Hematopoiesis News Volume 13.22 | Jun 07 2022

June 7, 2022

2021-06-07 | HN 13.22

Hematopoiesis
News by STEMCELL Technologies

Vol. 3.22 – 7 June, 2022

TOP
STORY

Clonal
Dynamics of Hematopoiesis Across the Human Lifespan

Scientists sequenced whole genomes of 3,579 single cell-derived hematopoietic colonies from ten healthy individuals
spanning the human lifespan, revealing an abrupt and universal loss of clonal diversity after the age of 70 years.
[Nature]

Full Article

Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

PLAG1 Dampens Protein Synthesis to Promote Human
Hematopoietic Stem Cell Self-Renewal

The authors demonstrated that the transcription factor PLAG1 was essential for long-term HSC function and when
overexpressed endowed a 15.6-fold enhancement in the frequency of functional HSC in stimulatory conditions.
[Blood]

Full Article

Integrative
Epigenomic and Transcriptomic Analysis Reveals the Requirement of JUNB for Hematopoietic Fate Induction

Scientists systematically profiled the chromatin accessibility, H3K4me3 and H3K27me3 modifications, and the
transcriptome of intermediate progenitors during hematopoietic progenitor cell differentiation in vitro.
[Nature Communications]

Full Article

Upregulation of
NKG2D Ligands Impairs Hematopoietic Stem Cell Function in Fanconi Anemia

Researchers demonstrated the involvement of NKG2D/Natural Killer group 2 member D ligands (NKG2D-L) interactions in
Fanconi Anemia (FA) HSPC functionality, suggesting an unexpected role of the immune system in the progressive bone marrow failure characteristic of FA.
[Journal of Clinical Investigation]

Full Article

Ionophore-Mediated
Swelling of Erythrocytes as a Therapeutic Mechanism in Sickle Cell Disease

The authors treated 13 blood samples from patients with sickle cell disease with 10 nM of monensin ex
vivo.
[Haematologica]

Full Article

Extramedullary
Hematopoiesis: Mesenchymal Stromal Cells From Spleen Provide an In Vitro niche for myelopoiesis

Researchers showed that splenic stroma of both human and murine origin provided a mesenchymal stromal cell
microenvironment which was WNT pathway–dependent, and supported in vitro myelopoiesis with production of specific subsets of myeloid and dendritic-like cells.
[Animal]

Full Article

CLINICAL RESEARCH

Prophylactic Tranexamic Acid in Patients with Hematologic
Malignancy: A Placebo Controlled, Randomized Clinical Trial

To determine whether tranexamic acid safely reduced bleeding incidence in patients undergoing treatment for
hematologic malignancies, a randomized double blind clinical trial was conducted.
[Blood]

Full Article

STR
Typing of Skin Swabs from Individuals After an Allogeneic Hematopoietic Stem Cell Transplantation

Swabs from different skin areas were collected from 28 transplanted patients in this study. STR profiles were
created and used to determine the proportion of recipient to donor alleles.
[International Journal of Legal Medicine]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

PPM1D in Solid and Hematologic Malignancies:
Friend and Foe?

Scientists examined the mechanisms through which Protein Phosphatase Mg²⁺/Mn²⁺-Dependent 1D
overexpression or mutation might have driven malignancy by suppression of DNA repair, cell cycle arrest, and apoptosis.
[Molecular Cancer Research]

Abstract

INDUSTRY AND POLICY
NEWS

Novartis Scemblix^®, with Novel Mechanism of
Action, Shows Superior, Long-Term Efficacy and Consistent Tolerability in 96-Week Follow-Up of Chronic Myeloid Leukemia Trial

Novartis announced longer-term follow-up data from the Phase III ASCEMBL trial for patients with Philadelphia
chromosome-positive chronic myeloid leukemia in chronic phase previously treated with two or more tyrosine kinase inhibitors.
[Novartis, Inc.]

Press Release

FEATURED EVENT

Hematopoiesis News Volume 13.22 | Jun 07 2022

Clonal
Dynamics of Hematopoiesis Across the Human Lifespan

PLAG1 Dampens Protein Synthesis to Promote Human
Hematopoietic Stem Cell Self-Renewal

Integrative
Epigenomic and Transcriptomic Analysis Reveals the Requirement of JUNB for Hematopoietic Fate Induction

Upregulation of
NKG2D Ligands Impairs Hematopoietic Stem Cell Function in Fanconi Anemia

Ionophore-Mediated
Swelling of Erythrocytes as a Therapeutic Mechanism in Sickle Cell Disease

Extramedullary
Hematopoiesis: Mesenchymal Stromal Cells From Spleen Provide an In Vitro niche for myelopoiesis

Prophylactic Tranexamic Acid in Patients with Hematologic
Malignancy: A Placebo Controlled, Randomized Clinical Trial

STR
Typing of Skin Swabs from Individuals After an Allogeneic Hematopoietic Stem Cell Transplantation

PPM1D in Solid and Hematologic Malignancies:
Friend and Foe?

Novartis Scemblix^®, with Novel Mechanism of
Action, Shows Superior, Long-Term Efficacy and Consistent Tolerability in 96-Week Follow-Up of Chronic Myeloid Leukemia Trial

Gene Therapy Development & Manufacturing

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Postdoctoral Training Fellow – Applied
Biotechnology

Scientist/Lead Researcher – Cell Therapy for
Leukemias

Postdoctoral Fellow – Microenvironment and Signaling

Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism

Post-Doctoral Fellow – Translational Immunology in Cell
Therapies

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