N⁶-Adenomethylation of GsdmC Is Essential for Lgr5⁺ Stem Cell Survival to Maintain Normal Colonic Epithelial Morphogenesis

Mettl14 ablation triggered apoptosis that depleted Lgr5+ stem cells and disrupted colonic organoid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and organoids.