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Cancer Stem Cell News
Genetic and Phenotypic Profiling of Single Living Circulating Tumor Cells from Patients with Microfluidics
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers described the nanoplatform for interrogating living cell host-gene and (micro-)environment relationships, that integrates micro- and nanofluidics to enable highly efficient capture of circulating tumor cells from blood samples.
Cancer Stem Cell News
Circadian Regulation of Cancer Stem Cells and the Tumor Microenvironment During Metastasis
[Nature Cancer] The authors review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis.
Cancer Stem Cell News
Identification of a Set of Genes Potentially Responsible for Resistance to Ferroptosis in Lung Adenocarcinoma Cancer Stem Cells
[Cell Death & Disease] The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and, therefore, protection against ferroptotic cell death.
Extracellular Matrix News
Development of a Novel High-Throughput Culture System for Hypoxic 3D Hydrogel Cell Culture
[Scientific Reports] As a proof-of-concept, investigators established a 3D culture of gelatin-methacryloyl-encapsulated mesenchymal stem/stromal cells.
Cell Therapy News
CD3 Aptamers Promote Expansion and Persistence of Tumor-Reactive T Cells for Adoptive T Cell Therapy in Cancer
[Molecular Therapy - Nucleic Acids] To identify CD3-specific T cell agonists, several RNA aptamers were selected against CD3 using SELEX combined with high-throughput sequencing.
Cell Therapy News
Selective Refueling of CAR T Cells Using ADA1 and CD26 Boosts Antitumor Immunity
[Cell Reports Medicine] Scientists presented a metabolic refueling approach using inosine as an alternative fuel. CAR T cells were engineered to express membrane-bound CD26 and cytoplasmic adenosine deaminase 1 (ADA1), converting adenosine to inosine.
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Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...
[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.
Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs
[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.
Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’
[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.
