Glutathione peroxidase 2 (GPx2) loss stimulated malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1α inhibition.
[Proceedings of the National Academy of Sciences of the United States of America]
Sorry, but the selected Zotpress account can't be found.