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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8
[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.
VC-Resist Glioblastoma Cell State: Vessel Co-Option as a Key Driver of Chemoradiation Resistance
[Nature Communications] Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, organotypic cultures, functional assays, animal studies, and clinical data analyses, we demonstrate that chemoradiation and brain vasculature induce cell transition to a functional state named VC-Resist.
The pRb/RBL2-E2F1/4-GCN5 Axis Regulates Cancer Stem Cell Formation and G0 Phase Entry/Exit by Paracrine Mechanisms
[Nature Communications] Investigators used a quantitative proteomic approach for identifying secreted proteins of CSCs in pancreatic cancer. They uncovered that the cell-autonomous E2F1/4-pRb/RBL2 axis balanced non-cell-autonomous signaling in healthy ductal cells but became deregulated upon KRAS mutation.
Macrophage-Fibroblast JAK/STAT Dependent Crosstalk Promotes Liver Metastatic Outgrowth in Pancreatic Cancer
[Nature Communications] Scientists identified three functionally distinct metastasis-associated fibroblast populations, among which the generation of pro-metastatic and immunoregulatory myofibroblastic-MAFs critically depended on macrophages.
Autonomous Circadian Rhythms in the Human Hepatocyte Regulate Hepatic Drug Metabolism and Inflammatory Responses
[MIT News] Investigators established and characterized an in vitro liver experimental system in which primary human hepatocytes display self-sustained oscillations.
METTL14 Downregulation Drives S100A4+ Monocyte-Derived Macrophages via MyD88/NF-κB Pathway to Promote MAFLD Progression
[Signal Transduction And Targeted Therapy] In vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner, which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1+Ccr2+ monocyte-derived macrophages.
Precise Capture and Dynamic Release of Circulating Liver Cancer Cells with Dual-Histidine-Based Cell Imprinted Hydrogels
[Advanced Materials] Scientists design an ultra-strong ligand, L-histidine–L-histidine, specifically targeting sialylated glycans on the surface of circulating tumor cells.
Bortezomib Suppresses Acute Myelogenous Leukemia Stem-Like KG-1a Cells via NF-κB Inhibition and the Induction of Oxidative Stress
[Journal Of Cellular And Molecular Medicine] Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like properties.
Integrated Drug Profiling and CRISPR Screening Identify BCR::ABL1-Independent Vulnerabilities in Chronic Myeloid Leukemia
[Cell Reports Medicine] The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors.
Dutch Cancer Society Grant to Study How Fatty Liver Disease Can Contribute to Liver Cancer
[Hubrecht Institute] Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer Society.
Oncolytic Herpes Simplex Virus Expressing IL-2 Controls Glioblastoma Growth and Improves Survival
[Journal For Immunotherapy Of Cancer] The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment (TME). They then tested its efficacy in orthotopic mouse GBM models and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
