IL-18R-Mediated HSC Quiescence and MLKL-Dependent Cell Death Limit Hematopoiesis during Infection-Induced Shock

Using Ixodes ovatus Ehrlichia, a tick-borne pathogen that causes severe shock-like illness and bone marrow aplasia, type I and II interferons promoted the loss of hematopoietic stem progenitor cells via increased cell death and enforced quiescence.