[Gilead Sciences, Inc. (BioSpace)] Gilead Sciences, Inc. announced that the European Commission has granted marketing authorization for Trodelvy® in combination with Keytruday® for the treatment of adult patients with unresectable, locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic disease.

[Science Advances] Researchers engineered a tunable hyaluronan-elastin-like protein hydrogel to independently control ligand presentation and matrix viscoelasticity. Using dynamic covalent chemistry, they developed hydrogels with matched stiffness but distinct stress relaxation profiles.

[Signal Transduction and Targeted Therapy] The authors synthesize how cancer-associated adipocytes and adipose dynamics drive oncogenesis, progression and therapeutic failure and highlight actionable nodes within the adipose–tumor axis for precision oncology.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed an activation of hepatic stellate cell-targeted nanocomplex to remodel a rigid fibrotic barrier. This platform inhibits the fibrotic process by inducing cellular senescence and activating endogenous immune surveillance.

[Cell Stem Cell] Scientists combined spatial and single-nucleus transcriptomics of patient spleens with spatial and single-cell transcriptomics, as well as imaging analyses, of murine spleens to map extramedullary hematopoiesis niches.

[Proceedings of the National Academy of Sciences of the United States of America] Using system glycobiology approaches, the authors reported that ST6GAL1 facilitates profound sialyl linkage switching within the glycocalyx upon tumor-associated macrophage (TAM) polarization.

[Molecular Oncology] Scientists discussed various epigenetic mechanisms controlling cancer cell-intrinsic states, cancer cell–TME crosstalk, current epigenetic therapies, and future research directions that may lead to the discovery of new biomarkers and the development of effective epigenetic anticancer therapeutics.

[iScience] Investigators used hydrogels to mimic physiological stiffnesses and examine how mechanical and biochemical ECM cues influence progesterone-induced differentiation (decidualization) in healthy fibroblasts.

[Advanced Healthcare Materials] Researchers described ‘hydroMEA,’ a 3D platform fabricated by placing polydimethylsiloxane microstructures on a high-density multielectrode array and filled with a desired hydrogel, to offer controlled topologies, physiologically relevant microenvironments, and real-time electrophysiological measurements.

[EMBO Molecular Medicine] Researchers identified telomeric DNA damage signaling as a driver of idiopathic pulmonary fibrosis, with targeted inhibition reversing key molecular and fibrotic features of disease.

[American Journal of Respiratory Cell and Molecular Biology] Scientists indicated that S100A2 is a key driver of epithelial dysfunction in lung fibrosis, promoting loss of alveolar type 2 epithelial (AT2) identity, aberrant basal fate acquisition, and persistent epithelial injury.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators demonstrated that nuclear protein 1 (NUPR1) inhibition exacerbates iron accumulation, enhances lipid peroxidation, impairs mitochondrial function, disrupts cellular metabolism, and increases oxidative stress in lung epithelial cells.