[ImmuneWalk Therapeutics] ImmuneWalk Therapeutics announced positive results from the POINTGUARD study evaluating subcutaneously administered IW-601, a highly selective biologic inhibitor of myeloid cell tissue infiltration. The study met all primary and secondary endpoints, demonstrating safety and tolerability of IW-601 at all doses.

[Journal of Experimental Medicine] Scientists reported that transcriptional repressor REV-ERB was critical for the differentiation and function of colonic RORγt+Foxp3+ Treg cells.

[JCI Insight] Scientists demonstrate that knocking down or inhibiting HDAC8 impaired murine Treg suppressive function in vitro and in vivo, but promoted conventional host T cell responses, thereby limiting syngeneic tumor growth.

[Science Translational Medicine] Scientists showed that ubiquitin-proteasome system disruption in alveolar type 2 epithelial cells amplifies profibrotic signaling to macrophages through macrophage migration inhibitory factor family proteins in several models.

[Molecular Therapy] Researchers identified circPTK2, a fibroblast-specific circular RNA that is significantly upregulated in pulmonary fibrosis patients and experimental models.

[Scientific Reports] Investigators presented a comprehensive workflow for the isolation and culture of primary human AT2 cells, including an efficient enzyme-based lung tissue digestion protocol and automated purification of human alveolar type 2 cells from both healthy and diseased lungs.

[Scientific Reports] The authors investigated the impact of KDM6B on macrophage processes during sepsis-induced acute lung injury and elucidated the underlying molecular mechanisms.

[Cell Research] Researchers performed whole-genome and transcriptome sequencing on 1008 lung adenocarcinoma samples from 954 patients who underwent surgery at Fudan University Shanghai Cancer Center, with comprehensive follow-up data.

[Science Advances] Scientists investigated the real-time link between oligomerization of oncogenic and resistant epidermal growth factor receptor (EGFR) mutants and downstream signaling using a fluorescent protein–based proximity probe and signaling reporter in living cells.

[Cell Reports] The authors identified the circular RNA circATF6, which is specifically downregulated in drug-tolerant persister cells due to regulation by the splicing factor ADAR1.

[Cell Death & Disease] Researchers found that centrosomal microtubule formation was increased in osimertinib-resistant NSCLC cells, and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) was identified as the key molecule responsible for the change of microtubule morphology.

[Biomedical Engineering Online] Investigators focus on the structure and the composition of supporting cells of organ-on-a-chip, whose most notable feature is its biomimetic representation of the human body.