Danielle Corrigan

Intestinal Cell News

Nanoparticle-Induced Chemoresistance: The Emerging Modulatory Effects of Engineered Nanomaterials on Human Intestinal Cancer Cell Redox Metabolic Adaptation

[Nanoscale] Investigators screened several representative food-borne comparator engineered nanomaterials and reported that human colon cancer cells could insidiously exploit ZnO nanoparticle-induced adaptive response to acquire resistance against several chemotherapeutic drugs.

Intestinal Cell News

NudCD1 as a Prognostic Marker in Colorectal Cancer and Its Role in the Upregulation of Cellular Spindle Assembly Checkpoint Genes and LIS1 Pathways

[BMC Cancer] Scientists investigated the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.

Intestinal Cell News

Repurposing Metformin as a Potential Treatment for Inflammatory Bowel Disease: Evidence from Cell to the Clinic

[International Immunopharmacology] Scientists discuss the beneficial effects of metformin on IBD using the results of in vitro, in vivo, and clinical studies.

Hepatic Cell News

Transcriptional Switch of Hepatocytes Initiates Macrophage Recruitment and T-Cell Suppression in Endotoxemia

[Journal of Hepatology] The spatial and temporal changes in hepatocytes and non-parenchymal cell types were validated by multiplex immunofluorescence staining, bulk transcriptomic sequencing, or flow cytometry.

Hepatic Cell News

TIPE1 Promotes Liver Regeneration by Enhancing Ros-FoxO1 Axis Mediated Autophagy

[FEBS Journal] Hepatic Tipe1 deficiency decreased the level of reactive oxygen species in hepatocytes, which led to the inhibition of FoxO1 acetylation and LC3I to LC3II conversion, and p62 accumulation.

Hepatic Cell News

Knockdown of Hepatocyte Perilipin-3 Mitigates Hepatic Steatosis and Steatohepatitis Caused by Hepatocyte CGI-58 Deletion in Mice

[Journal of Molecular Biology] Scientists test whether the deletion of a major lipid droplet protein alleviates fatty liver pathogenesis caused by alpha/beta hydrolase domain containing 5 deficiency in hepatocytes.

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Calcitonin Receptor Downregulation and Exercise-Conditioned Blood Enable Systemic Muscle Stem Cell Proliferation

[Nature Communications] Researchers found that increased loading reduces calcitonin receptor (CalcR) expression, and forced activation of protein kinase A, a downstream of CalcR signaling, suppresses muscle stem cell proliferation.

Orphan Broadly RBD-Binding Antibodies Annotate Three Remaining Conserved RBD Epitopes along SARS-CoV-2 Evolution

[Nature Communications] Using a heterogeneous double-bait single B-cell sorting strategy, investigators identified a subset of antibodies with broad-spectrum receptor-binding domain (RBD) binding, including recognition of SARS-CoV-1 and emerging variants such as EG.5.1, BA.2.86, JN.1, and KP.2/3.

Conserved CD8 T Cell Vaccines without B Cell Epitopes Drive Robust Protection against SARS-CoV-2 That Is Enhanced by Intranasal Boost

[Science Advances] Researchers identified both Omicron BA.1–specific and ancestral–conserved CD8 T cell epitopes in the SARS-CoV-2 spike protein and evaluated them as carrier-protein fusion vaccines in mouse models.

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Danielle Corrigan

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