Cell Therapy News

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Current Understanding and Management of CAR T Cell-Associated Toxicities

May 23, 2024

[Nature Reviews Clinical Oncology] Continued prospective evaluation of toxicity management strategies and the design of less-toxic CAR T cell products are both crucial for ongoing success in this field. The authors discuss the evolving understanding and clinical management of CAR T cell-associated toxicities.

ERS Genomics and IRBM Sign CRISPR/Cas9 License Agreement

May 23, 2024

[IRBM] ERS Genomics Limited and IRBM, announced a non-exclusive CRISPR/Cas9 license agreement. The agreement grants IRBM access to ERS’ CRISPR/Cas9 patent portfolio.

Closing the Gender Health Gap Is a $1 Trillion Opportunity

May 23, 2024

[Biopharma Dealmakers] For centuries, women’s health has been neglected across science, medicine and technology. A new report from the World Economic Forum suggests tackling this could unlock a $1 trillion economic boost with the potential to change the lives of 3.9 billion women.

City of Hope Awarded $5.4 Million CIRM Grant to Create a Stem Cell Laboratory and Expand Access to State-of-the-Art Disease Models and Technology Among...

May 23, 2024

[City of Hope] City of Hope, one of the largest cancer research and treatment organizations in the United States, has been awarded $5.4 million from the California Institute for Regenerative Medicine (CIRM) to build and fund a stem cell research laboratory on its Duarte, California, campus that will further expand its scientific capabilities.

Development of a Nucleoside-Modified mRNA Vaccine Against Clade 2.3.4.4b H5 Highly Pathogenic Avian Influenza Virus

May 23, 2024

[Nature Communications] Scientists generated an mRNA lipid nanoparticle (LNP) vaccine encoding the hemagglutinin (HA) glycoprotein from a clade 2.3.4.4b H5 isolate. The H5 mRNA-LNP vaccine elicits strong T cell and antibody responses in female mice, including neutralizing antibodies and broadly-reactive anti-HA stalk antibodies.

Parkinson’s Patient Moves Freely Again after World-First Implant of Lab-Grown Cells Into His Brain

May 22, 2024

[STEM-PD] Researchers at Lund University have successfully implanted 7 million lab-grown brain cells into a patient to treat Parkinson's disease. Swedish resident Thomas Matsson was the first in the world to test the method about a year ago

Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

May 17, 2024

[Science Immunology] Investigators performed single-cell multi-omics sequencing of paired cerebrospinal fluid and blood samples from patients with neuromyelitis optica spectrum disorder treated with anti–B cell maturation antigen (BCMA) CAR T cells.

Unveiling the Proteome-Wide Autoreactome Enables Enhanced Evaluation of Emerging CAR-T Therapies in Autoimmunity

May 17, 2024

[European Journal Of Clinical Investigation] Researchers leveraged advances in programmable-phage immunoprecipitation methodology to explore the modulation, or lack thereof, of autoantibody profiles, proteome-wide, in both health and disease.

Arming Vδ2 T Cells With Chimeric Antigen Receptors to Combat Cancer

May 17, 2024

[Clinical Cancer Research] Following a comprehensive overview of γδ T cell biology and innovative CAR engineering strategies, investigators discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.

Engineered CRISPR-Cas12a for Higher-Order Combinatorial Chromatin Perturbations

May 17, 2024

[Nature Biotechnology] Investigators engineered an Acidaminococcus Cas12a (AsCas12a) variant, multiplexed transcriptional interference AsCas12a, that incorporated R1226A, a mutation that stabilized the ribonucleoprotein–DNA complex via DNA nicking.

Global Effort Aims to Protect Health and Safety of Human ‘Guinea Pigs’ in Drug Trials

May 16, 2024

[Science Insider] Over the past two years, an international group of ethicists, scientists, regulators, and other stakeholders has sought ways to better protect people who join trials as paid, healthy volunteers rather than as patients hoping for an effective treatment.

Atrial Arrhythmias Following CAR-Chimeric Antigen Receptor T Cell Therapy: Incidence, Risk Factors and Biomarker Profile

May 16, 2024

[British Journal Of Haematology] The authors conducted a pharmacovigilance study to assess the reporting of atrial arrhythmias following CD19-directed CAR-T.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.