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Hepatic Cell News

Reproducible Generation of Human Liver Organoids (HLOs) on a Pillar Plate Platform via Microarray 3D Bioprinting

[Lab On A Chip] Microarray 3D bioprinting, a droplet-based printing technology, was used to generate a large number of small organoids on the pillar plate for predictive hepatotoxicity assays.

Extracellular Matrix News

Biomimetic Hydrogels with Mesoscale Collagen Architecture for Patient-Derived Tumor Organoids Culture

[Bioactive Materials] Investigators presented a rapid technique for generating collagen bundles with an average length of 90 ± 27 μm and a mean diameter of 5 ± 1.5 μm from tumor tissue debris that underwent mechanical agitation following enzymatic digestion.

Newsletters

Breast Cancer-on-Chip for Patient-Specific Efficacy and Safety Testing of CAR-T Cells

[Cell Stem Cell] Researchers developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture over a period of up to eight days.

Newsletters

Rigor and Reproducibility in Human Brain Organoid Research: Where We Are and Where We Need to Go

[Stem Cell Reports] Investigators review current analytical platforms used to characterize human forebrain cortical organoids, highlight challenges, and propose recommendations for future studies to achieve greater precision and uniformity across laboratories.

Newsletters

Organoid Bioinks: Construction and Application

[Biofabrication] Scientists provide a rigorous, focused examination of the evolution and impact of organoid bioprinting. It emphasizes the role of organoid bioinks that integrate key cellular components and microenvironmental cues to more accurately replicate native tissue complexity.

Newsletters

T. Boone Pickens’ Posthumous Donation to Fund ‘Organoid’ Research Among Other Hotchkiss Brain Institute Programs

[CTV News] A legacy gift to a specialized centre at the University of Calgary's Cumming School of Medicine will fund emerging research that includes creating miniature-brain-like cells, called "organoids."

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Extracellular Vesicles Promote Migration despite BRAF Inhibitor Treatment in Malignant Melanoma Cells

[Cell Communication and Signaling] Researchers elucidated the involvement of extracellular vesicles (EV) in malignant melanoma progression and ascertained whether EV-mediated metastasis promotion persisted during single agent BRAF or MEK and combined BRAF/MEK inhibition.

Cholesterol Neutralized Vemurafenib Treatment by Promoting Melanoma Stem-Like Cells via Its Metabolite 27-Hydroxycholesterol

[Cellular and Molecular Life Sciences] Scientists found that lowering intracellular cholesterol by knocking down DHCR24, the limiting synthetase, impaired tumor cell proliferation and migration and abrogated the ability to xenotransplant tumors.

Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway

[Cell Proliferation] In-depth analysis of the expression of key molecules in the Wnt/β-catenin signaling pathway revealed that melatonin up-regulated the Wnt/β-catenin signaling pathway in dermal papillae, whereas these effects were facilitated through mediating Wnt ligand expression levels in the hair follicle stem cells.

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