Umbilical & Placental Cell News Volume 14.40 | Oct 13 2022

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    2022-10-13 | UPCN 14.40


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    Vol. 14.40 – 13 October, 2022
    TOP STORY

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miR-655-3p Inhibit the Development of Esophageal Cancer by Regulating the Expression of HIF-1α via a LMO4/HDAC2-Dependent Mechanism

    Researchers clarified the function of human umbilical cord MSC-derived extracellular vesicle-enclosed miR-655-3p in esophageal squamous cell carcinoma.
    [Cell Biology and Toxicology]

    Abstract
    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    PUBLICATIONSRanked by the impact factor of the journal

    Exosomal Thioredoxin-1 from Hypoxic Human Umbilical Cord Mesenchymal Stem Cells Inhibits Ferroptosis in Doxorubicin-Induced Cardiotoxicity via mTORC1 Signaling

    The authors compared the therapeutic effects between normoxic human umbilical cord (Huc) MSCs-derived exosomes (Exo) and hypoxic HucMSCs-Exo on doxorubicin-induced ferroptosis and explored the underlying mechanisms.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract

    Lipopolysaccharide Induces Placental Mitochondrial Dysfunction in Murine and Human Systems by Reducing MNRR1 Levels via a TLR4-Independent Pathway

    In a lipopolysaccharide-induced model of systemic placental inflammation, scientists showed that mitochondrial nuclear retrograde regulator 1 (MNRR1) levels were reduced both in mouse placental tissues in vivo and in human trophoblastic cell lines in vitro.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Placental Mesenchymal Stem Cells Restore Glucose and Energy Homeostasis in Obesogenic Adipocytes

    Researchers assessed the beneficial effects of human placental MSCs in mitigating obesity-associated insulin resistance and mitochondrial dysfunction both in vivo and in vitro.
    [Cell and Tissue Research]

    Abstract

    Activation of the Kynurenine–Aryl Hydrocarbon Receptor Axis Impairs the Chondrogenic and Chondroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stromal Cells in Osteoarthritis Rats

    The effects of kynurenine, one of the most important metabolites of tryptophan, were evaluated on the chondrogenic and chondroprotective effects of human umbilical cord-derived MSCs.
    [Human Cell]

    Abstract

    Improved Survival after Single-Unit Cord Blood Transplantation Using Fludarabine and Melphalan-Based Reduced-Intensity Conditioning for Malignant Lymphoma: Impact of Melphalan Dose and Graft-versus-Host Disease Prophylaxis with Mycophenolate Mofetil

    Investigators evaluated 413 adult patients with lymphoma who underwent unrelated cord blood transplantation with fludarabine and melphalan-based reduced-intensity conditioning.
    [Annals of Hematology]

    Abstract
    Listen to the Stem Cell Podcast episodes covering ISSCR 2022 sessions.
    REVIEWS

    Applications of Acellular Human Amniotic Membrane in Regenerative Medicine

    Scientists discuss recent applications of human amniotic membrane in skin transplantation and wound healing, ophthalmology, orthopedics, cell culture matrix, cell delivery system, cardiac injury, male and female reproductive systems, and the liver.
    [Life Sciences]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Americord® Releases Exosomes Banking with CryoMaxx™ Processing

    Americord Registry® announced the addition of exosome banking to their suite of family-focused services, becoming the first private biobanking company in the United States to do so.
    [Americord Registry® (EIN Presswire)]

    Press Release
    FEATURED EVENT

    Frontiers in Cancer Science 2022

    November 7 – 9, 2022
    Singapore, Singapore

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    JOB OPPORTUNITIES

    Postdoctoral Scholar – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    Assistant/Associate Faculty Position – Cancer Research

    University of Colorado Denver – Aurora, Colorado, United States

    Postdoctoral Associate – Hematopoietic Stem Cells

    Baylor College of Medicine – Houston, Texas, United States

    Research Professor – Tissue Regeneration Engineering

    Institute of Tissue Regeneration Engineering – Cheonan, South Korea

    Faculty Position – Molecular Biology of Reproduction

    UT Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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