Keep Current with the Latest in Cell Biology Research

Characterization of Perivascular Alveolar Epithelial Stem Cells and Their Niche in Lung Homeostasis and Cancer

[Stem Cell Reports] Scientists reported a CD44high subpopulation of alveolar type II stem cells characterized by increased expression of genes that regulated immune signaling even during steady-state homeostasis.

Environmental Pollutants Exposure-Derived Extracellular Vesicles: Crucial Players in Respiratory Disorders

[Thorax] PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders, and extracellular vesicles.

Current State of Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis

[Respiratory Research] The authors review the existing literature on the signaling pathways linked to the pathogenesis of idiopathic pulmonary fibrosis , both within national and international contexts.

Fibroblast Smad7 Induction Protects the Remodeling Pressure-Overloaded Heart

[Circulation Research] The effects of myofibroblast-specific Smad7 loss were studied in a mouse model of transverse aortic constriction, using echocardiography, histological analysis, and molecular analysis.

Multiple Roles for Hypoxia Inducible Factor 1-Alpha in Airway Epithelial Cells during Mucormycosis

[Nature Communications] Transcriptome analysis revealed that R. delemar infection induces the expression of many pro-inflammatory genes whose expression was significantly reduced by hypoxia inducible factor 1-alpha inhibition.

Entrectinib in ROS1-Positive Advanced Non-small Cell Lung Cancer: The Phase II/III BFAST Trial

[Nature Medicine] Investigators presented data from ROS proto-oncogene 1 (ROS1)-positive cohort. Patients ≥18 years of age with stage IIIB/IV, ROS1-positive NSCLC detected by liquid biopsies received entrectinib 600 mg daily.

Concurrent Loss of LKB1 and KEAP1 Enhances SHMT-Mediated Antioxidant Defence in KRAS-Mutant Lung Cancer

[Nature Metabolism] Using RNA-seq and metabolomics data from human NSCLC, the authors uncovered that LKB1 loss enhanced serine–glycine-one-carbon metabolism via serine hydroxymethyltransferase.

$18.5 Million U19 Grant Will Study B and T Memory Cells in Transplanted Lungs, Uteruses, and Kidneys

[University of Alabama at Birmingham] A five-year, $18.5 million grant will allow University of Alabama at Birmingham (UAB) researchers to investigate T and B tissue-resident memory cells in transplanted lungs, kidneys and uteruses of UAB patients.

Identification of the Cytoplasmic DNA-Sensing cGAS-STING Pathway-Mediated Gene Signatures and Molecular Subtypes in Prostate Cancer

[BMC Cancer] The 430 patients with prostate cancer from the TCGA database were included. They integrated 29 key genes involved in cGAS-STING pathway and analyzed differentially expressed genes and biochemical recurrence-free survival-related genes.

Non-Stem Cell Lineages as an Alternative Origin of Intestinal Tumorigenesis in the Context of Inflammation

[Nature Genetics] Scientist used paneth cells as a model of a fully differentiated and postmitotic intestinal lineage capable of dedifferentiation and tumor formation in the context of inflammation.

Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer

[Jama Oncology] In this single-arm phase II nonrandomized controlled trial for resectable PDAC including 46 patients, the 12-month progression-free survival (PFS) was 67%, which met the primary end point of a 12-month PFS of 50% or greater.

RCHY1 and OPTN: An E3-Ligase and an Autophagy Receptor Required for Melanophagy, Respectively

[Autophagy] An E3-ligase, RCHY1, and an autophagy receptor, optineurin (OPTN), were identified as being essential for melanophagy in the β-mangostin-treated B16F10 cell line.

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