CKS1 Inhibition Depletes Leukemic Stem Cells and Protects Healthy Hematopoietic Stem Cells in Acute Myeloid Leukemia

Researchers studied the role of cyclin-dependent kinase regulatory subunit 1 (CKS1)–dependent protein degradation in primary human acute myeloid leukemia and healthy hematopoiesis xenograft models in vivo.