Jamie Kang

Extracellular Matrix News

Androgen Dysregulates the Follicular Extracellular Matrix and Increases Pro-Fibrotic Gene Expression in the Mouse Ovary

[Scientific Reports] PCOS is characterized by hyperandrogenism and, here, scientists investigated the impact of androgens on fibrosis, cell-ECM interactions and mechanosensing. They reported an altered network of gene expression related to the genesis of fibrosis.

Extracellular Matrix News

Choline Attenuates Bilirubin Induced Effects on Tyrosine Phosphorylation and Distribution in Lipid Rafts of L1 Cell Adhesion Molecule In Vivo

[Pediatric Research] Choline supplementation ameliorates the biochemical effects of bilirubin on L1 cell adhesion molecule in vivo on choline-deficient hyperbilirubinemic jj Gunn rat pups.

Extracellular Matrix News

Fibroblasts As Regulators of Lung Immunity, Repair, and Fibrosis

[Nature Reviews Immunology] The authors show how loss of stromal regulation through chronic inflammation, immune dysfunction, altered tissue biomechanics and metabolic stress can tip the balance from successful tissue repair to progressive fibrosis.

Extracellular Matrix News

PureTech Announces Orphan Drug Designations Granted by the US Food and Drug Administration and European Commission for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis

[PureTech Health (Businesswire)] PureTech Health announced that the US FDA and European Commission have granted Orphan Drug Designation to deupirfenidone for the treatment of idiopathic pulmonary fibrosis, a rare, progressive, and fatal lung disease.

Muscle Cell News

Microfluidic Modeling of Macrophage-Induced Cardiac Inflammation Using NF-κB Reporter Cardiomyocytes

[Advanced Healthcare Materials] Researchers developed an in vitro cardiac inflammation model that enables controlled investigation of macrophage-cardiomyocyte interactions.

Muscle Cell News

Empagliflozin Protects against Doxorubicin-Induced Arrhythmia by AMPK/mTOR-Mediated Autophagy in Cardiomyocyte

[European Journal of Pharmacology] Investigators demonstrated that empagliflozin reduced the incidence of ventricular arrhythmia by regulating AMPK/mTOR signaling and restored autophagic flux in DOX-treated rats and neonatal rat ventricular cardiomyocytes.

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ANKRD1 Sustains a Neurogenic BMSC Niche and Counters Cognitive Aging

[International Journal of Oral Science] Researchers explored a neural crest-like progenitor niche in bone marrow MSCs with high neurogenic and proliferative capacity by single-cell transcriptomics.

Fusogenic Hybrid Gelled Nanovesicles Combining Mesenchymal Stromal Cell Cargo with Cholesterol-Modified Macrophage Membranes for Targeted Myocardial Infarction Therapy

[ACS Nano] Scientists developed a hybrid gelled nanovesicle, Hy-gNVs@chol, through chitosan-based protein enrichment and functional membrane replacement, enabling efficient concentration of MSC components to form gel nanoparticles while conferring inflammation-targeting capability.

Global Metabolomics Identifies New Extracellular Biomarkers of Nanovibration-Driven Mesenchymal Stem Cells Osteodifferentiation

[Biomaterials Advances] As part of an effort to eliminate synthetic osteogenic compounds, the authors characterized the metabolic adaptations of MSC to chemical-free nanovibration-induced osteodifferentiation.

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Jamie Kang

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