[Diabetes Obesity & Metabolism] The authors investigated the expression, functional, and metabolic characteristics of T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) + B cells in type 1 diabetes patients and non-obese diabetic mice using flow cytometry.

[Elife] Scientists used a rapid, scalable system to identify both cell-autonomous and non-cell-autonomous regulators of normal melanocyte development.

[Oncogene] Researchers showed that leucine zipper like transcription regulator 1 (LZTR1) regulates the ubiquitin proteasome system in melanoma cells and also associates with actin-related proteins and actin cytoskeleton organization.

[Translational Psychiatry] Researchers found that nesfatin-1 treatment improved cellular senescence in brain vascular endothelial bEnd.3 cells by restoring the expression of hTERT and TERF2 against oligomerized Aβ_1-42.

[Science Translational Medicine] A Phase I randomized trial in patients undergoing upper extremity arteriovenous fistula (AVF) placement was performed to evaluate the safety and efficacy of autologous adipose–derived MSCs in improving AVF function.

[Oncogene] Chromasomal instability can lead to abnormal gene expression, cellular senescence, and inflammation, altering MSCs.

[Stem Cell Research & Therapy] The authors elucidate the complex relationship between IL-17 A and MSCs in immune regulation, and to provide a theoretical foundation and new insights for the development of immunotherapy strategies based on MSCs in the future.

[Molecular Cancer Therapeutics] Scientists summarize the preclinical studies on bromodomain and extraterminal (BET) inhibition and discusses clinical trial activity, providing insights into the potential of BET inhibitors in sarcoma therapy.

[Blood] Researchers equip iNKT with CD19- and/or CD133-targeting CARs and investigate their anti-leukamia activity against KMT2A-rearranged acute lymphoblastic leukemia in relevant in vitro and in vivo models.

[Nature Communications] Researchers revealed that both genetic and pharmacological inhibition of mono-ADP-ribosyl hydrolase MacroD1 alleviates myocardial metabolic impairment, inflammation, dysfunction, and the risk of mortality caused by lipopolysaccharide and cecal ligation and puncture.

[Advanced Science] Scientists observed that muscle-specific ribosomal protein S27-like (Rps27l) knock-in mice exhibit significantly increased muscle mass, enlarged myofiber size, a higher proportion of fast-twitch myofibers, and enhanced muscle regeneration capabilities compared to wild-type controls.

[Diabetes & Metabolism Journal] Apolipoprotein E-knockout mice were intraperitoneally injected streptozotocin for five days and fed a high-fat diet for 12 weeks for establishing an in vivo diabetic atherosclerosis model.