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e.g. organoids

Splenic Red Pulp Macrophages Provide a Niche for CML Stem Cells and Induce Therapy Resistance

Investigators demonstrated that leukemia stem cells preferentially accumulated in the spleen and contribute to disease progression.
[Leukemia]
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Therapeutic Blockade of ER Stress and Inflammation Prevents NASH and Progression to HCC

[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
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Direct Mechanical Exposure Initiates Hepatocyte Proliferation

[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
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Cholangiocarcinoma-on-a-Chip: A Human 3D Platform for Personalized Medicine

[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.
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