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VDAC1 Negatively Regulates Melanogenesis through the Ca2+-Calcineurin-CRTC1-MITF Pathway

[Life Science Alliance] Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway.

ROS-Triggered Nanoinducer Based on Dermatan Sulfate Enhances Immunogenic Cell Death in Melanoma

[Journal of Controlled Release] Scientists proposed a nanoinducer based on a functional dermatan sulfate (DS) for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative as functional grafting unit and doxorubicin designed as an immunogenic cell death inducer.

Embigin is a Fibronectin Receptor that Affects Sebaceous Gland Differentiation and Metabolism

[Developmental Cell] Using skin as a model system and combining single-cell RNA-seq data analysis, immunofluorescence, and transgenic mouse models, investigators showed that the transmembrane protein embigin is specifically expressed in the sebaceous gland and that the number of embigin-expressing cells is negatively regulated by Wnt.

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia

[New England Journal of Medicine] Investigators enrolled patients from a compassionate-use program and those from a Phase I study who had primary multirefractory autoimmune hemolytic anemia. Each patient received a single infusion of autologous CD19 CAR T cells.

CD4+ T Cells Mediate CAR-T Cell-Associated Immune-Related Adverse Events after BCMA CAR-T Cell Therapy

[Nature Medicine] Among 198 patients treated with ciltacabtagene autoleucel or idecabtagene vicleucel, 27 developed CAR T cell therapy-associated immune-related adverse events (CirAEs). This included one remarkable case with three distinct CirAEs in association with an extreme CD4⁺ CAR T cell expansion.

Contaminating Plasmid Sequences and Disrupted Vector Genomes in the Liver following Adeno-Associated Virus Gene Therapy

[Nature Medicine] Scientists conducted a case study of a child with spinal muscular atrophy type 1 experiencing substantial hepatitis after receiving onasemnogene abeparvovec, undertaking long- and short-read metagenomic sequencing of liver tissue.

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