 | | Vol. 17.16 – 27 April, 2022 |
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| The authors showed that suitable combinations of mechanical stimuli and metabolic cues could enhance the maturation of human iPSC-derived cardiomyocytes, and that the maturation-inducing cues had phenotype-dependent effects on the cells’ action-potential morphology and calcium handling.
[Nature Biomedical Engineering] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established a lung and macrophage co-culture system derived from hPSCs, modeling the host-pathogen interaction in SARS-CoV-2 infection.
[Nature Communications] |
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| Investigators dissected the landscape of histone modifications and regulatory map of LTRs by integrating 98 ChIP-seq data in human ESCs, and annotated the active LTRs enriching enhancer/promoter-related histone marks.
[Nucleic Acids Research] |
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| Scientists showed that in mouse ESCs, argonaute 1&2 served additional functions that go beyond the miRNA pathway.
[Stem Cell Reports] |
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| By mimicking in vivo microglial development, researchers established a simplified approach to differentiate hPSCs into high purity brain-induced microglia-like cells.
[Science China Life Sciences] |
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| The authors generated a human iPSC line JUCTCi019-A using dermal fibroblasts-derived from a 50-year-old CMT2A2 patient carrying a heterozygous missense substitution c.2119C > T in the MFN2 gene.
[Stem Cell Research] |
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| The iPSC line showed pluripotency which was confirmed by immunofluorescent staining; the iPSC line was also able to form embryoid bodies in vitro and differentiate into the three germ layers in vivo.
[Stem Cell Research] |
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| Combining miRNA sequencing data with publicly archived miRNA microarray datasets, investigators demonstrated that miRNAs belonging to the 300 family and 500 family were highly expressed in iPSCs compared with a number of differentiated cell types.
[Cytotherapy] |
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| The authors found that the PDMS substrate coated with a combination of polydopamine and laminin-511 E8 fragments coud support hiPSC attachment and growth for the long term and satisfy their demands of differentiation into cardiomyocytes.
[ACS Biomaterials Science & Engineering] |
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| Investigators presented a method that could estimate RNA synthesis, processing and degradation rates from a single sample. It relied on the analytical solution to the Zeisel model of RNA dynamics.
[BMC Bioinformatics] |
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| Researchers investigated the role of pyruvate kinase muscle isoforms (PKM1/2) in naïve, formative, and primed mouse ESCs through modulation of PKM1/2 mRNA transcripts using steric blocking morpholinos that downregulate PKM2 and upregulate PKM1.
[Stem Cells and Development] |
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| Investigators focus on the key processes and guidelines for clinical translation of hPSC-derived β cells for diabetes cell therapy.
[Cell Proliferation] |
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| Scientists conceptualize the advances in understanding the disease polygenicity and convergence from the past decade of iPSC modeling of different types of genetic risk factors of neuropsychiatric disorders.
[Schizophrenia Research] |
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| NexImmune, Inc. announced a preclinical research collaboration with Columbia University Irving Medical Center’s Herbert Irving Comprehensive Cancer Center. The research will focus on the use of NexImmune’s adoptive cell therapy, AIM ACT, in Columbia’s patient-derived organoid models of HPV-associated cancers.
[NexImmune, Inc.] |
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| With the new award, Institute for the Biology of Stem Cells directors Camilla Forsberg and Lindsay Hinck have now brought in nearly $12 million to fund the future of bimolecular research at UC Santa Cruz.
[UC Santa Cruz] |
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| June 26 – July 1, 2022
Waterville Valley, New Hampshire, United States |
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| | New York University College of Dentistry – New York, New York, United States |
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| | UK Dementia Research Institute – London, England, United Kingdom |
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| | University of Singapore – Singapore, Singapore |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | University of Gothenburg – Gothenburg, Sweden |
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