Discovery and Multimerization of Cross-Reactive Single-Domain Antibodies Against SARS-Like Viruses to Enhance Potency and Address Emerging SARS-CoV-2 Variants

Through llama immunization campaigns, scientists identified single-domainn antibodies that are cross-reactive against multiple emergent coronaviruses. Importantly, a number of these antibodies showed sub-nanomolar potency towards all SARS-like viruses including emergent CoV-2 variants.