[Experimental & Molecular Medicine] Researchers investigated the role of unc-51-like kinase 1 (ULK1) using tissue-specific deletion in genetically engineered mouse models.

[Stem Cell Research & Therapy] Stepwise pancreatic β-cell differentiation protocols, designed to recapitulate key developmental milestones of pancreatic organogenesis—from definitive endoderm to mature, glucose-responsive β-cells—draw on insights from both rodent and human developmental biology.

[Nature Communications] Researchers showed that trophoblast organoids derived from human placentas constitutively express both IL-27 and its receptor, and restrict Zika virus infection through IL-27 signaling.

[Karolinska Institute] The Swedish Cancer Society has announced its research grants for 2025. Around 73 million has been awarded to researchers at the Department of Medical Epidemiology and Biostatistics at Karolinska Institute.

[Otago Daily Times] University of Otago pathology and molecular medicine researcher Dr. Jim Smith has received a Health Research Council grant to create a targeted DNA methylation-based blood test to detect prostate cancer earlier.

[Scientific Reports] Scientists demonstrated that CDC7 is highly expressed in treatment-resistant prostate cancer, with even higher levels observed in treatment-resistant prostate cancer with neuroendocrine phenotype.

[Journal of Experimental & Clinical Cancer Research] The authors explored the specific molecular mechanism by which docetaxel enhances immunotherapy, with the aim of providing new insights for the immunotherapy of prostate cancer patients.

[Cell Communication and Signaling] Researchers established docetaxel-resistant CRPC models and performed an epigenetic drug screen, identifying MLL-Menin and MLL-WDR5 inhibitors as potent agents capable of restoring taxane sensitivity through G2/M arrest and apoptosis induction.

[Iscience] Using a prostate cancer model mimicking the onset of castration-resistant and neuroendocrine phenotypes, researchers uncovered rapid lncRNA changes, with PROCA11 emerging as the most prominent.

[NPJ Breast Cancer] Investigators demonstrated that high poly(ADP-ribose) glycohydrolase (PARG) expression is associated with immune infiltrating in breast cancer and also influences cell proliferation, cell migration and invasion.

[Nature Communications] Scientists revealed 5hmC levels positively regulate MSC self-renewal and osteoblast differentiation.

[Advanced Healthcare Materials] Scientists employed biomaterial-based models, including multiple models of tissue-engineered skin and 3D epidermal organoids. These results revealed that regulating cell‒matrix adhesion between basal layer epidermal stem cells (EpSCs) and the basement membrane ECM promoted the function of EpSCs.