Keep Current with the Latest in Cell Biology Research

Lipid Nanoparticles and siRNA Targeting Plasminogen Provide Lasting Inhibition of Fibrinolysis in Mouse and Dog Models of Hemophilia A

[Science Translational Medicine] The authors developed a long-lasting antifibrinolytic using small interfering RNA targeting plasminogen packaged in clinically used lipid nanoparticles and tested it to determine whether reducing plasmin activity in animal models of hemophilia A could decrease bleeding frequency and severity.

An Engineered Baculoviral Protein and DNA Co-Delivery System for CRISPR-Based Mammalian Genome Editing

[Nucleic Acids Research] Using protein-loaded baculovirus, the authors demonstrated delivery of Cas9 or base editors proteins, leading to efficient genome and base editing in human cells.

Ex Vivo Expansion of Hematopoietic Stem Cells in Two/ Three-Dimensional Co-Cultures with Various Source of Stromal Cells

[Tissue And Cell] The capacity of mesenchymal stem cells derived from different sources to support the expansion and maintenance of HSPC was compared with each other.

Integrative Single-Cell Expression and Functional Studies Unravels a Sensitization to Cytarabine-Based Chemotherapy Through HIF Pathway Inhibition in AML Leukemia Stem Cells

[Hemasphere] Scientists identified HIFhigh and HIFlow specific AML subgroups and provided a comprehensive single-cell expression atlas of 119,000 AML cells and AML-leukemia stem cells in paired diagnostic-relapse samples from these molecular subgroups.

Improving Hematopoietic Differentiation from Human Induced Pluripotent Stem Cells by the Modulation of Hippo Signaling with a Diarylheptanoid Derivative

[Stem Cell Research & Therapy] Researchers utilized a defined cocktail of cytokines without serum or feeder followed by the supplementation of ASPP 049 to produce hematopoietic stem/progenitor cells.

Case Report of Pediatric TTMV-Related Acute Promyelocytic Leukemia with Central Nervous System Infiltration and Rapid Accumulation of RARA-LBD Mutations

[Heliyon] Investigators presented a pediatric case that manifested as PML::RARA-negative acute promyelocytic leukemia with central nervous system involvement at onset. The patient experienced both intramedullary and extramedullary relapse one year after undergoing allogeneic hematopoietic stem cell transplantation.

Efficacy and Safety of Azacitidine in Pediatric Patients with Newly Diagnosed Advanced Myelodysplastic Syndromes Before Hematopoietic Stem Cell Transplantation in the AZA-JMML-001 Trial

[Pediatric Blood & Cancer] Scientists reported efficacy, pharmacokinetics, and safety data obtained in treatment-naive, pediatric patients with newly diagnosed advanced myelodysplastic syndromes receiving azacitidine in the AZA-JMML-001 study.

How CBX Proteins Regulate Normal and Leukemic Blood Cells

[FEBS Letters] The authors describe how chromobox (CBX) proteins dictate age-related changes in HSCs and stimulate oncogenic HSC fate decisions, either as canonical polycomb repressive complex 1 members or by alternative interactions, including non-epigenetic regulation.

Two Very Rare COVID Vaccine Side-Effects Detected in Global Study of 99 Million

[The Guardian] Two new but exceptionally rare Covid-19 vaccine side effects – a neurological disorder and inflammation of the spinal cord – have been detected by researchers in the largest vaccine safety study to date.

circRNA_SLC8A1 Promotes the Survival of Mycobacterium tuberculosis in Macrophages by Upregulating Expression of Autophagy-Related Protein SQSTM1/p62 to Activate the NF-κB Pathway

[Scientific Reports] Researchers found that miR-20b-5p expression was decreased, while sequestosome 1 (SQSTM1) protein expression was increased in a time- and dose-dependent manner in the human macrophage U937 in response to Mycobacterium tuberculosis infection.

RNA m6A Methylation and Regulatory Proteins in Pulmonary Arterial Hypertension

[Hypertension Research] Scientists explored the mechanism and function of m6A in the pathogenesis of pulmonary arterial hypertension (PAH) and discuss the potential targeting of RNA m6A methylation modification as a treatment for PAH.

Extracellular Vesicles As Potential Biomarkers for Diagnosis and Recurrence Detection of Hepatocellular Carcinoma

[Scientific Reports] A prospective single-center cohort study including 37 HCC patients and 20 patients with non-malignant liver disease, as a control group, was conducted.

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