Redox Signaling by Glutathione Peroxidase 2 Links Vascular Modulation to Metabolic Plasticity of Breast Cancer

Glutathione peroxidase 2 (GPx2) loss stimulated malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA signaling, causing poor perfusion and hypoxia, which were reversed by GPx2 reexpression or HIF1α inhibition.