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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
NF-κB Factors Cooperate with Su(Hw)/E4F1 to Balance Drosophila/Human Immune Responses via Modulating Dynamic Expression of miR-210
[Nucleic Acids Research] Scientists confirmed that the conserved miRNA miR-210 negatively regulated innate immune responses of Drosophila and human via targeting Toll and TLR6, respectively.
A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease
[Circulation Research] Researchers utilized single-cell RNA-seq and single-cell multiomics approaches in primary human monocyte–derived macrophages to explore the transcriptional regulatory network involved in a critical pathogenic event of coronary atherosclerosis—the formation of lipid-laden foam cells.
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
[Translational Stroke Research] The authors summarize the structure and redox properties, secretion and pathways, regulation of immune cell activity, the role of pathophysiological mechanisms in stroke, and hemorrhage transformation for high-mobility group box 1 (HMGB1), which will pave the way for developing new neuroprotective drugs, reduction of post-stroke neuroinflammation, and expansion of thrombolysis time window.
Bispecific Antibody Takes a BiTE Out of B Cells in Rheumatoid Arthritis
[Nature] Amgen’s B-cell-depleting therapy blinatumomab (Blincyto) showed signs of efficacy in rheumatoid arthritis, found an academic-sponsored pilot trial of the CD19xCD3 bispecific T-cell engager (BiTE) in six patients with the autoimmune disease.
Valrubicin-Loaded Immunoliposomes for Specific Vesicle-Mediated Cell Death in the Treatment of Hematological Cancers
[Cell Death & Disease] Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, or acute myeloid leukemia in immunodeficient NSG mice, investigators generated patient-derived xenograft models, which were treated with valrubicin-loaded immunoliposomes loaded with antibodies to target CD19, CD7 or CD33.
HDAC Inhibition Increases CXCL12 Secretion to Recruit Natural Killer Cells in Peripheral T Cell Lymphoma
[Cancer Research] Researchers found that high expression of histone deacetylase (HDAC)3 was associated with poor prognosis in peripheral T cell lymphoma. HDAC3 inhibition suppressed lymphoma growth in immunocompetent mice but not in immunodeficient mice.
LGR6 Frameshift Variant Abrogates Receptor Expression on Select Leukocyte Subsets and Associates With Viral Infections
[Blood] In neutrophils, monocytes, and natural killer cells from volunteers homozygous for this variant, investigators found a significant downregulation in the expression of leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) when compared with controls without the variant.
Fate Therapeutics Announces First Lupus Patient Treated in Phase 1 Autoimmunity Study of Off-the-shelf FT819 CAR T-cell Program
[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the first patient with systemic lupus erythematosus has been treated in the Phase I autoimmunity study of FT819, the company’s off-the-shelf, CD19-targeted chimeric antigen receptor T cell program.
THEMIS Promotes T Cell Development and Maintenance by Rising the Signaling Threshold of the Inhibitory Receptor BTLA
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators showed that the T cell lineage protein THEMIS operates as a rheostat which restrain the signaling capacity the inhibitory receptor B- and T-lymphocyte attenuator (BTLA).
Triune Nanomodulator Enables Exhausted Cytotoxic T Lymphocyte Rejuvenation for Cancer Epigenetic Immunotherapy
[ACS Nano] Scientists presented a well-designed triune nanomodulator, termed ROCA, which demonstrated robust capabilities in tumor epigenetic modulation and immune microenvironment reprogramming for cancer epigenetic immunotherapy.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, researchers identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
The Immunoglobulin Superfamily Ligand B7H6 Subjects T Cell Responses to NK Cell Surveillance
[Science Immunology] By screening for mediators of natural killer (NK) cell recognition on T cells, investigators identified the immunoglobulin superfamily ligand B7H6 to be highly expressed by activated T cells, including patient-infused CD19-targeting chimeric antigen receptor (CAR) T cells.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
