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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Vasculogenic Precedes Neurogenic Differentiation in Dental Pulp Stem Cells
[Journal of Dental Research] Researchers induced vasculogenic, odontoblastic, or neurogenic differentiation of human dental pulp stem cells for 7 days in vitro and performed single-cell RNA sequencing.
Late Embryogenesis Abundant Protein 3-Modified Human Umbilical Cord Mesenchymal Stem Cell Sheet Exhibits Antifreeze Properties
[International Journal of Biological Macromolecules] Investigators demonstrated that the late embryogenesis abundant proteins-modified human umbilical cord MSCs sheet exhibits antifreeze properties, which provides a technological basis for the establishment of a cell sheet storage bank.
Shear Stress-Mediated Downregulation of Mir-423-5p in M2 Macrophage Exosomes Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
[International Immunopharmacology] Scientists explored the regulatory mechanism of miR-423-5p in M2 macrophage exosomes on the osteogenic differentiation of bone marrow MSCs under a mechanical microenvironment, providing a theoretical basis for cell-free fracture repair therapy.
FKBP5 Regulates Osteogenesis of Human iPSC-Derived Mesenchymal Stem Cells via FKBP5-AKT-FOXO1 Pathway
[Journal of Cellular and Molecular Medicine] Investigators revealed that FKBP5 promotes the osteogenic differentiation of induced pluripotent stem cell-derived MSCs (iMSCs) partially through the FKBP5-AKT-FOXO1 pathway, presenting a promising approach to iMSC transplantation for clinical bone defects.
Naringenin Restores Osteogenic Differentiation in TNF-α-Treated Bone Marrow Mesenchymal Stem Cells by Targeting AKR1B1
[Scientific Reports] In vitro experiments demonstrated that naringenin restored osteogenic capacity in TNF-α-treated human bone marrow MSCs, enhancing ALP activity, mineralization, and expression of RUNX2/OCN while reducing IL-6/IL-1β levels.
Chemical Direct Conversion of Human Fibroblasts to Mesenchymal Stem Cells That Can Alleviate Inflammation In Vivo
[Stem Cell Research & Therapy] The authors converted human dermal fibroblasts into MSC-like cells with high anti-inflammatory activities using a combination of a TGF-β receptor inhibitor, a ROCK inhibitor, and an ATM inhibitor.
Intra-Articular Delivery of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells (BM-MSCs) for Painful Lumbar Facet Arthropathy: A Phase I Clinical Trial
[Stem Cell Research & Therapy] Researchers evaluated the safety and preliminary efficacy of intra-articular delivery of allogeneic bone marrow-MSCs in patients with painful lumbar facet arthropathy.
Mesenchymal Stem Cell Derived Extracellular Vesicles Reverses Neural Aging via OSKM Modulation
[Cell Communication and Signaling] Scientists represented a pioneering achievement in regenerative medicine, demonstrating the potential of microRNAs in extracellular vesicles to stimulate OSKM, a significant stride forward in addressing neural aging.
Quercetin-Loaded Mesenchymal Stem Cell Derived Extracellular Vesicles Enhance Ovarian Function in a Cyclophosphamide Induced Ovarian Damage
[Journal of Ovarian Research] Researchers investigated whether intraovarian administration of quercetin-loaded extracellular vesicles derived from Wharton’s jelly MSCs improves ovarian function in a cyclophosphamide-induced premature ovarian insufficiency rat model.
Functionalized Mesenchymal Stem Cells for Enhanced Bone Regeneration: Advances and Challenges
[Stem Cell Research & Therapy] The authors explore recent developments in the functionalization of stem cells to increase their bone-forming potential. They cover techniques of gene modification, preconditioning, nanoparticle integration, and scaffold-based delivery.
BOOST Pharma Adds Sound Bioventures to Investor Syndicate with SEK 34 Million Investment to Advance Stem Cell Therapy for Osteogenesis Imperfecta
[BOOST Pharma ApS (Globe Newswire)] BOOST Pharma ApS announced that Sound Bioventures has joined its investor syndicate with a SEK 34 million investment. The financing will support continued clinical development of BT-101, a stem cell-based therapy for osteogenesis imperfecta.
Recent Advances in CAR-MSCs: The New Engine of Cellular Immunotherapy Evolution
[Journal of Hematology & Oncology] The authors examine the engineering design, biological characteristics, and applications of chimeric antigen receptor-MSCs in oncology and immune-related disorder therapy.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
