Laurisa Dohm

Dermal Cell News

Green Cocoon-Derived Sericin Reduces Cellular Damage Caused by Radiation in Human Keratinocytes

[Scientific Reports] Researchers investigated the effects of green cocoon-derived sericin on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction.

Dermal Cell News

Collagen I Protects Human Keratinocytes HaCaT against UVB Injury via Restoring PINK1/Parkin-Mediated Mitophagy

[Archives Of Biochemistry And Biophysics] Cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis.

Dermal Cell News

ANKRD1 Is a Mesenchymal-Specific Driver of Cancer-Associated Fibroblast Activation Bridging Androgen Receptor Loss to AP-1 Activation

[Nature Communications] Investigators identified ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct androgen receptor negative control in human dermal fibroblasts and a key driver of cancer-associated fibroblasts conversion, independent of cellular senescence.

Dermal Cell News

Saracatinib Inhibits Necroptosis and Ameliorates Psoriatic Inflammation by Targeting MLKL

[Cell Death & Disease] In an imiquimod-induced psoriasis mouse model, saracatinib effectively blocked mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory responses in vivo.

Dermal Cell News

Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation

[JCI Insight] Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion.

Dermal Cell News

Nuclear Mechanotransduction on Skin Stem Cell Fate Regulation

[Current Opinion In Cell Biology] Scientists focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance.

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HepaRegeniX Doses First Patient in Phase Ib Trial with Small Molecule Inhibitor HRX-215 to Promote Liver Regeneration

[HepaRegeniX (GlobeNewswire)] HepaRegeniX announced that the first patient has been dosed in their Phase Ib clinical trial of its lead candidate HRX-215. The trial is evaluating the safety and efficacy of HRX-215, an orally available small-molecule inhibitor of MKK4, in patients undergoing partial liver resection due to liver metastases deriving from colorectal cancer.

US FDA Approves Expanded Indication for AbbVie’s MAVYRET® (Glecaprevir/Pibrentasvir) as First and Only Treatment for People with Acute Hepatitis C Virus

[AbbVie ] AbbVie announced that the US FDA approved a label expansion for MAVYRET^®, an oral pangenotypic direct acting antiviral therapy. It is now approved for the treatment of adults and pediatric patients three years and older with acute or chronic hepatitis C virus infection without cirrhosis or with compensated cirrhosis.

Small Molecule- and Cell Contact-Inducible Systems for Controlling Expression and Differentiation in Mouse Embryonic Stem Cells

[Development] Researchers presented an approach for rapid engineering of multiple inducible systems into mESCs. Small molecule- and cell contact-inducible systems work reliably and efficiently for controlling expression of arbitrary genetic payloads.

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Laurisa Dohm

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