Laurisa Dohm

Hematopoiesis News

SHP-1 Inhibition Targets Leukemia Stem Cells to Restore Immunosurveillance and Enhance Chemosensitivity by Metabolic Reprogramming

[Nature Cell Biology] The authors demonstrated that inhibition of tyrosine phosphatase SHP-1 in leukemia stem cells increased their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.

Hematopoiesis News

Leukemia Exposure Alters the Transcriptional Profile and Function of BCR::ABL1 Negative Macrophages in the Bone Marrow Niche

[Nature Communications] Scientists used a chimeric mouse model of chronic myeloid leukaemia and human bone marrow (BM) derived macrophages to study the impact of the dysregulated BM microenvironment on bystander macrophages.

Hematopoiesis News

BCR/ABL-Positive Chronic Myeloid Leukemia in Children: Current Treatment Approach

[Current Oncology Reports] The authors summarize the most updated treatment recommendations for pediatric chronic myeloid leukemia, and to discuss current areas of investigation.

Hematopoiesis News

Safety and Efficacy of Autologous Hematopoietic Stem-Cell Transplantation with Low-Dose Cyclophosphamide Mobilisation and Reduced Intensity Conditioning Versus Standard of Care in Refractory Crohn’s Disease...

[Lancet Gastroenterology and Hepatology] Participants were centrally randomly assigned, 2:1, to either HSCT with a reduced dose of cyclophosphamide (intervention group) or standard care (control group).

Hematopoiesis News

Mitapivat Improves Ineffective Erythropoiesis and Iron Overload in Adult Patients with Pyruvate Kinase Deficiency

[Blood Advances] Mitapivat's impact on iron overload and ineffective erythropoiesis was evaluated in adults with pyruvate kinase deficiency who were not regularly transfused in the Phase III ACTIVATE trial and long-term extension.

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A Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis

[Gastroenterology] The authors introduced FixNCut, a scRNA-seq approach where tissue is reversibly fixed with dithiobis(succinimidyl propionate) prior to dissociation and single-cell preparation. They applied FixNCut to an established mouse model of acute pancreatitis.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Laurisa Dohm

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