IL-18R-Mediated HSC Quiescence and MLKL-Dependent Cell Death Limit Hematopoiesis during Infection-Induced Shock

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Using Ixodes ovatus Ehrlichia, a tick-borne pathogen that causes severe shock-like illness and bone marrow aplasia, type I and II interferons promoted the loss of hematopoietic stem progenitor cells via increased cell death and enforced quiescence.
[Stem Cell Reports]

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