mladbrook

Dermal Cell News

VDAC1 Negatively Regulates Melanogenesis through the Ca2+-Calcineurin-CRTC1-MITF Pathway

[Life Science Alliance] Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway.

ROS-Triggered Nanoinducer Based on Dermatan Sulfate Enhances Immunogenic Cell Death in Melanoma

[Journal of Controlled Release] Scientists proposed a nanoinducer based on a functional dermatan sulfate (DS) for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative as functional grafting unit and doxorubicin designed as an immunogenic cell death inducer.

Embigin is a Fibronectin Receptor that Affects Sebaceous Gland Differentiation and Metabolism

[Developmental Cell] Using skin as a model system and combining single-cell RNA-seq data analysis, immunofluorescence, and transgenic mouse models, investigators showed that the transmembrane protein embigin is specifically expressed in the sebaceous gland and that the number of embigin-expressing cells is negatively regulated by Wnt.

The PTP4A3 Inhibitor KVX-053 Reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virulence, Inflammation, and Development of Acute Lung Injury in K18-hACE2 Mice

[Respiratory Research] Researchers investigated the efficacy of KVX-053, a protein tyrosine phosphatase type IVA (PTP4A3) small molecule inhibitor, in modulating SARS-CoV-2-induced inflammation and lung injury using in vitro cell models and in vivo K18-hACE2 transgenic mice.

LINC01198 Activates Hippo Signaling to Stimulate IL-1β Autocrine for Driving Vemurafenib Resistance by Associating with TAOK1/2 in Melanoma

[Cell Death Discovery] Scientists established vemurafenib-resistance melanoma cell strain together with acute vemurafenib treatment and characterized LINC01198 as the only one LncRNA up-regulated in both of stable vemurafenib-resistant and acute vemurafenib-treated melanoma cells.

Molecular Glue Degrader Function of SPOP Enhances STING-Dependent Immunotherapy Efficacy in Melanoma Models

[Journal of Clinical Investigation] Scientists revealed that SPOP targeted the innate immune sensor STING for degradation in a CK1γ phosphorylation-dependent manner to promote melanoma growth.

All Articles by Author:

mladbrook

Popular