Genetics and Epigenetics of Primary Sjögren Syndrome: Implications for Future Therapies
The authors discuss the genetic and epigenetic features that have been robustly connected with primary Sjögren syndrome, putting them into the context of cellular function, carrier sex, and environmental challenges.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.