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e.g. organoids

Synthetic Enforcement of STING Signaling in Cancer Cells Appropriates the Immune Microenvironment for Checkpoint Inhibitor Therapy

Scientists found in human and murine colorectal cancer (CRC) models that the superior antitumor immune response of mismatch repair–deficient CRC required tumor cell–intrinsic activation of cGAS-STING signaling triggered by genomic instability.
[Science Advances]
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