 | | Vol. 6.37 – 14 October, 2022 |
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| Scientists used human liver organoids in experimental systems to mimic the early stages of human liver carcinogenesis from the genetic lesions of TP53 loss and L3 loop R249S mutation.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Lrat+Fbln2+ cells had 3-15x inductions of profibrotic, myofibroblastic, and immunoregulatory genes vs. Lrat+Fbln2– cells, but 2-4x repressed hepatic stellate cell-selective genes.
[Hepatology] |
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| Low BNIP3 expression in human HCC correlated with increased lipid content and worse prognosis than HCC expressing high BNIP3. BNIP3 suppressed HCC cell growth by promoting lipid droplet turnover at the lysosome in a manner dependent on BNIP3 binding LC3.
[Science Advances] |
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| Researchers demonstrated the possible association between upregulation of TrkC and acquisition of cancer stem cells traits or chemoresistance in HCC. They showed that upregulation of TrkC was closely associated with the survival and progression of HCC in vivo and in vitro.
[Cell Death & Disease] |
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| Investigators validated significant overexpression of PLA2G2A across in situ gallbladder carcinoma (GBC) cells, together with increased proliferation and cancer stemness in PLA2G2A-overexpressing GBC cells, indicating an important role for PLA2G2A during early carcinogenesis.
[Cell Discovery] |
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| HepG2 cells were administered with three different concentrations of folic acid for 10 days. Fluorescence-activated cell sorting was done to evaluate cell viability and apoptosis. Agarose-coated plates were used to access cancer stem cells number.
[Scientific Reports] |
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| Scientists demonstrated that in hepatic fibrosis, TGF-β stimulated the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells, which facilitated the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner.
[Nature Metabolism] |
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| The authors discuss molecular mechanisms and signaling pathways involved in ferroptosis and offer their opinions on druggable targets and new therapeutic strategy in an attempt to restrain the growth and progression of hepatocellular carcinoma through induction of ferroptotic cell death.
[British Journal of Cancer] |
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| Investigators review the history of the development of liver organoids and summarize the application of liver organoids and recent studies using organoids to explore and further repair the liver injury.
[Stem Cell Reviews and Reports] |
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| Kezar Life Sciences, Inc. announced that it received clearance of its Investigational New Drug (IND) application from the US FDA for zetomipzomib, its first-in-class, selective immunoproteasome inhibitor, for the treatment of autoimmune hepatitis.
[Kezar Life Sciences, Inc.] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | STEMCELL Technologies – Vancouver, British Columbia, Canada |
| | | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | University of California San Francisco – San Francisco, California, United States |
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