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[Tissue Engineering Part A] ESC lines were treated with the ALK-5 inhibitor SB431542; HADC100 cells were additionally treated with ALK-5 inhibitors SB525334 or GW788388. Cells were then seeded upon human fibronectin in the presence of fibroblast growth factor 2 in a serum-free medium.

[Stem Cell Research & Therapy] To establish a peri-implant fibrosis model, customized silicone implants were inserted into the dorsal site of C57BL/6 wild-type mice. Adipose-derived stem cells were harvested from the fat tissues of transgenic mice that expressed a green fluorescent protein and then injected into the peri-implant space of recipient mice.

[Nature Communications] Investigators showed that ZFP266 bound Short Interspersed Nuclear Elements adjacent to binding sites of pioneering factors, OCT4 (POU5F1), SOX2, and KLF4, and impeded chromatin opening.

[ScienceInsider] The science committee of Indonesia’s Parliament is calling on the nation’s president to fire the head of its embattled research agency, following extensive controversy over the government’s efforts to consolidate research programs under the National Research and Innovation Agency.

[Stem Cell Reviews And Reports] To induce the differentiation of hiPSCs into oocyte-like cells, cells were firstly cultured with a primordial germ cell medium for 10 days. The cells exhibited similar morphological features to primordial germ cells, high expressing of germ cell markers and primordial follicle development associated genes.

[International Journal Of Biochemistry & Cell Biology] Researchers address H2A-DUB functions in epigenetic regulation of mammalian development and tissue maintenance by conducting a meta-analysis of 248 genomics datasets from 32 independent studies, focusing on the mouse model and covering ESCs, hematopoietic, and immune cell lineages.