IL-12 and IL-23 Pathway Inhibition in Inflammatory Bowel Disease

The authors provide a summary of the biology of the interleukin (IL)-12 family cytokines IL-12 and IL-23, discuss the role of these cytokines in intestinal homeostasis and inflammation, and highlight IL-12- and IL-23-directed drug development for the treatment of Crohn’s disease and ulcerative colitis.