Abemaciclib Drives the Therapeutic Differentiation of Acute Myeloid Leukemia Stem Cells

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To screen drugs to overcome differentiation blockade for acute myeloid leukemia, researchers conducted screening of 2040 small molecules from a library of US FDA-approved drugs and found that the cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerted high anti-leukemic activity.
[British Journal Of Haematology]
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