Scientists tested the ability of THR-123, a cyclic peptide with BMP-7-like activity, to regenerate β-cell mass in diabetic mice. [Nature Communications] Full Article

Researchers showed that islet progenitors with distinct gene expression and DNA methylation patterns produced β-cell subtypes of different secretory function, proliferation rate, and viability...

[Molecular Cancer] Researchers identify two distinct but interconnected activin receptor-like kinase 7 (ALK7)-driven non-canonical pathways that promote PDAC dissemination.

[Science Advances] Integrating multicenter patient data and multi-omics, scientists reported that the misp53^R273H/C mutant is associated with cell cycle progression and a basal-like state compared to the misp53R248W/Q mutant.

[Gene] Scientists validated the role of origin recognition complex (ORC) 6 in PDAC and supported the hypothesis that the METTL3/IGF2BP3/ORC6/p53 axis may be a novel therapeutic target for PDAC, and inhibiting this axis may be an advantageous therapeutic strategy for curing PDAC.

[BMC Medicine] Investgigators assessed the safety, preliminary antitumor activity, and pharmacokinetics of HR070803 in combination with 5-FU/LV and oxaliplatin for treatment-naive patients with unresectable locally advanced or metastatic PDAC.

[Molecular Pharmaceutics] Researchers confirmed the overexpression of 5T4 protein in tumor samples of pancreatic adenocarcinoma compared with the corresponding paraneoplastic tissue.

[Molecular Carcinogenesis] Pancreatic cancer cells were exposed to increasing concentrations of nigericin at different time periods, and the corresponding 50% inhibiting concentration values were calculated.

[Gut] Scientists illustrated the mechanisms of resistance to trametinib in PDAC and identified trametinib resistance-associated druggable targets, thus improving the treatment efficacy of trametinib-resistant PDAC.

[Cell Death & Disease] Researchers reported that the expression of eukaryotic elongation factor-2 kinase (eEF2K) is associated with shorter patient survival and demonstrated that eEF2K signaling is critical for the PDAC tumor growth and is regulated by the tumor microenvironment.

[Journal of Translational Medicine] The authors discuss the current research progress regarding the function of type I collagen in PDAC tumors and summarize its contributions to PDAC progression, thus providing a basis for follow-up research and potential targets for cancer treatment.

[Biomarker Research] Researchers synthesize recent advancements in clinical proteomic techniques and applications, highlighting significant biomarker discoveries and signal transduction networks associated with pancreatic cacner.