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Pulmonary Cell NewsAll Articles by Author:
Noshin Noorjahan
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Mapping the Developmental Potential of Mouse Inner Ear Organoids at Single-Cell Resolution
[iScience] Researchers used single-cell sequencing to study the cellular heterogeneity of late-stage mouse inner ear organoid sensory epithelia, which they validated by comparison with data sets of the mouse cochlea and vestibular epithelia.
Immune Regulation News
Microbiota-Derived Butyrate Restricts Tuft Cell Differentiation via Histone Deacetylase 3 to Modulate Intestinal Type 2 Immunity
[Immunity] Investigators examined the impact of the microbiota on tuft cell biology in the intestine. Succinate induction of tuft cells and type 2 innate lymphoid cells was elevated with loss of gut microbiota.
Immune Regulation News
Precise CRISPR-Cas9 Gene Repair in Autologous Memory T Cells to Treat Familial Hemophagocytic Lymphohistiocytosis
[Science Immunology] The authors used an adeno-associated virus–based CRISPR-Cas9 system with an inhibitor of nonhomologous end joining to repair such mutations in potentially long-lived T cells ex vivo.
Immune Regulation News
The Immunology of Type 1 Diabetes
[Nature Reviews Immunology] The authors provide an overview of the immune mechanisms that underpin the pathogenesis of type 1 diabetes, with a particular emphasis on T cells.
Muscle Cell News
Influence of Skeletal Muscle and Intermuscular Fat on Postoperative Complications and Long-Term Survival in Rectal Cancer Patients
[Journal Of Cachexia Sarcopenia And Muscle] This retrospective cohort study included patients with rectal cancer who underwent surgical resection. CT images within 3 months prior to the surgery were used to quantify the indices of skeletal muscle and adipose tissue at the levels of the third lumbar vertebra and umbilicus.
Human Immunology News
CD57-Positive CD8+ T Cells Define the Response to Anti-Programmed Cell Death Protein-1 Immunotherapy in Patients with Advanced Non-Small Cell Lung Cancer
[npj Precision Oncology] Single-cell mass cytometry was utilized to analyze immune cell subsets in peripheral blood mononuclear cells obtained from non-small cell lung cancer patients before and 12 weeks after single-agent immunotherapy.
Popular
ApoE4 Disrupts Intracellular Trafficking and Iron Homeostasis in a Reproducible iPSC-Based Model of Human Brain Endothelial Cells
[Stem Cell Reports] The authors developed a reproducible protocol for induced pluripotent stem cells based on a defined chemical cocktail and extracellular matrix support to differentiate brain endothelial cells.
Isolation of Endothelial Progenitor Cells from Human Adipose Tissue
[International Journal of Obesity] Omental and subcutaneous adipose tissue (AT) specimens were obtained during abdominal surgery. Following AT digestion with collagenase, both the filtered and unfiltered stromal vascular fractions of AT were used.
Mitochondrial-Encoded Peptide MOTS-C Prevents Pancreatic Islet Cell Senescence to Delay Diabetes
[Experimental & Molecular Medicine] Scientists showed that mitochondrial ORF of the 12S rRNA type-c (MOTS-c) levels decrease with aging and senescence in pancreatic islet cells. Treating aged C57BL/6 mouse pancreatic islets with MOTS-c reduced pancreatic islet senescence by modulating nuclear gene expression and metabolites involved in β-cell senescence.
