[Science Immunology] Using ablation of embryo-derived Langerhans cells in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, researchers found intrinsic intraepidermal heterogeneity.

[Nature Communications] Based on house dust mite-induced mice asthma models and human samples, the authors applied flow cytometry, parabiosis, in vivo imaging, and adoptive transplantation to confirm the persistence, migration, and function of CD45+lineage–CD90.2+NK1.1–NKp46–ST2–KLRG1+IL-17RB+ memory-like ILC2s.

[Journal of Allergy and Clinical Immunology] Scientists utilized a tetracycline-inducible system to express IL-33 in the esophagus by generating two transgenic mice.

[EMBO Journal] Investigators performed single-cell RNA transcriptomics on endometrial stromal cells and decidual stromal cells and found that cell senescence during decidualization was accompanied by increased levels of the branched-chain amino acid transporter SLC3A2.

[Proceedings of The National Academy of Sciences of The United States of America] Using single-cell RNA-Seq in a mouse model, researchers determined the transcriptomic profiles and functions of different macrophages within endometriosis lesions and in the peritoneal cavity.

[Proceedings of The National Academy of Sciences of The United States of America] In order to determine the type of cells in which cGAS activation drives autoinflammation, the authors generated conditional cGAS knockout mice on the three prime repair exonuclease 1 (TREX1)-/- background.

[Journal for ImmunoTherapy of Cancer] Single-cell sequencing and flow cytometry analysis showed that tumor tissues from endosialin knockout mice had increased CD8+ T cell infiltration.

[Science Signaling] Scientists showed that high abundance of the transmembrane glycoprotein CD98hc in tumor cells and serum small extracellular vessicles was associated with extranodal natural killer/T cell lymphoma progression and drug resistance.

[Nature Reviews Gastroenterology & Hepatology] Investigators discuss the basic mechanisms of sex disparity in hepatic immune regulation and how these mechanisms influence and modify the development of autoimmune liver diseases, genetic liver diseases, portal hypertension and inflammation in chronic liver disease.

[Nature Reviews Rheumatology] The authors argue that mucosal sites and their associated microbial strains can contribute to rheumatoid arthritis evolution via distinct pathogenic mechanisms, which can be considered causal mucosal endotypes.

[Vironexis Biotherapeutics] Vironexis Biotherapeutics lauched with unveiling its TransJoin™ AAV Gene Therapy Platform and a pipeline of more than ten product candidates for blood-based cancers, solid tumor metastasis prevention, and a cancer vaccine.

[Cancer Gene Therapy] The authors presented the first evidence that caveolin-1 knockout in mammary epithelial cells significantly reduced lung metastasis in syngeneic breast cancer mouse models.