Intestinal Cell News

Intestinal Cell News is an online resource that curates the latest research using intestinal cells.

A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors

June 14, 2024

[Clinical Cancer Research] Investigators tested the efficacy of a novel non-tyrosine kinase inhibitors compound, OPB-171775, using patient-derived xenograft models of gastrointestinal stromal tumor.

Repurposing FDA-Approved Compounds to Target JAK2 for Colon Cancer Treatment

June 14, 2024

[Discover Oncology] Researchers identified novel inhibitors for janus kinase 2 (JAK2) protein by performing virtual screening against FDA-approved compounds. Their results indicated that ergotamine, entrectinib, exatecan, dihydroergotamine, and paritaprevir could be used as alternative drugs for colon cancer.

Arcus Biosciences Completes Patient Enrollment in Phase III Trial Evaluating a Domvanalimab-Containing Regimen in First-Line Metastatic Upper GI Cancers

June 14, 2024

Arcus Biosciences, Inc. announced the completion of patient enrollment for STAR-221, a Phase III study in collaboration with Gilead Sciences, evaluating the combination of...

Bioengineered Human Colon Organoids with In Vivo-Like Cellular Complexity and Function

June 13, 2024

[Cell Stem Cell] Researchers integrated organoid and organ-on-a-chip technology to develop an advanced human organoid model, called “mini-colons.” By employing an asymmetric stimulation with growth factors, they greatly enhanced tissue longevity and replicated in vivo-like diversity and patterning of proliferative and differentiated cell types.

NFκB Signaling in Colorectal Cancer: Examining the Central Dogma of IKKα and IKKβ Signaling.

June 13, 2024

[Heliyon] The authors review the multiple components of NFκB signaling, highlighting that NFκB inducing kinase may be the central kinase for non-canonical NFκB signaling, and that IKKα is involved in novel pathways which promote colorectal cancer.

UNF Faculty Receive Patent for Discovering Cancer-Fighting Compound That Could ‘Turn Off’ Cancer

June 12, 2024

[University of North Florida] Three University of North Florida (UNF) researchers have been awarded a US patent for a targeted cancer-fighting compound, or peptoid, that the team has discovered targets certain breast, colon and lung cancers and stops them from progressing. This promising discovery could lead to significantly better patient outcomes for difficult to treat cancers.

Genetically Programmable Cell Membrane-Camouflaged Nanoparticles for Targeted Combination Therapy of Colorectal Cancer

June 12, 2024

[Signal Transduction and Targeted Therapy] Scientists introduced a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM nanoparticles (NPs). Notably, blocking CD47 with MPB-3BP@CM NPs enhanced the phagocytosis of colorectal cancer cells by macrophages.

Development of an Evaluation System Using Intestinal Organoids for Drug Efflux Transport Analysis by an Imaging Approach

June 12, 2024

[Journal of Pharmaceutical Sciences] Researchers investigated the effects of passage and cryopreservation of enteroids, organoids derived from intestine. They focused on P-glycoprotein (p-gp) and compared the transfer rates of rhodamine 123 into the lumen of enteroids with and without a P-gp inhibitor.

Human Gastric Cancer Progression and Stabilization of ATG2B through RNF5 Binding Facilitated by Autophagy-Associated CircDHX8

June 12, 2024

[Cell Death & Disease] Researchers investigated the mechanism underlying the role of hsa_circ_003899 (circDHX8) in the malignancy of gastric cancer (GC). CircDHX8 was identified as upregulated and shown to enhance the malignant progression in GC cells by promoting cellular autophagy.

Divergent Responses of Human Intestinal Organoid Monolayers Using Commercial In Vitro Cytotoxicity Assays

June 11, 2024

[PLOS One] Given the complexity of organoid cultures, including donor-driven variability, the authors investigated drug-treated, tissue stem cell-derived human intestinal organoid responses with commonly used cell cytotoxicity assay kits.

Tumor Cell-Derived Serglycin Promotes IL-8 Secretion of CAFs in Gastric Cancer

June 11, 2024

[British Journal of Cancer] Scientists revealed the mechanisms of the preferential production of IL-8 by cancer-associated fibroblasts (CAFs) in gastric cancer. Serglycin secreted by tumour cells activated the CD44/c-Myc pathway to upregulate lysine[K]-specific demethylase 5B expression, thereby promoting IL-8 production in CAFs.

Patient-Derived Organoid Biobank Identifies Epigenetic Dysregulation of Intestinal Epithelial MHC-I as a Novel Mechanism in Severe Crohn’s Disease

June 11, 2024

[Gut] Using intestinal epithelial organoids generated from mucosal biopsies, scientists investigated the role of intestinal epithelial DNA methylation in Crohn’s disease pathogenesis.

Since 2015, Intestinal Cell News has been a valuable resource for keeping researchers and medical professionals updated on the latest publications, news and events in the field of gastrointestinal cell biology. Our editorial team collects and publishes the most current articles and reviews using stomach, colon, and small and large intestinal cells. We cover topics including the culturing of intestinal cells, intestinal organoids, intestinal cancers, and gastrointestinal conditions such as irritable bowel syndrome and Crohn’s disease.