 | | Vol. 8.31 – 26 August, 2022 |
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| Scientists optimized human small intestinal organoid culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using intravital imaging, researchers observed that villus group 3 innate lymphoid cells were largely immotile at steady state but acquired migratory ‘patrolling’ attributes and enhanced cytokine expression in response to inflammation.
[Nature Immunology] |
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| Hematopoietically expressed homeobox (HHEX) was required for the pro-tumorigenic effects of yes-associated protein (YAP) during colorectal cancer progression. In response to serum stimulation, Casein Kinase 2 (CK2) phosphorylated HHEX and enhanced its interaction with TEAD4.
[Nature Communications] |
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| Scientists found that expression of the hominid-restricted retrogene POU5F1B through aberrant activation of a primate-specific endogenous retroviral promoter was a strong negative prognostic biomarker and demonstrated that POU5F1B fostered the proliferation and metastatic potential of colorectal cancer cells.
[Nature Communications] |
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| The authors demonstrated that centrosomal protein 63 (CEP63) protein was upregulated in a large cohort of colorectal cancer tissues and predicted poor prognosis, and USP36 was identified for stabilizing CEP63 by enhancing its K48-dependent deubiquitination.
[Oncogene] |
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| Metastasis-associated in colorectal cancer-1 (MACC1) strengthened the interaction of β-catenin with TCF4, thus inducing S100A4 synthesis transcriptionally, resulting in elevated secretion to enforce cell motility and metastasis.
[Oncogene] |
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| Investigators produced a stem cell factor (SCF)-emtansine drug conjugate with favorable drug efficacy towards gastrointestinal stromal tumor cells and evaluated it using in vitro cell-based assays and an in vivo xenograft mouse model.
[BMC Medicine] |
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| The absence of CDK5RAP3 in gastric cancer cells allowed macrophages to secrete more matrix metalloproteinase 2 to promote the epithelial-mesenchymal transition process of gastric cancer cells, thereby enhancing the invasion and migration ability.
[Cancer Gene Therapy] |
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| A proteomic screen was performed to reveal altered protein kinase phosphorylation in oxaliplatin-resistant colorectal cancer (CRC) tumor spheroids. The function of CHK2 was characterised using several biochemical techniques and evident using in vitro cell and in vivo tumor models.
[British Journal of Cancer] |
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| Scientists established, characterized, and validated 3D cultures of intestinal organoids obtained from biopsies of NF-κB-RE-Luc mice.
[Scientific Reports] |
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| Recent experimental studies have shown that fructose not only serves as a substrate for, among others, intrahepatic lipid formation, but also has a signaling function.
[Trends in Endocrinology and Metabolism] |
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| Anthos Therapeutics announced the initiation of recruitment for its second Phase III clinical trial investigating abelacimab, its novel dual-acting fully human monoclonal antibody targeting both Factor XI and Factor XIa.
[Anthos Therapeutics] |
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| November 2 – 4, 2022
Lyon, France |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | University of California Santa Cruz – Santa Cruz, California, United States |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Duke University – Durham, North Carolina, United States |
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