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Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Mesenchymal Stromal Cells Engineered with ACE2 for Treatment of Receptor-Mediated Viral Lung Injury
[Molecular Therapy] Scientists engineered MSCs expressoing human ACE2, designed to couple direct antiviral activity with immonoregulation.
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
[Cancer Research] Upon expression of EWSR1::FLI1 in human pediatric mesenchymal stem cells, considered the putative cell of origin of Ewing sarcoma, scientists unraveled the genome-wide redistribution of H3K27me3.
Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling
[FASEB Journal] D-galactose–induced premature MSCs were preconditioned with cyclic stretch. The expression levels of CXCR4, senescence markers, and osteogenic markers were assessed and compared with those in young and naturally aged MSCs.
Human Mesenchymal Stem Cell Derived Exosomes Endowed with Mir-13474 As a Therapeutic Delivery Vehicle for Diabetic Wound Healing by Targeting the CPEB2/TWIST1 Axis
[ACS Applied Bio Materials] Scientists revealed the role of human MSC-derived exosomes and the underlying molecular mechanism in diabetic wound healing and proposed a cell-free-based modification strategy for refractory wound management.
Cell-Derived Vesicles Extruded from Adipose Mesenchymal Stem Cells Attenuate Intestinal Inflammation and Augment Epithelial Regeneration in a Colitis Model
[Nanoscale] Investigators analyzed the characteristics and therapeutic effects of adipose-derived stem cell (ADSC)-derived vesicles compared to ADSCs and ADSC extracellular vesicles through ex vivo organoid and in vivo colitis experiments.
UCMSCs-Derived Exosomal circHIPK3 Restrains Oxidative Stress and Inflammation by Downregulating the Stability of HMGB1 mRNA via Recruiting UPF1 in Diabetes Foot Ulcer
[FASEB Journal] The authors elucidated the downstream mechanisms through which umbilical cord MSCs-derived exosomal circHIPK3 modulates oxidative stress and inflammation in cellular and mice models of diabetic foot ulcers.
A Three-Dimensional Microporous Decalcified Bone Matrix Combined with Bone Marrow Mesenchymal Stem Cells Enhances Bone Regeneration in Critical-Sized Calvarial Defect of Nude Mouse
[ACS Applied Bio Materials] Researchers investigated a three-dimensional microporous demineralized bone matrix combined with bone marrow MSCs to enhance the outcomes of bone defect repair.
Therapeutic Potentials of Mesenchymal Stem Cells and Their Extracellular Vesicles on Liver Diseases by Modulating Mitochondrial Function of Macrophages
[International Immunopharmacology] The authors summarize the multiple types of mitochondrial damage in macrophages across various liver diseases and comprehensively discuss how MSCs can modulate macrophage mitochondrial function, including mitochondrial biogenesis and dynamics, mitophagy, and metabolic remodeling, or directly donate healthy mitochondria to alleviate liver diseases.
Longeveron Granted US Patent for Method of Treating Aging-related Frailty in Patients with Inflammaging Using its Proprietary Stem Cell Therapy
[Longeveron, Inc.] Longeveron, Inc. announced that the United States Patent and Trademark Office has granted a patent covering administration of the company’s proprietary MSCs for the treatment of patients with symptoms of aging-related frailty.
Bone Marrow Mesenchymal Stromal Cell Osteogenesis Is Driven by Paracrine Signals from Regulatory T Cell
[Stem Cell Reviews and Reports] Researchers revealed that Treg-conditioned media enhances not only osteogenesis in vitro but also fosters a pro-regenerative microenvironment.
FZD6 Mediates the Contributing Role of Mir-199a-5p in the Adipogenesis of Bone Marrow Mesenchymal Stem Cells Derived from Aplastic Anemia
[Scientific Reports] Scientists further characterized the contributing role of miR-199a-5p in adipogenesis of aplastic anemia bone marrow-MSCs through specific inhibition of miR-199a-5p expression.
Investigations into the Basal Neural-Like Properties of Dental Pulp Stem Cells Reveal They Possess a Functional Type 2 Muscarinic Receptor Which Regulates Quiescence
[Stem Cell Research & Therapy] Analysis of the neurotransmitter profile of dental pulp stem cells revealed they have cholinoceptive properties and pharmacological investigations confirmed they express a functional type 2 muscarinic receptor.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
