Justin.choi

[Nature Communications] Scientists identified a scaffold protein SH3RF3 that was upregulated in CSCs of breast cancer clinical tumors and cancer cell lines, and enhanced the CSC properties of breast cancer cells.

[Scientific Reports] Researchers found SOX2 expression signifies poor recurrence-free survival and correlates with advanced pathological grade in bladder cancer. SOX2 silencing attenuated bladder cancer cell growth, while its expression promoted cancer cell survival and proliferation.

[Cell Stem Cell] The authors found increased mRNA expression of mitochondrial intermembrane assembly pathway substrates in acute myeloid leukemia stem cells.

[Cell Stem Cell] Researchers showed integrin-linked kinase, a key constituent of focal adhesions, is highly expressed in TKI-nonresponsive patient cells and their LSCs.

[Journal of Clinical Medicine] The authors summarize the role of L1CAM in cancer focusing on its functional contribution to CSC pathophysiology.

[National Comprehensive Cancer Network] The National Comprehensive Cancer Network® and the NCCN Foundation® announced five new recipients for the 10th annual NCCN Foundation Young Investigator Awards Program.