Enhancing HIV-1 Latency Reversal through Regulating the Elongating RNA Pol II Pause-Release by a Small-Molecule Disruptor of PAF1C

[Journal Of Clinical Investigation] Researchers showed that RB1-loss/E2F activation sensitized cancer cells to ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, by upregulating expression of ACSL4 and enriching ACSL4-dependent arachidonic acid-containing phospholipids, which are key components of ferroptosis execution.

[Clinical Cancer Research] Scientists observed that Trop-2 can serve as a cell surface target for isolating circulating tumor cells, which may serve as a predictive biomarker for antibody drug conjugates.

[Journal Of Experimental & Clinical Cancer Research] Investigators reported the development of a novel CD46-targeted alpha therapy based on the internalizing human monoclonal antibody, YS5.