Prostate-Specific Oncogene OTUD6A Promotes Prostatic Tumorigenesis via Deubiquitinating and Stabilizing C-Myc

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Genetic ablation of OTUD6A efficiently repressed prostatic tumorigenesis of both human prostate cancer (PrCa) cells and the Hi-Myc transgenic PrCa mice, via reversing the metabolic remodeling caused by c-Myc overexpression in PrCa.
[Cell Death & Differentiation]

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Abstract