umbilical cord MSCs based on particular markers.

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