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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Spatial Analysis of Recurrent Glioblastoma Reveals Perivascular Niche Organization
[JCI Insight] The authors analyzed matched primary and recurrent GBM archival tumor tissues with imaging-based techniques aimed to simultaneously evaluate tumor tissues for presence of hypoxic, angiogenic, and inflammatory niches, extracellular matrix organization, TERT promoter mutational status, and several oncogenic amplifications on the same slide and location.
Matriglycan Maintains T-Tubule Structural Integrity in Cardiac Muscle
[Proceedings of The National Academy of Sciences of The United States of America] Researchers showed that dystroglycan (DG) was essential for maintaining cardiac t-tubule structural integrity. Mice with defects in O-glycosylation of DG developed normal t-tubules but were susceptible to stress-induced t-tubule loss or severing.
Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas
[Clinical Cancer Research] Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks. Subgroup analysis was performed in leiomyosarcomas, dedifferentiated liposarcomas and undifferentiated pleiomorphic sarcomas.
VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer
[Cancer Research] The authors showed that pancreatic cancer cells engage in autocrine asoactive intestinal peptide (VIP) signaling through VIP receptor 2 (VPAC2). High co-expression of VIP with VPAC2 correlated with reduced relapse-free survival in PDAC patients.
Boost for Research Aiming to Cure Chronic Diseases in an Aging Population
[University Medical Center Utrecht (EurekAlert!)] The DRIVE-RM consortium, led by Professor of Experimental Nephrology Marianne Verhaar from UMC Utrecht, has been awarded €37.5 million under the prestigious NWO SUMMIT program for regenerative medicine using smart materials.
Oncocross Expands Collaboration with JW Pharmaceutical on Developing Innovative New Drugs Using AI in Anticancer and Regenerative Medicine
[Oncocross (BusinessWire, Inc.)] Oncocross, a Seoul-based AI drug discovery and development biotech, announced on May 22nd that it has signed a joint research agreement with JW Pharmaceutical to develop new drugs based on the AI platform.
Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy
[Circulation] Researchers investigated whether cardiovascular magnetic resonance radiomics analysis can distinguish between noncollagen and inflammation from collagen in dilated cardiomyopathy.
Current Understanding of the Interplay Between Extracellular Matrix Remodelling and Gut Permeability in Health and Disease
[Cell Death Discovery] The authors bring together the current knowledge of the interplay between gut barrier, immune and ECM features in health and disease, discussing the role of barrier permeability as a discriminant between homoeostasis and Inflammatory Bowel Disease.
Immunohistochemical Properties of Embryonic Telocytes in a Myogenic Microenvironment
[Scientific Reports] Researchers investigated the immunohistochemical features of embryonic telocytes during myogenesis and describe their morphology using light microscopy and TEM.
3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP-Mg Nanoparticles for the Infectious Bone Defects Repair
[Small] Scaffolds mimicked the structure and components of cancellous bone with high mechanical strength based on α-TCP self-curing properties through low-temperature 3D printing.
Lgr6-Expressing Functional Nail Stem-Like Cells Differentiated From Human-Induced Pluripotent Stem Cells
[PLOS One] Investigators achieved the successful differentiation of nail stem-like cells from human-iPSCs via digit organoids by stepwise stimulation, tracing the molecular processes involved in limb development.
Enhancing Cellular Behavior in Repaired Tissue via Silk Fibroin-Integrated Triboelectric Nanogenerators
[Microsystems & Nanoengineering] Scientists presented a flexible silk fibroin-based triboelectric nanogenerator that featured an on-skin substrate and is characterized by excellent skin compliance and air/water permeability.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
