Synthetic Enforcement of STING Signaling in Cancer Cells Appropriates the Immune Microenvironment for Checkpoint Inhibitor Therapy

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Scientists found in human and murine colorectal cancer (CRC) models that the superior antitumor immune response of mismatch repair–deficient CRC required tumor cell–intrinsic activation of cGAS-STING signaling triggered by genomic instability.
[Science Advances]
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