[EMBO Journal] Using a variety of in vitro and in vivo techniques, researchers showed that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion.

[Molecular Cell] Investigators explored the role of minor intron-containing genes and minor spliceosome in cancer, taking prostate cancer as an exemplar.

[Nature Communications] The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.

[Biofabrication] Scientists developed a novel bioink for the three-dimensional bioprinting of a coculture model that could be used to investigate the effect of hyaluronic acid on prostate cancer (PCa) behaviors and the mechanism underlying PCa-fibroblasts interaction.

[Phytotherapy Research] To elucidate antitumor mechanism of Morusin, cytotoxicity assay, cell cycle analysis, Western blotting, TUNEL assay, RNA interference, immunofluorescense, immunoprecipitation, reactive oxygen species measurement, and inhibitor study were applied.

[Translational Oncology] Using a two-tier phenotypic screening platform, researchers identified bromocriptine mesylate as a potent and selective inhibitor of chemoresistant prostate cancer cells.

[Cellular Signalling] Scientists investigated the molecular action of triiodothyronine (T3) on the ERAD mechanism and unfolded protein response signaling in prostate cancer cells and also extensively examined the effect of T3 on androgenic signaling.

[Scientific Reports] To identify genes that modulated treatment response to these drugs, the authors performed three genome-wide CRISPR/Cas9 knockout screens in the metastatic CRPC cell line C4.

[American Journal Of Physiology-Cell Physiology] Investigators examined the androgen independent human prostatic cancer cell line PC3 and find functional expression of proteinase-activated receptor 1 (PAR1) and PAR2 but not PAR4.

[Journal Of Biomolecular Structure & Dynamics] Researchers investigated the activity of the natural compound piperine on prostate cancer cell line, followed by exploring its mechanistic inhibition on the RAC-alpha serine/threonine-protein kinase (AKT1) protein.

[Cancer Biology & Medicine] The authors discuss the origin, hierarchy, and plasticity of prostate cancer stem cells (PCSCs) and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance.

[University of Birmingham] Adults and children with cancer will continue to benefit from world-class clinical trials led by the University of Birmingham thanks to a new £10 million grant from Cancer Research UK.