Propofol Inhibits Colon Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Regulating SIRT1, Wnt/β-Catenin and PI3K/AKT/mTOR Signaling Pathways

Scientists used propofol to treat LOVO and SW480 cells and Cell Counting Kit-8 to detect proliferation. Self-renewal capacity, cell invasion and migration, flow cytometry analysis, qPCR and Western blotting were performed to detect the suppression of propofol to colon cancer cells and the underlying mechanism.