In Vivo Imaging of Mammary Epithelial Cell Dynamics in Response to Lineage-Biased Wnt/β-Catenin Activation

Researchers showed that β-catenin stabilization, when targeted to either the mammary luminal or basal epithelial lineage, led to cellular rearrangements that precipitates the formation of hyperplastic lesions that underqwnt squamous transdifferentiation.