Genotype-Phenotype Mapping of a Patient-Derived Lung Cancer Organoid Biobank Identifies NKX2-1-Defined Wnt Dependency in Lung Adenocarcinoma

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To build a preclinical platform that covered the broad disease spectrum of human lung cancer, the authors obtained lung cancer specimens from multiple sources, including sputum and circulating tumor cells, and generated a living biobank consisting of 43 lines of patient-derived lung cancer organoids.
[Cell Reports]
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