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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Initial COVID-19 Severity Influenced by SARS-CoV-2-Specific T Cells Imprints T-Cell Memory and Inversely Affects Reinfection
[Signal Transduction and Targeted Therapy] Investigators longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by severity. They found that early and robust SARS-CoV-2-specific CD4+ and CD8+ T cell responses ameliorate disease progression and shortened hospital stay, while delayed and attenuated virus-specific CD8+ T cell responses are prominent severe COVID-19 features.
The Alarmin IL-33 Exacerbates Pulmonary Inflammation and Immune Dysfunction in SARS-CoV-2 Infection
[iScience] Researchers observed that IL-33, a damage-associated molecular pattern molecule, was significantly increased in COVID-19 patients and in SARS-CoV-2-infected mice.
Checkpoint Inhibition Enhances Cell Contacts Between CD4+ T Cells and Hodgkin-Reed-Sternberg Cells of Classic Hodgkin Lymphoma
[Haematologica] Investigators showed for the first time by imaging of native lymphoma tissue an enhanced interaction of CD4+ T cells and Hodgkin-Reed-Sternberg cells in classic Hodgkin lymphoma after Nivolumab administration.
Immune Cell Profiles Associated with Human Exposure to Perfluorinated Compounds (PFAS) Suggest Changes in Natural Killer, T Helper and T Cytotoxic Cell Subpopulations
[Environmental Research] Associations of serum levels of common perfluorooctanoic acid, perfluorooctane sulfonic acid, perfluorononanoic acid, and perfluorohexane sulfonic acid and immune cell profiles of peripheral blood mononuclear cells, both with and without immunostimulation, were investigated.
Circadian Control of Tumor Immunosuppression Affects Efficacy of Immune Checkpoint Blockade
[Nature Immunology] Researchers used a single-cell RNA sequencing approach and a genetic model of colorectal cancer to identify clock-dependent changes to the immune landscape that control the abundance of immunosuppressive cells and consequent suppression of cytotoxic CD8+ T cells.
The Immune System Can Sabotage Gene Therapies — Can Scientists Rein It In?
[Nature News] The field of gene therapy has blossomed over the past decade, generating a stream of official approvals for various treatments and a burgeoning pipeline of clinical trials. But the inability to administer more than one dose of a virus carrying restorative genes limits what gene therapy can do.
Donor/Recipient Rh-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation: Transfusion Strategy and Allo-Immunization to Red Blood Cell Antigens
[Bone Marrow Transplantation] In this single-center retrospective study, the incidence of donor/recipient Rh incompatibility was 7.1% over an 8-year period including 1012 allogeneic hematopoietic stem cell transplantation.
Neuropsychiatric Prodromes and Symptom Timings in Relation to Disease Onset and/or Flares in SLE: Results From the Mixed Methods International INSPIRE Study
[eClinicalMedicine] Researchers investigated the timings of onset of a broad range of neuropsychiatric (NP) symptoms in relation to the timing of systemic lupus erythematosus onset. They explored whether NP symptoms may be a prodrome to SARD onset and subsequent flares.
Immunometabolism in Atherosclerotic Disorders
[Nature Cardiovascular Research] The authors provide a comprehensive summary of the metabolic reprogramming that occurs in immune cells and their progenitors during cardiovascular diseases, offering insights into the potential therapeutic interventions to mitigate disease progression.
Brain Cancer Canada Awards an $80,000 Research Grant to the Development of Dual Function Therapies That Harness the Body’s Own Immune System to Kill...
[Brain Cancer Canada] Brain Cancer Canada is excited to announce $80,000 research grant has been awarded to Dr. Peter Stirling, PhD, Associate Professor at the University of British Columbia and Senior Scientist at the Terry Fox Laboratory, BC Cancer.
Gut Microbial Metabolite Targets HDAC3-FOXK1-Interferon Axis in Fibroblast-Like Synoviocytes to Ameliorate Rheumatoid Arthritis
[Bone Research] Researchers showed that transplantation of fecal microbiota of collagen-induced arthritis (CIA)-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice. C57BL/6J mice and healthy human individuals have enriched B. fragilis than DBA/1J mice and rheumatoid arthritis patients.
Closing the Gender Health Gap Is a $1 Trillion Opportunity
[Biopharma Dealmakers] For centuries, women’s health has been neglected across science, medicine and technology. A new report from the World Economic Forum suggests tackling this could unlock a $1 trillion economic boost with the potential to change the lives of 3.9 billion women.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
