[Nature Communications] Researchers analyzed the susceptibility of neural tissue to monkeypox virus using human neural organoids exposed to a clade IIb isolate. They reported susceptibility of several cell types to the virus, including neural progenitor cells and neurons.

[Cell] Scientists co-differentiated mesoderm and endoderm within the same spheroid to vascularize lung and intestinal organoids from iPSCs.

[Nature Biomedical Engineering] Investigators presented a method for generating jawbone-like organoids from hiPSC through PA1 ectomesenchyme of the mandibular prominence.

[Scientific Reports] The authors reported an original, fully-human in vitro 3D model of the bone marrow microenvironment dedicated to study interactions taking place between mesenchymal stromal cells and hematopoietic stem and progenitor cells during the hematopoietic differentiation.

[Aging Cell] Scientists established cortical organoids derived from Hutchinson-Gilford progeria syndrome (HGPS) patient-iPSCs from patients with HGPS to investigate the role of progerin in the brain.

[Journal of Nanobiotechnology] The authors investigated the impact of maternal exposure to polypropylene nanoplastics on fetal brain development and neurobehavioral outcomes in a mouse model and further explored its mechanism in human cerebral organoids.

[UMass Chan Medical School] Megan Orzalli is one of eight recipients of the 2025 Investigators in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Fund.

[Science Signaling] Researchers tested the leucine-rich repeat kinase 2 (LRRK2) inhibitor MLi-2 in a mouse model of early stage, LRRK2 mutation–associated Parkinson's disease.

[Nature Communications] Scientists investigated the association between glial reactivity and synaptic dysfunction biomarkers in cerebrospinal fluid from 478 individuals in cognitively unimpaired and cognitively impaired individuals.

[Nature Communications] Using apolipoprotein M (Apom)^-/- mice, scientists showed that blood ApoM-sphingosine-1-phosphate (S1P) deficiency impairs the subventricular zone-NSC pool, neurogenesis, ependymal cell polarity, and cerebrospinal fluid flow.

[Nature Communications] Researchers identified microglial connexin43 hemichannels as a regulator of microglial reactivity in Alzheimer's disease, positioning them as a promising therapeutic target.

[Scientific Reports] To investigate the protective effects of rutin in imiquimod (IMQ)-induced psoriasis model mice and its underlying molecular mechanism, IMQ was applied to mice to induce inflammatory skin that phenotypically mimics psoriasis.