Keep Current with the Latest in Cell Biology Research

Inhibiting β-Catenin Disables Nucleolar Functions in Triple-Negative Breast Cancer

Investigators demonstrated that LAS1 like ribosome biogenesis factor protein expression was significantly elevated in TNBC patients, and it functionally was important for mammary tumor growth in xenograft models and enabled invasive attributes.
[Cell Death & Disease]
Weeks, S. E., Kammerud, S. C., Metge, B. J., AlSheikh, H. A., Schneider, D. A., Chen, D., Wei, S., Mobley, J. A., Ojesina, A. I., Shevde, L. A., & Samant, R. S. (2021). Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03531-z Cite
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BCDIN3D RNA Methyltransferase Stimulates Aldolase C Expression and Glycolysis through Let-7 MicroRNA in Breast Cancer Cells

In order to uncover metabolic pathways regulated by BCDIN3D in cancer, we performed an unbiased analysis of the metabolome, transcriptome, and proteome of breast cancer cells depleted for BCDIN3D.
[Oncogene]
BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells | Oncogene. (n.d.). Retrieved March 4, 2021, from https://www.nature.com/articles/s41388-021-01702-y Cite
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Epithelial to Mesenchymal Transition and MicroRNA Expression Are Associated with Spindle and Apocrine Cell Morphology in Triple-Negative Breast Cancer

The authors analyzed miRNA expression within areas of TNBCs with cellular morphology that may be related to the epithelial to mesenchymal transition process and discuss possible associations.
[Scientific Reports]
Koleckova, M., Ehrmann, J., Bouchal, J., Janikova, M., Brisudova, A., Srovnal, J., Staffova, K., Svoboda, M., Slaby, O., Radova, L., Vomackova, K., Melichar, B., Veverkova, L., & Kolar, Z. (2021). Epithelial to mesenchymal transition and microRNA expression are associated with spindle and apocrine cell morphology in triple-negative breast cancer. Scientific Reports, 11(1), 5145. https://doi.org/10.1038/s41598-021-84350-2 Cite
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Allarity Therapeutics Initiates Phase II Trial of IXEMPRA® in Europe for the Treatment of Metastatic Breast Cancer

Allarity Therapeutics A/S announced that it has enrolled the first patient in its European Phase II clinical trial of IXEMPRA® for the treatment of metastatic breast cancer.
[Allarity Therapeutics A/S]
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Kintara Therapeutics Appoints Dr. Mario Lacouture to Scientific Advisory Board for Cutaneous Metastatic Breast Cancer

Kintara Therapeutics, Inc.announced the appointment of Mario Lacouture, to the REM-001 Scientific Advisory Board with the initial focus in Cutaneous Metastatic Breast Cancer.
[Kintara Therapeutics, Inc.]
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Involvement of Actin Cytoskeletal Modifications in the Inhibition of Triple Negative Breast Cancer Growth and Metastasis by Nimbolide

The authors demonstrated the growth and metastasis inhibitory potential of nimbolide on TNBC cells. Nimbolide inhibited cell proliferation, migratory, and invasive abilities of TNBC cells and also changed the shape of MDA-MB-231 cells, which is correlated with cytoskeletal changes including actin depolymerization.
[Molecular Therapy-Oncolytics]
Arumugam, A., Subramani, R., & Lakshmanaswamy, R. (2021). Involvement of actin cytoskeletal modifications in the inhibition of triple negative breast cancer growth and metastasis by nimbolide. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.02.014 Cite
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The Onco-Immunological Implications of F. nucleatum in Breast Cancer

Scientists discuss the breast tumor microbiota, its colonization by F. nucleatum, possible mechanisms by which F. nucleatum might promote breast cancer progression and how this might impact breast cancer treatment.
[Immunology Letters]
van der Merwe, M., Van Niekerk, G., Botha, A., & Engelbrecht, A.-M. (2021). The Onco-immunological Implications of F nucleatum in Breast Cancer. Immunology Letters. https://doi.org/10.1016/j.imlet.2021.02.007 Cite
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Be The Match BioTherapies® Announces Expansion of Multi-Year Strategic Alliance with Orchard Therapeutics to Support European Commercial Launch of Libmeldy™

Be The Match BioTherapies announced an expansion of their multi-year partnership with Orchard Therapeutics to include supply chain services in support of the upcoming commercial launch of Libmeldy™ (autologous CD34+ cells encoding the ARSA gene), Orchard’s gene therapy recently approved in Europe for the treatment of early-onset metachromatic leukodystrophy.
[Be The Match BioTherapies (BusinessWire, Inc)]
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Tempest Therapeutics Announces Clinical Collaboration with Roche to Advance TPST-1120 into a Randomized Combination Study in First-line Hepatocellular Carcinoma

Tempest Therapeutics, Inc. announced a clinical collaboration agreement with F. Hoffmann-La Roche Ltd. The collaboration will evaluate TPST-1120, Tempest’s small molecule PPAR⍺ antagonist, in combination with atezolizumab and bevacizumab in previously untreated patients with advanced hepatocellular carcinoma.
[Tempest Therapeutics, Inc.]
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CD8+ T-Cell Memory: The Why, the When, and the How

There is growing evidence that the molecular mechanisms that underpin the rapid effector function of memory T cells are also observed in innate immune cells such as macrophages and natural killer cells.
[Cold Spring Harbor Perspectives in Biology]
Turner, S. J., Bennett, T. J., & Gruta, N. L. L. (2021). CD8+ T-Cell Memory: The Why, the When, and the How. Cold Spring Harbor Perspectives in Biology, a038661. https://doi.org/10.1101/cshperspect.a038661 Cite
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Immune Cell Constitution in the Tumor Microenvironment Predicts the Outcome in Diffuse Large B-Cell Lymphoma

Investigators profiled the expression of 730 immune-related genes in tumor tissues of 81 patients with diffuse large B-cell lymphoma utilizing the Nanostring platform, and used multiplex immunohistochemistry to characterize T-cell phenotypes.
[Haematologica]
Autio, M., Leivonen, S.-K., Brück, O., Mustjoki, S., Jørgensen, J. M., Karjalainen-Lindsberg, M.-L., Beiske, K., Holte, H., Pellinen, T., & Leppä, S. (2021). Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. Haematologica, 106(3), 718–729. https://doi.org/10.3324/haematol.2019.243626 Cite
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