[Advanced Science] The role of protein arginine methyltransferase 1 (PRMT1) was investigated in endothelial cells, particularly in the context of chronic obstructive pulmonary disease (COPD) pathogenesis.

[Molecular Carcinogenesis] Investigators found that SOAT1 was overexpressed in oral squamous cell carcinoma (OSCC) and promoted proliferation, migration, and invasion of OSCC cells.

[Science Advances] Researchers investigated how the sequential expression of neurogenin 3 (NGN3) and NEUROD1 affects their pioneering functions during pancreatic endocrine differentiation.

[International Journal of Obesity] The authors discuss the known literature on euglycemic ketoacidosis associated with GLP-1RA and the risk factors for the condition.

[FASEB Journal] Scientists observed that L-lactate upregulated RNA-binding protein 15 (RBM15) protein levels in non-small-cell lung cancer cell lines A549 and H23 in a time- and dosage-dependent manner.

[Advanz Pharma] Alvotech, Kashiv Biosciences LLC, and ADVANZ PHARMA, announced that the UK Medicines and Healthcare Products Regulatory Agency has accepted a marketing application for AVT23, a proposed biosimilar to Xolair®.

[Scientific Reports] Researchers evaluated the impact of Kaempferol 3-O-gentiobioside on inflammatory cytokine secretion and mucus overproduction in IL-13-stimulated airway epithelial cells and ovalbumin-induced allergic asthma mouse models.

[Gene Therapy] Researchers sought to optimize a novel, CpG-rich AAV8 vector, referred to as pVR59, designed for treating lipoprotein lipase deficiency.

[Sanofi] The US FDA is evaluating under priority review the regulatory submission of tolebrutinib to treat non-relapsing secondary progressive multiple sclerosis and to slow disability accumulation independent of relapse activity in adult patients.

[Nature Reviews Neuroscience] Neurodegenerative diseases are associated with impairments in autonomic function — the regulation of involuntary physiological processes. These autonomic impairments manifest in different ways and at different stages depending on the specific disease.

[Translational Psychiatry] Using cerebral organoids derived from the human iPSC cell line HPSI1213i-babk_2, scientists investigated cocaine-induced changes of the gene expression regulatory landscape at an early developmental time point.

[Bone Research] Male and female bone-forming organoids were compared to non-bone-forming organoids regarding their extracellular matrix composition, transcriptome, and secreted proteome signatures to directly link in vivo outcomes to quality metrics.