Pulmonary Cell News Volume 11.22 | Jun 9 2022

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    Danielle Corrigan
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    2022-06-09 | PULCN 11.22


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.22 – 9 June, 2022
    TOP STORY

    Recapitulated Crosstalk Between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip

    A novel 3D microfluidic tri-culture platform was proposed for recapitulating positive feedback from brain metastatic NSCLC astrocytes and brain-specific endothelial cells, two major players in the brain tumor microenvironment.
    [Advanced Science]

    Full Article

    How to prioritize and manage your research projects
    PUBLICATIONSRanked by the impact factor of the journal

    DNA Methylation Signatures in Airway Cells From Adult Children of Asthmatic Mothers Reflect Subtypes of Severe Asthma

    Scientists performed differential DNA methylation analyses of 398,186 individual CpG sites in primary bronchial epithelial cells from 42 nonasthma controls and 88 asthma cases, including 56 without maternal asthma (MA) and 32 with MA.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Loss of Core-Fucosylation of SPARC Impairs Collagen Binding and Contributes to COPD

    Silencing of α1,6-fucosyltransferase, the enzyme for core-fucosylation and highly expressed in lung stem cells, resulted in alveolar structural changes in lung organoids, recapitulating COPD.
    [Cellular and Molecular Life Sciences]

    Full Article

    Systematic Analyses Identify the Anti-Fibrotic Role of lncRNA TP53TG1 in IPF

    The authors systematically identified a crucial lncRNA, p53-induced long non-coding RNA TP53 target 1 (TP53TG1), which was the dysregulated hub gene in the idiopathic pulmonary fibrosis (IPF) regulatory network and one of the top degree genes down-regulated in IPF-derived fibroblasts.
    [Cell Death & Disease]

    Full Article

    Fibroblast Growth Factor-9 Expression in Airway Epithelial Cells Amplifies the Type I Interferon Response and Alters Influenza A Virus Pathogenesis

    Scientists demonstrated that fibroblast growth factor-9 signaling primed the conducting airway epithelium to rapidly induce a localized type I interferon and proinflammatory cytokine response during viral infection.
    [PLoS Pathogens]

    Full Article

    Electronic Cigarette Vapor Exposure Exaggerates the Pro-Inflammatory Response During Influenza A Viral Infection in Human Distal Airway Epithelium

    The authors investigated the effects of electronic cigarette vapor on human distal airway epithelial responses to influenza A virus infection. They isolated primary small airway epithelial cells from donor lungs free of lung disease, and cultured them at air–liquid interface.
    [Archives of Toxicology]

    Full Article

    Airway Epithelial STAT3 Inhibits Allergic Inflammation via Upregulation of Stearoyl-CoA Desaturase 1

    Recent studies have revealed that STAT3 expressed in epithelial cells protects against pathogens and maintains homeostasis in the intestine. Scientists elucidated the roles of airway epithelial STAT3 in allergic airway inflammation.
    [Allergology International]

    Full Article

    CircVAPA Promotes Small Cell Lung Cancer Progression by Modulating the miR-377-3p and miR-494-3p/IGF1R/AKT Axis

    The authors revealed that circVAPA, derived from exons 2-4 of the vesicle-associated membrane protein-associated protein A gene, exhibited higher expression levels in SCLC cell lines, clinical tissues, and serum from SCLC patients than the controls, and facilitated SCLC progression in vitro and in vivo.
    [Molecular Cancer]

    Full Article

    Image Analysis Reveals Molecularly Distinct Patterns of TILs in NSCLC Associated With Treatment Outcome

    The study of over 1000 lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumors demonstrated that computationally derived patterns of tumor-infiltrating lymphocytes (TILs) on H&E images were different between LUAD and LUSC.
    [npj Precision Oncology]

    Full Article

    Elevated circASCC3 Limits Antitumor Immunity by Sponging miR-432–5p To Upregulate C5a in Non-Small Cell Lung Cancer

    The functions and mechanisms of circASCC3 in NSCLC progression and anti-programmed cell death 1 resistance were uncovered in vitro and in vivo.
    [Cancer Letters]

    Abstract

    Cancer Stem Cells and Cell Cycle Genes As Independent Predictors of Relapse in Non-Small Cell Lung Cancer: Secondary Analysis of a Prospective Study

    Scientists investigated cancer stem cell frequency and recurrence-related genes expression as predictors of disease-free survival in lung cancer.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Nuclear p120 Catenin Is a Component of the Perichromosomal Layer and Coordinates Sister Chromatid Segregation During Mitosis in Lung Cancer Cells

    Abnormal expression of p120 catenin is associated with the malignant phenotype in human lung cancer. Researchers investigated the dynamic changes in nuclear p120 catenin localization during cell cycle progression.
    [Cell Death & Disease]

    Full Article

    Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression via the Wnt/β-Catenin Signaling Pathway in Lung Adenocarcinoma

    Investigators evaluated the role of junctional adhesion molecule-like protein in lung adenocarcinoma.
    [Journal of Translational Medicine]

    Full Article

    Explore tools and resources for your return to the lab
    REVIEWS

    What Can an Organ-on-a-Chip Teach Us about Human Lung Physiology?

    The authors discuss how organ-on-a-chip has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.
    [Physiology]

    Abstract

    Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

    Exploring the brain–lung axis not only helps us to understand the development of the disease from different aspects, but also provides an important target for treatment strategies.
    [Cellular and Molecular Neurobiology]

    Full Article

    INDUSTRY AND POLICY NEWS

    CStone and Pfizer Announce NMPA Approval of Sugemalimab in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

    CStone Pharmaceuticals and Pfizer, Inc. announced that the National Medical Products Administration (NMPA) of China has approved sugemalimab for the treatment of patients with unresectable stage III NSCLC.
    [CStone Pharmaceuticals]

    Press Release

    ORYZON announces FDA Orphan Drug Designation granted to iadademstat for treatment of Small Cell Lung Cancer

    Oryzon Genomics, S.A. announced that the US FDA has granted Orphan Drug Designation to the company’s clinical-stage LSD1 inhibitor iadademstat for the treatment of patients with SCLC.
    [Oryzon Genomics, S.A.]

    Press Release

    FEATURED EVENT

    Till & McCulloch Meetings

    October 3 – 5, 2022
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Tenure Track Assistant or Associate Professor – Lung Inflammation

    Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Candidate – Cancer Biology

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Fellow – Cancer Immunology & Genomics

    La Jolla Institute for Immunology – La Jolla, California, United States

    PhD Candidate – Cellular and Molecular Mechanisms of Cancer

    Norwegian University of Science and Technology -Trondheim, Norway

    Postdoctoral Fellow – Tumor Microenvironment in Metastasis

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

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